I-Chan Huang, PhD
I-Chan Huang, PhD

I-Chan Huang, PhD

Associate Member, St. Jude Faculty

Departments

Education

PhD – Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland
Postdoctoral Fellow – Center for Health Services and Outcomes Research, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland

Research Interests

  • Patient-reported outcomes in clinical application
  • Psychometric analysis
  • Quality of life and symptoms measurement in childhood cancers
  • Social network/integration research in cancer survivors
  • Financial toxicity in childhood cancer

Current Research

  • NIH/NIAMS U01 Patient-Reported Outcomes Measurement Information System (PROMIS), Pediatric Asthma Study, Principal Investigator 
  • NIH/NCI R21 Symptom Progress and adverse health outcomes in adult childhood cancer survivors, Principal Investigator
  • NIH/NIAMS U19 The Child-Centered Outcomes in Practice and Research (COPR) Center of Excellence, Childhood Cancer Survivorship Study, Principal Investigator
  • NIH/NCI U01 Establishment of a Lifetime Cohort of Adults Surviving Childhood Cancer (SJLIFE), Co-Investigator

Selected Publications

See CV for full list
As a Senior & Corresponding Author

Huang I-C, Bhakta N, Brinkman TM, Klosky JL, Krull KR, Srivastava DK, Hudson MM, Robison LL. Determinants and consequences of financial hardship among adult survivors of childhood cancer: a report from St. Jude Lifetime Cohort Study. J Natl Cancer Inst 2018 (in press).

Huang I-C, Brinkman T, Mullins L, Robison L, Pui C-H, Hudson M, Krull K. Child symptoms, parent behaviors, and family strain in long-term survivors of childhood acute lymphoblastic leukemia. Psychooncology 2018 (in press).   

Huang I-C, Klosky JL, Young CM, Murphy SE, Krull KK, Srivastava D, Hudson MM, Robison LL. Misclassification of self-reported smoking in adult survivors of childhood cancer. Pediatr Blood Cancer 2018 (in press).

Huang I-C, Jones CM, Brinkman TM, Hudson MM, Srivastava DK, Li Y, Robison LL, Krull KR. Development of the functional social network index for adolescent and young adult cancer survivors. Cancer 2018 (in press). PMCID: PMC5935560; DOI: 10.1002/cncr.31278

Jones CM, Baker JN, Keesey RM, Eliason RJ, Lanctot JQ, Clegg JL, Mandrell BN, Ness KK, Krull KR, Srivastava DK, Forrest CB, Hudson MM, Robison LL, Huang I-C*. Importance ratings on patient-reported outcome items for survivorship care: comparison between pediatric cancer survivors, parents, and clinicians. Qual Life Res 2018 (in press). PMID: 29671249; DOI: 10.1007/s11136-018-1854-z

Liu W, Cheung YT, Conklin HM, Jacola LM, Srivastava D, Nolan VG, Zhang H, Gurney JG, Huang I-C, Robison LL, Pui CH, Hudson MM, Krull KR. Evolution of neurocognitive function in long-term survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. J Cancer Surviv 2018 (in press). PMID: 29484542; DOI: 10.1007/s11764-018-0679-7

Howell CR, Thompson LA, Gross HE, Reeve BB, Huang SW, DeWalt DA, Huang I-C*. Consistently suboptimal quality of life parallels consistently poor asthma control in children with asthma. Ann Allergy Asthma Immunol 119(6):562-564, 2017. PMCID: PMC5723545

Ehrhardt MJ, Mulrooney DA, Li C, Baassiri MJ, Bjornard K, Sandlund JT, Brinkman TM, Huang I-C, Srivastava DK, Ness KK, Robison LL, Hudson MM, Krull KR. Neurocognitive, psychosocial, and quality-of-life outcomes in adult survivors of childhood non-Hodgkin lymphoma. Cancer 124(2):417-425, 2018. PMCID: PMC5760296

Jones CM, DeWalt DA, Huang I-C*. Impaired patient-reported outcomes predict poor school functioning and daytime sleepiness: the PROMIS® Pediatric Asthma Study. Acad Pediatr 17(8):850-854, 2017. PMCID: PMC5673502

