I-Chan Huang, PhD
I-Chan Huang, PhD

I-Chan Huang, PhD

Member, St. Jude Faculty

Departments

Education

PhD – Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland
Postdoctoral Fellow – Center for Health Services and Outcomes Research, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland

Research Interests

  • Patient-reported outcomes measurement and clinical application
  • Psychometric analysis
  • Quality of life and symptoms assessment in childhood cancers
  • Social network/integration research in cancer survivors
  • Financial toxicity in childhood cancer

Current Research

  • NIH/NCI R01 Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events for Survivors of Childhood Cancer (PRO-CTCAE-SCC), Principal Investigator
  • NIH/NCI R21 Symptom Progress and adverse health outcomes in adult childhood cancer survivors, Principal Investigator
  • NIH/NIAMS U19 The Child-Centered Outcomes in Practice and Research (COPR) Center of Excellence, Childhood Cancer Survivorship Study, Principal Investigator
  • NIH/NCI U01 Establishment of a Lifetime Cohort of Adults Surviving Childhood Cancer (SJLIFE), Co-Investigator

Selected Publications

See CV for full list
As a Senior & Corresponding Author

Yen H-J, Eissa HM, Bhatt NS, Huang S, Ehrhardt MJ, Bhakta N, Ness KK, Krull KR, Srivastava DK, Robison LL, Hudson MM, Huang I-C*. Patient-reported outcomes in survivors of childhood hematologic malignancies with hematopoietic stem cell transplant. Blood 2020 (Accepted for publication). PMID: 32243495 DOI: 10.1182/blood.2019003858

Sim J-A, Hyun G, Gibson TM, Yasui Y, Leisenring W, Hudson MM, Robison LL, Armstrong GT, Krull KR, Huang I-C*. Negligible effects of the survey modes for patient-reported outcomes: a report from the Childhood Cancer Survivor Study. JCO Clin Cancer Inform 4:10-24, 2020. PMID: 31951475 PMCID: PMC6995263

Huang I-C, Bhakta N, Brinkman TM, Klosky JL, Krull KR, Srivastava DK, Hudson MM, Robison LL. Determinants and consequences of financial hardship among adult survivors of childhood cancer: a report from St. Jude Lifetime Cohort Study. J Natl Cancer Inst 111(2):189-200, 2019. PMID: 30085213 PMCID: PMC6657283 DOI: 10.1093/jnci/djy120

Li Z, Xu X, Thompson LA, Gross HE, Shenkman EA, Reeve BB, DeWalt DA, Huang I-C*. Longitudinal effect of ambient air pollution and pollen exposure on asthma control: the Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Asthma Study. Acad Pediatr 19(6): 615-623, 2019. PMID: 31128384 DOI: 10.1016/j.acap.2019.03.010

Brinkman TM, Ness KK, Li Z, Huang I-C, Krull KR, Gajjar A, Merchant TE, Klosky J, Partin R, Olsson IT, Boop F, Klimo P, Chemaitilly W, Khan R, Srivastava D, Robison L, Hudson M, Armstrong GT.  Attainment of functional and social independence in adult survivors of pediatric CNS tumors: a report from the St. Jude Lifetime Cohort Study. J Clin Oncol 36(27):2762-2769, 2018. PMID: 30091946 PMCID: PMC6145833 DOI: 10.1200/JCO.2018.77.9454

Huang I-C, Brinkman T, Mullins L, Robison L, Pui C-H, Hudson M, Krull K. Child symptoms, parent behaviors, and family strain in long-term survivors of childhood acute lymphoblastic leukemia. Psychooncology 27(8):2031-2038, 2018. PMID: 29772082 PMCID: PMC6298222 DOI: 10.1002/pon.4769

Huang I-C, Klosky JL, Young CM, Murphy SE, Krull KK, Srivastava D, Hudson MM, Robison LL. Misclassification of self-reported smoking in adult survivors of childhood cancer. Pediatr Blood Cancer 65(9):e27240, 2018. PMID: 29856513 PMCID: PMC6105425 DOI: 10.1002/pbc.27240

Huang I-C, Jones CM, Brinkman TM, Hudson MM, Srivastava DK, Li Y, Robison LL, Krull KR. Development of the functional social network index for adolescent and young adult cancer survivors. Cancer 15;124(10):2220-2227, 2018. PMCID: PMC5935560; DOI: 10.1002/cncr.31278

