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Lisa Jacola, PhD, ABPP-CN
Lisa Jacola, PhD, ABPP-CN

Lisa Jacola, PhD, ABPP-CN

Assistant Member, St. Jude Faculty

  • Pediatric Neuropsychologist
  • Board Certified in Clinical Neuropsychology

Departments

Education

Fellowship – St. Jude Children’s Research Hospital
Internship – The University of Chicago
PhD – University of Cincinnati
MS – Wright State University
BA – University of Dayton

Research Interests

  • Neurobehavioral outcomes in children treated for acute lymphoblastic leukemia (ALL) and brain tumors
    • Identification of neural mechanisms related to neurodevelopmental changes following treatment
    • Development and implementation of interventions designed to improve neurobehavioral outcomes following cancer treatment
  • Measurement of neuropsychological functions in children with acquired neurologic injury and neurodevelopmental disability
    • Improving specification of brain-behavior relationships
    • Quantifying the relationship between neurocognitive ability and functional outcomes across the lifespan

Selected Publications

Harman JL, Molnar AE, Jacola LM, Corr A, Scott A, Potter B, Schwartzberg, Boyer H, Greear J, Willard VW. Establishment of a hospital-based early intervention program for young children with cancer: a quality improvement initiative. Clin Prac Ped Psych Nov 30, 2020. Advance online publication. http://dx.doi.org/10.1037/cpp0000375

Partanen M, Phipps S, Russell K, Anghelescu DA, Wolf J, Conklin HM, Krull KR, Inaba H, Pui CH, Jacola LM. Longitudinal trajectories of neurocognitive functioning in childhood acute lymphoblastic leukemia. J Pediatr Psychol Oct 4, 2020. doi:10.1093/jpepsy/jsaa086. Online ahead of print. PMID:33011782.

Bjornard KL, Howell CR, Klosky JL, Chemaitilly W, Srivastava DK, Brinkman TM, Green DM, Willard VW, Jacola LM, Krasin MJ, Hudson MM, Robison LL and Ness KK.  Psychosexual functioning of female childhood cancer survivors:  a report from the St. Jude Lifetime Cohort Study. J Sex Med Jul 25:S1743-6095(20)30679-2, 2020. doi: 10.1016/j.jsxm.2020.06.005. Epub ahead of print. PMID:32723681.

Pryweller JR, Glass JO, Sabin ND, Laningham FH, Li Y, Jacola LM, Conklin HM, Reddick WE. Characterization of leukoencephalopathy and association with later neurocognitive performance in pediatric acute lymphoblastic leukemia. Invest Radiol Aug 6, 2020. doi:10.1097/RLI.0000000000000715. online ahead of print. PMID:32769417.

van der Plas E, Qiu W, Neiman BJ, Yasui Y, Liu Q, Dixon S, Kadan-Lottick N, Jacola LM, Gibson T, Leisenring W, Oeffinger K, Hudson Melissa M., Robinson LL, Armstrong GT, Krull KR. Sex dependent associations between chemotherapy, chronic conditions and neurocognitive impairment in pediatric ALL survivors: A report from the Childhood Cancer Survivor Study. J Nat Cancer Inst (Published online ahead of print, Sep 3, 2020) doi:10.1093/jnci/djaa136. PMID: 32882041.

Jacola LM, Anghelescu DL, Hall L, Russell K, Zhang H, Wang F, Peters JB, Rossi M, Schreiber JE, Gajjar A. Anesthesia exposure and neurocognitive outcomes in survivors of childhood medulloblastoma treated with risk-adapted protocol therapy. J Pediatr Aug; 223:141-147, 2020. doi:10.1016/j.jpeds.2020.04.039. Epub 2020 Jun 9. PMID:32532646.

Gandy KC, Castillo HA, Ouellette L, Castillo J, Lupo PJ, Jacola LM, Rabin KR, Raghubar KP, Gramatges MM. The relationship between chronic health conditions and cognitive deficits in children, adolescents, and young adults with down syndrome: A systematic review. PLoS One Sep 11;15(9):e0239040, 2020. doi: 10.1371/journal.pone.0239040. eCollection 2020. PMID: 32915911.

Partanen M, Kang G, Wang W, Krull K, King AA, Schreiber JE, Porter JS, Hodges J, Hankins JS, Jacola LM.  Association between hydroxycarbamide exposure and neurocognitive function in adolescents with sickle cell disease. Br J Haematol Jun;189(6):1192-1203, 2020. doi: 10.1111/bjh.16519. Epub 2020 Feb 26, 2020

Banerjee P, Rossi MG, Anghelescu DL, Liu W, Breazeale AM, Reddick WE, Glass JO, Phillips NS, Jacola LM, Sabin ND, Inaba H, Srivastava D, Robison LL, Pui CH, Hudson MM, Krull KR. Anesthesia impact on neurocognitive and neuroimaging outcomes in long-term survivors of childhood acute lymphoblastic leukemia. JAMA Oncol Jun 20, 2019. PMID: 31219514. doi: 10.1001/jamaoncol.2019.1094

Al-Fahad R, Yeasin M, Glass JO, Conklin HM, Jacola LM, Reddick WE. Early Imaging-Based Predictive Modeling of Cognitive Performance Following Therapy for Childhood ALL. IEEE Access (7)146662-146674, 2019. DOI:10.1109/ACCESS.2019.2946240

Esbensen AJ, Hoffman EK, Shaffer R, Chen E, Patel L, Jacola LM. Reliability of parent report measures of executive functioning in children with Down syndrome, Am J Intellect Dev Disabil May; 124(3), 220-233, 2019. PMID: 31026204. PMCID: PMC6487878. doi: 10.1352/1944-7558-124.3.220.