Huang I-C, Hudson MM, Robison LL, Krull KR. Differential impact of symptom phenotypes and chronic conditions on quality of life in cancer survivors and non-cancer individuals: a population study. Cancer Epidemiol Biomarkers Prev 26(7):1124-1132, 2017. PMCID: PMC5500424

Huang I-C, Lee JL, Ketheeswaran P, Jones CM, Revicki DA, Wu AW. Does personality affect health-related quality of life? A systematic review. PLOS One 12(3):e0173806, 2017. PMCID: PMC5371329

Huang I-C, Brinkman TM, Armstrong GT, Leisenring W, Robison LL, Krull KR. Emotional distress impacts quality of life evaluation: a report from the Childhood Cancer Survivor Study. J Cancer Surviv 11(3):309-319 2017. PMCID: PMC5419851

Hudson MM, Ehrhardt MJ, Bhakta N, Baassiri M, Eissa H, Wassim C, Green DM, Mulrooney DA, Armstrong GT, Brinkman TM, Klosky J, Krull KR, Sabin N, Wilson CL, Huang I-C, Bass JK, Hale K, Kaste SC, Khan R, Srivastava DK, Yasui Y, Joshi VM, Srinivasan S, Stokes D, Hoehn ME, Wilson M, Ness KK, Robison LL. Approach for classification and severity-grading of long-term and late-onset health events among childhood cancer survivors in the St. Jude Lifetime Cohort. Cancer Epidemiol Biomarkers Prev 26(5):666-674, 2017. PMCID: PMC5413397

Li Z, Leite WL, Thompson LA, Gross HE, Shenkman EA, Reeve BB, DeWalt DA, Huang I-C*. Determinants of longitudinal health-related quality-of-life change in children with asthma from low-income families: a report from the PROMIS® Pediatric Asthma Study. Clin Exp Allergy 47(3):383-94, 2017. PMCID: PMC5330944

Kadivar H, Kenzik KM, Dewalt DA, Huang I-C*. The Association of English functional health literacy and the receipt of mammography among Hispanic women compared to non-Hispanic U.S.-born women. PLoS One 11(10):e0164307, 2016. PMCID: PMC5061417

Gandhi PK, Schwartz CE, Reeve BB, DeWalt DA, Gross HE, Huang I-C*. An item-level response shift study on the change of health state with the rating of asthma-specific quality of life: a report from the PROMIS® Pediatric Asthma Study. Qual Life Res 25(6):1349-59, 2016. PMCID: PMC4871765

Li Z, Thompson LA, Gross HE, Shenkman EA, Reeve BB, DeWalt DA, Huang I-C*. Longitudinal associations among asthma control, sleep problems, and health-related quality of life in children with asthma: a report from the PROMIS® Pediatric Asthma Study. Sleep Med 20:41-50, 2016. PMCID: PMC4913028

Howell CR, Thompson LA, Gross HE, Reeve BB, DeWalt DA, Huang I-C*. Responsiveness to change in PROMIS® measures among children with asthma: a report from the PROMIS® Pediatric Asthma Study. Value Health 19(2):192-201, 2016. PMCID: PMC4814775 

Howell CR, Gross HE, Reeve BB, DeWalt DA, Huang I-C*. Known-groups validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) in adolescents and young adults with special healthcare needs. Qual Life Res 25 (7):1815-23, 2016. PMID: 26872912 

Thissen D, Liu Y, Magnus B, Quinn H, Gipson DS, Dampier C, Huang I-C, Hinds PS, Selewski DT, Reeve BB, Gross HE, DeWalt DA. Estimating minimally important difference (MID) in PROMIS pediatric measures using the scale-judgment method. Qual Life Res 25(1):13-23, 2016. PMCID: PMC4695321

Gandhi PK, Revicki DA, Huang I-C*. Adolescent body weight and health-related quality of life rated by adolescents and parents: the issue of measurement bias. BMC Public Health 15:1192, 2015. PMCID: PMC4663736. 