Jones CM, Baker JN, Keesey RM, Eliason RJ, Lanctot JQ, Clegg JL, Mandrell BN, Ness KK, Krull KR, Srivastava DK, Forrest CB, Hudson MM, Robison LL, Huang I-C*. Importance ratings on patient-reported outcome items for survivorship care: comparison between pediatric cancer survivors, parents, and clinicians. Qual Life Res 27(7):1877-1884, 2018. PMID: 29671249; DOI: 10.1007/s11136-018-1854-z

Liu W, Cheung YT, Conklin HM, Jacola LM, Srivastava D, Nolan VG, Zhang H, Gurney JG, Huang I-C, Robison LL, Pui CH, Hudson MM, Krull KR. Evolution of neurocognitive function in long-term survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. J Cancer Surviv 12(3):398-406, 2018. PMID: 29484542; DOI: 10.1007/s11764-018-0679-7

Ehrhardt MJ, Mulrooney DA, Li C, Baassiri MJ, Bjornard K, Sandlund JT, Brinkman TM, Huang I-C, Srivastava DK, Ness KK, Robison LL, Hudson MM, Krull KR. Neurocognitive, psychosocial, and quality-of-life outcomes in adult survivors of childhood non-Hodgkin lymphoma. Cancer 124(2):417-425, 2018. PMCID: PMC5760296

Howell CR, Thompson LA, Gross HE, Reeve BB, Huang SW, DeWalt DA, Huang I-C*. Consistently suboptimal quality of life parallels consistently poor asthma control in children with asthma. Ann Allergy Asthma Immunol 119(6):562-564, 2017. PMCID: PMC5723545

Jones CM, DeWalt DA, Huang I-C*. Impaired patient-reported outcomes predict poor school functioning and daytime sleepiness: the PROMIS® Pediatric Asthma Study. Acad Pediatr 17(8):850-854, 2017. PMCID: PMC5673502

Huang I-C, Hudson MM, Robison LL, Krull KR. Differential impact of symptom phenotypes and chronic conditions on quality of life in cancer survivors and non-cancer individuals: a population study. Cancer Epidemiol Biomarkers Prev 26(7):1124-1132, 2017. PMCID: PMC5500424

Huang I-C, Lee JL, Ketheeswaran P, Jones CM, Revicki DA, Wu AW. Does personality affect health-related quality of life? A systematic review. PLOS One 12(3):e0173806, 2017. PMCID: PMC5371329

Huang I-C, Brinkman TM, Armstrong GT, Leisenring W, Robison LL, Krull KR. Emotional distress impacts quality of life evaluation: a report from the Childhood Cancer Survivor Study. J Cancer Surviv 11(3):309-319, 2017. PMCID: PMC5419851

Hudson MM, Ehrhardt MJ, Bhakta N, Baassiri M, Eissa H, Wassim C, Green DM, Mulrooney DA, Armstrong GT, Brinkman TM, Klosky J, Krull KR, Sabin N, Wilson CL, Huang I-C, Bass JK, Hale K, Kaste SC, Khan R, Srivastava DK, Yasui Y, Joshi VM, Srinivasan S, Stokes D, Hoehn ME, Wilson M, Ness KK, Robison LL. Approach for classification and severity-grading of long-term and late-onset health events among childhood cancer survivors in the St. Jude Lifetime Cohort. Cancer Epidemiol Biomarkers Prev 26(5):666-674, 2017. PMCID: PMC5413397

Li Z, Leite WL, Thompson LA, Gross HE, Shenkman EA, Reeve BB, DeWalt DA, Huang I-C*. Determinants of longitudinal health-related quality-of-life change in children with asthma from low-income families: a report from the PROMIS® Pediatric Asthma Study. Clin Exp Allergy 47(3):383-94, 2017. PMCID: PMC5330944

Kadivar H, Kenzik KM, Dewalt DA, Huang I-C*. The Association of English functional health literacy and the receipt of mammography among Hispanic women compared to non-Hispanic U.S.-born women. PLoS One 11(10):e0164307, 2016. PMCID: PMC5061417

Gandhi PK, Schwartz CE, Reeve BB, DeWalt DA, Gross HE, Huang I-C*. An item-level response shift study on the change of health state with the rating of asthma-specific quality of life: a report from the PROMIS® Pediatric Asthma Study. Qual Life Res 25(6):1349-59, 2016. PMCID: PMC4871765