Reeve BB, Thissen D, DeWalt DA, Huang I-C, Liu Y, Magnus B, Quinn H, Gross HE, Kisala PA, Ni P, Haley S, Mulcahey MJ, Charlifue S, A Hanks R, Slavin M, Jette A, Tulsky DS. Linkage between the PROMIS pediatric and adult emotional distress measures. Qual Life Res 25(4):823-833, 2015. PMCID: PMC4814370

DeWalt DA, Gross HE, Gipson DS, Selewski DT, DeWitt EM, Dampier CD, Hinds PS, Huang I-C, Thissen D, Varni JW. PROMIS® pediatric self-report scales distinguish subgroups of children within and across six common pediatric chronic health conditions. Qual Life Res 24(9):2195-2208, 2015. PMCID: PMC4531096

Gandhi PK, Gentry WM, Kibert JL, Lee EY, Jordan W, Bottorff MB, Huang I-C. The relationship between four health-related quality-of-life indicators and use of mammography and Pap test screening in US women. Qual Life Res 24(9):2113-2128, 2015. PMCID: PMC4531104

Kenzik K, Huang I-C, Rizzo JD, Shenkman E, Wingard J. Relationships among symptoms, psychosocial factors, and health-related quality of life in hematopoietic stem cell transplant survivors. Support Care Cancer 23(3):797-807, 2015. PMCID: PMC4312505

Gandhi PK, Thompson LA, Tuli SY, Revicki DA, Shenkman E, Huang I-C*. Developing item banks for measuring pediatric generic health-related quality of life: an application of the International Classification of Functioning, Disability and Health for Children and Youth and item response theory. PLoS One 9(9):e107771, 2014. PMCID: PMC4182329. 

Kenzik KM, Huang I-C, Brinkman TM, Baughman B, Ness KK, Shenkman EA, Hudson MM, Robison LL, Krull KR. The Childhood Cancer Survivor Study-Neurocognitive Questionnaire (CCSS-NCQ) revised: item response analysis and concurrent validity. Neuropsychology 29(1):31-44, 2015. PMCID: PMC4268097.

Kenzik KM, Tuli S, Revicki D, Shenkman EA, Huang I-C*. Comparison of four pediatric health-related quality-of-life instruments: a study on a Medicaid population. Med Decis Making 34(5):590-602, 2014. PMCID: PMC4199940 

Quinn GP, Murphy D, Fortier MA, Sehovic I, Eddleton KZ, Huang I-C. Quality of life tools and young adult survivors of pediatric cancer: a commentary on the need to examine perceptions of romantic relationships. J Adolesc Young Adult Oncol 3(1):47-9, 2014. doi:10.1089/jayao.2013.0020.

Huang I-C. Measuring pediatric patient-reported outcomes: good progress but a long way to go. Qual Life Res 23(3):747-750, 2014. PMCID: PMC4301734

Show More

Varni JW, Magnus B, Stucky BD, Liu Y, Quinn H, Thissen D, Gross HE, Huang I-C, DeWalt DA. Psychometric properties of the PROMIS® Pediatric Scales: precision, stability, and comparison of different scoring and administration options. Qual Life Res 23(4):1233-43, 2014. PMCID: PMC4312615

Gandhi PK, Ried LD, Kimberlin CL, Kauf TL, Huang I-C. Influence of explanatory and confounding variables on HRQoL – does measurement bias and/or response shift affect the results? Expert Rev Pharmacoecon Outcomes Res 13(6):841-51, 2013. PMCID: PMC4308958

Huang I-C, Brinkman TM, Kenzik KM, Gurney JG, Ness KK, Lanctot J, Shenkman EA, Robison LL, Hudson MM, Krull KR. Association between the prevalence of symptoms and health-related quality of life in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort study. J Clin Oncol31(33):4242-51, 2013. PMCID: PMC3821013

Huang I-C, Anderson M, Gandhi P, Tuli S, Krull K, Lai J-S, Nackashi J, Shenkman E. The relationships between fatigue, quality of life, and family impact among children with special health care needs. J Pediatr Psychol 38(7):722-31, 2013. PMCID: PMC3721186

Li Z, Huang I-C*, Thompson LA, Tuli S, Huang S-W, DeWalt D, Revicki D, Shenkman E. The relationships between asthma control, daytime sleepiness, and quality of life among children with asthma: a path analysis. Sleep Med 14(7):641-7, 2013. PMCID: PMC3715592 

Gandhi PK, Kenzik KM, Thompson LA, DeWalt DA, Revicki DA, Shenkman EA, Huang I-C*. Exploring factors influencing asthma control and asthma-specific health-related quality of life among children. Respir Res 14:26, 2013. PMCID: PMC3599064. Note, indicated by the publisher as a “highly access” article.

Gandhi P, Ried LD, Huang I-C, Kimberlin C, Kauf T. Assessment of response shift using two structural equation modeling techniques. Qual Life Res 22(3):461-71, 2013. PMCID: PMC4295627

Quinn GP, Huang I-C, Murphy D, Zidonik-Eddelton K, Krull K. Missing content from health-related quality of life instruments: Interviews with young adult survivors of childhood cancer. Qual Life Res 22(1):111-8, 2013. PMCID: PMC4291119

Huang I-C, Quinn QP, Krull KR, Eddleton KZ, Murphy DC, Shenkman EA, Shearer PD. Head-to-head comparisons of quality of life instruments for young adult survivors of childhood cancer. Support Care Cancer 20(9):2061-71, 2012. PMCID: PMC3320678

Huang I-C, Quinn GP, Wen P-S, Shenkman EA, Revicki DA, Krull K, Li Z, Shearer PD. Using three legacy measures to develop a health-related quality of life tool for young adult survivors of childhood cancer. Qual Life Res 21(8):1437-50, 2012. PMCID: PMC3328688

Pendley CL, Quinn GP, Shenkman EA, Curbow BA, Zebrack BJ, Huang I-C*. Quality of life of young adult survivors of childhood cancer: A review of qualitative studies. J Adolesc Young Adult Oncol 1(3):124-32, 2011. PMCID: PMC3621306. Note, selected as a “feature article” for discussion in the 2013 Annual Conference of the Society for Adolescent and Young Adult Oncology (SAYAO).

Werch CE, Bian H, Carlson J, Moore MJ, DiClemente CC, Huang I-C, Ames SC, Thombs D, Weiler RM, Pokorny SB. Brief integrative multiple behavior intervention effects and mediators for adolescents. J Behav Med 34(1):3-12, 2011. PMID: PMC20661637

Huang I-C, Leite W, Shearer PD, Seid M, Revicki DA, Shenkman EA. Differential item functioning in pediatric quality of life measure between children with and without special health needs. Value Health 14(6):872-83, 2011. PMCID: PMC3173710

Huang I-C, Wen P-S, Revicki DA, Shenkman EA. Quality of life measurement for children with life-threatening conditions: limitations and a new framework. Child Indic Res 4(1):145-160, 2011. PMCID: PMC3133777

Huang I-C, Shenkman EA, Madden VL, Vadaparampiln S, Quinn G, Knapp CA. Measuring quality of life in pediatric palliative care: challenges and potential solutions. Palliat Med 24(2):175-82, 2010. PMCID: PMC3810279

Huang I-C, Thompson LA, Chi Y-Y, Knapp CA, Revicki DA, Seid M, Shenkman EA. The linkage between pediatric quality of life and health conditions: establishing clinically meaningful cutoff scores for the PedsQL. Value Health 12(5):773-81, 2009. PMCID: PMC4299816

Huang I-C, Shenkman EA, Leite W, Knapp CA, Thompson LA, Revicki DA. Agreement was not found in adolescents’ quality of life rated by parents and adolescents. J Clin Epidemiol 62(3):337-46, 2009. PMCID: PMC3812676

Huang I-C, Wu AW, Frangakis C. Do the SF-36 and WHOQOL-BREF measure the same constructs? Qual Life Res 15(1):15-24, 2006. PMID: 16411027

Huang I-C, Frangakis C, Wu AW. The relationship of excess body weight and health-related quality of life: evidence from a population study in Taiwan. Int J Obes (Lond) 30(8):1250-1259, 2006. PMID: 16520814

Huang I-C, Dominici F, Frangakis C, Diette GB, Damberg CL, Wu AW. Is risk-adjustor selection more important than statistical approach for provider profiling? Asthma as an example. Med Decis Making 25(1):20-34, 2005. PMID: 15673579

Huang I-C, Frangakis C, Dominici F, Diette GB, Wu AW. Application of a propensity score approach for risk adjustment in profiling multiple physician groups on asthma care. Health Serv Res 40(1):253-278, 2005. PMCID: PMC1361136

Last update: May 2018