Li Z, Thompson LA, Gross HE, Shenkman EA, Reeve BB, DeWalt DA, Huang I-C*. Longitudinal associations among asthma control, sleep problems, and health-related quality of life in children with asthma: a report from the PROMIS® Pediatric Asthma Study. Sleep Med 20:41-50, 2016. PMCID: PMC4913028

Howell CR, Thompson LA, Gross HE, Reeve BB, DeWalt DA, Huang I-C*. Responsiveness to change in PROMIS® measures among children with asthma: a report from the PROMIS® Pediatric Asthma Study. Value Health 19(2):192-201, 2016. PMCID: PMC4814775

Howell CR, Gross HE, Reeve BB, DeWalt DA, Huang I-C*. Known-groups validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) in adolescents and young adults with special healthcare needs. Qual Life Res 25 (7):1815-23, 2016. PMID: 26872912

Thissen D, Liu Y, Magnus B, Quinn H, Gipson DS, Dampier C, Huang I-C, Hinds PS, Selewski DT, Reeve BB, Gross HE, DeWalt DA. Estimating minimally important difference (MID) in PROMIS pediatric measures using the scale-judgment method. Qual Life Res 25(1):13-23, 2016. PMCID: PMC4695321

Gandhi PK, Revicki DA, Huang I-C*. Adolescent body weight and health-related quality of life rated by adolescents and parents: the issue of measurement bias. BMC Public Health 15:1192, 2015. PMCID: PMC4663736.

Reeve BB, Thissen D, DeWalt DA, Huang I-C, Liu Y, Magnus B, Quinn H, Gross HE, Kisala PA, Ni P, Haley S, Mulcahey MJ, Charlifue S, A Hanks R, Slavin M, Jette A, Tulsky DS. Linkage between the PROMIS pediatric and adult emotional distress measures. Qual Life Res 25(4):823-833, 2015. PMCID: PMC4814370

DeWalt DA, Gross HE, Gipson DS, Selewski DT, DeWitt EM, Dampier CD, Hinds PS, Huang I-C, Thissen D, Varni JW. PROMIS® pediatric self-report scales distinguish subgroups of children within and across six common pediatric chronic health conditions. Qual Life Res 24(9):2195-2208, 2015. PMCID: PMC4531096

Kenzik K, Huang I-C, Rizzo JD, Shenkman E, Wingard J. Relationships among symptoms, psychosocial factors, and health-related quality of life in hematopoietic stem cell transplant survivors. Support Care Cancer 23(3):797-807, 2015. PMCID: PMC4312505

Kenzik KM, Huang I-C, Brinkman TM, Baughman B, Ness KK, Shenkman EA, Hudson MM, Robison LL, Krull KR. The Childhood Cancer Survivor Study-Neurocognitive Questionnaire (CCSS-NCQ) revised: item response analysis and concurrent validity. Neuropsychology 29(1):31-44, 2015. PMCID: PMC4268097.

Gandhi PK, Thompson LA, Tuli SY, Revicki DA, Shenkman E, Huang I-C*. Developing item banks for measuring pediatric generic health-related quality of life: an application of the International Classification of Functioning, Disability and Health for Children and Youth and item response theory. PLoS One 9(9):e107771, 2014. PMCID: PMC4182329.

Kenzik KM, Tuli S, Revicki D, Shenkman EA, Huang I-C*. Comparison of four pediatric health-related quality-of-life instruments: a study on a Medicaid population. Med Decis Making 34(5):590-602, 2014. PMCID: PMC4199940

Quinn GP, Murphy D, Fortier MA, Sehovic I, Eddleton KZ, Huang I-C. Quality of life tools and young adult survivors of pediatric cancer: a commentary on the need to examine perceptions of romantic relationships. J Adolesc Young Adult Oncol 3(1):47-9, 2014. doi:10.1089/jayao.2013.0020.

Huang I-C. Measuring pediatric patient-reported outcomes: good progress but a long way to go. Qual Life Res 23(3):747-750, 2014. PMCID: PMC4301734

Show More

Varni JW, Magnus B, Stucky BD, Liu Y, Quinn H, Thissen D, Gross HE, Huang I-C, DeWalt DA. Psychometric properties of the PROMIS® pediatric scales: precision, stability, and comparison of different scoring and administration options. Qual Life Res 23(4):1233-1243, 2014. PMID: 24085345

Huang I-C, Brinkman TM, Kenzik K, Gurney JG, Ness KK, Lanctot J, Shenkman E, Robison LL, Hudson MM, Krull KR. Association between the prevalence of symptoms and health-related quality of life in adult survivors of childhood cancer: a report from the St. Jude Lifetime Cohort study. J Clin Oncol 20;31(33):4242-4251, 2013. PMCID: 24127449

Gandhi PK, Kenzik KM, Thompson LA, DeWalt DA, Revicki DA, Shenkman EA, Huang I-C*. Exploring factors influencing asthma control and asthma-specific health-related quality of life among children. Respir Res 23;14:26, 2013. PMID: 23432913.

Li Z, Huang I-C*, Thompson L, Tuli S, Huang SW, DeWalt D, Revicki D, Shenkman E. The relationships between asthma control, daytime sleepiness, and quality of life among children with asthma: a path analysis. Sleep Med 14(7):641-647, 2013. PMCID: 23684939

Huang I-C, Anderson M, Gandhi P, Tuli S, Krull K, Lai JS, Nackashi J, Shenkman E. The relationships between fatigue, quality of life, and family impact among children with special health care needs. J Pediatr Psychol 38(7):722-731, 2013. PMCID: 23584707

Huang I-C, Quinn GP, Wen PS, Shenkman EA, Revicki DA, Krull K, Li Z, Shearer PD. Using three legacy measures to develop a health-related quality of life tool for young adult survivors of childhood cancer. Qual Life Res 21(8):1437-1450, 2012. PMID: 22101901

Huang I-C, Quinn GP, Krull K, Eddleton KZ, Murphy DC, Shenkman EA, Shearer PD. Head-to-head comparisons of quality of life instruments for young adult survivors of childhood cancer. Support Care Cancer 20(9):2061-2071, 2012. PMID: 22105163

Nightingale CL, Quinn GP, Shenkman EA, Curbow BA, Zebrack BJ, Krull KR, Huang I-C*. Health-related quality of life of young adult survivors of childhood cancer: a review of qualitative studies. J Adolesc Young Adult Oncol 1(3):124-132, 2011. PMID: 23610733

Huang I-C, Leite WL, Shearer P, Seid M, Revicki DA, Shenkman EA. Differential item functioning in quality of life measure between children with and without special health-care needs. Value Health 14(6):872-883, 2011. PMID: 21914509

Wingard JR, Huang I-C, Sobocinski KA, Andrykowski MA, Cella D, Rizzo JD, Brady M, Horowitz MM, Bishop MM. Factors associated with self-reported physical and mental health after hematopoietic cell transplantation. Biol Blood Marrow Transplant 16(12):1682-1692, 2010. PMID: 20685400

Huang I-C, Shenkman EA, Madden VL, Vadaparampil S, Quinn G, Knapp CA. Measuring quality of life in pediatric palliative care: challenges and potential solutions. Palliat Med 24(2):175-182, 2010. PMID: 20007819

Huang I-C, Shenkman EA, Leite W, Knapp CA, Thompson LA, Revicki DA. Agreement was not found in adolescents’ quality of life rated by parents and adolescents. J Clin Epidemiol 62(3):337-346, 2009. PMID: 18834712

Huang I-C, Thompson LA, Chi YY, Knapp CA, Revicki DA, Seid M, Shenkman EA. The linkage between pediatric quality of life and health conditions: establishing clinically meaningful cutoff scores for the PedsQL. Value Health 12(5):773-781, 20089. PMID: 19508660

Huang I-C, Willke RJ, Atkinson MJ, Lenderking WR, Frangakis C, Wu AW. US and UK versions of the EQ-5D preference weights: does choice of preference weights make a difference? Qual Life Res 16(6):1065-1072, 2007. PMID: 17415683

Huang I-C, Frangakis C, Dominici F, Diette GB, Wu AW. Application of a propensity score approach for risk adjustment in profiling multiple physician groups on asthma care. Health Serv Res 40(1):253-278, 2005. PMID: 15663712

Huang I-C, Dominici F, Frangakis C, Diette GB, Damberg CL, Wu AW. Is risk-adjustor selection more important than statistical approach for provider profiling? Asthma as an example. Med Decis Making 25(1):20-34, 2005. PMID: 15673579

Last update: April 2020

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