Liu APY, Harreld JH, Jacola LM, Gero M, Acharya S, Ghazwani Y, Wu S, Li X, Klimo P Jr, Gajjar A, Chiang J, Qaddoumi I. Tectal glioma as a distinct diagnostic entity: a comprehensive clinical, imaging, histologic and molecular analysis. Acta Neuropathol Commun Sep 25;6(1):101, 2018. PMID: 30253793. PMCID: PMC6154813. doi: 10.1186/s40478-018-0602-5.

Esbensen AJ, Hoffman EK, Shaffer R, Chen E, Patel L, Jacola LM. Reliability of parent report measures of behavior in children with Down syndrome, J Intellect Disabil Res 2018 Sep; 62(9):785-797. Sept 2018. PMID: 30022564. PMCID: PMC6074042. doi: 10.1111/jir.12533. Epub Jul 18,  2018.

Jensen CD, Jacola LM, Schatz J. Introduction to the special issue on neural processes and pediatric health: creating a pediatric health neuroscience research agenda. J Pediatr Psychol Sept 1; 43(8):815-820, 2018. PMID: 30007324. doi: 10.1093/jpepsy/jsy045.

Liu W, Cheung YT, Conklin H, Jacola LM, Srivastava DK, Nolan V, Zhang H, Gurney J, Huang I, Robison L, Pui C-H, Hudson M, Krull, K. Evolution of neurocognitive function in long-term survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. J Cancer Surviv Jun; 12(3): 398-406, 2018. PMID: 29484542. PMCID: PMC5955829. doi: 10.1007/s11764-018-0679-7. Epub 2018 Feb 27.

Walker B, Conklin HC, Anghelescu D, Hall LP, Reddick WE, Ogg RJ, Jacola LM. Parent perspectives and preferences for strategies regarding nonsedated MRI scans in a pediatric oncology population. Support Care Cancer Jun; 26(6): 1815-1824, 2018. PMID: 29260390. PMCID: PMC5940333. doi: 10.1007/s00520-017-4009-9. Epub 2017 Dec 19.

Jacola LM, Edelstein K, Liu W, Pui CH, Hayashi H, Kadan-Lottick N, et al. Cognitive, behavior, and academic functioning in adolescent and young adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Lancet Psychiatry Oct; 3(10):965-972, 2016. PMID: 27639661. PMCID: PMC5056029. doi: 10.1016/S2215- 0366(16)30283-8. Epub 2016 Sep 14.

Jacola LM, Krull KR, Pui C-H, Pei D, Cheng C, Reddick WE, Conklin HM. Reply to S. Kaur et al. J Clin Oncol Oct 20; 34(30):3708-3709, 2016. PMID:  27551120. doi: 10.1200/JCO.2016.68.7780.

Jacola LM. Neuropsychological assessment of adolescents and emerging young adults with childhood epilepsy. J Pediatr Epilepsy 6:69-74, 2017. doi: 10.1055/s-0036-1585060.

Jacola LM, Conklin HC, Scoggins M, Ashford JA, Merchant TE, Mandrell BN, Ogg RJ, Curtis E, Wise MS, Indelicato DJ, Crabtree VM. Investigating the role of hypothalamic tumor involvement in sleep and neurocognitive outcomes among children treated for craniopharyngioma. J Pediatr Psychol Jul; 41(6):610-22, 2016. PMID: 27189690. PMCID: PMC4913761. doi: 10.1093/jpepsy/jsw026. Epub May 16, 2016.

Jacola LM, Krull KR, Pui C-H, Pei D, Cheng C, Reddick WE, et al. Longitudinal assessment of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia treated on a contemporary chemotherapy protocol. J Clin Oncol Apr 10; 34(11):1239-47, 2016. PMID: 26858334. PMCID: PMC4872325. doi: 10.1200/JCO.2015.64.3205. Epub Feb 8, 2016.

Jacola LM, Willard VW, Ashford JM, Ogg RJ, Scoggins MA, Jones MM, Wu S, Conklin HM. Clinical utility of the N- back task in functional neuroimaging studies of working memory. J Clin Exp Neuropsychol 36(8):875-86, 2014. PMID: 25252868. PMCID: PMC4229404. doi: 10.1080/13803395.2014.953039. Epub Sep 25, 2014.

Jacola LM, Ashford JM, Reddick WE, Glass JO, Ogg RJ, Merchant TM, Conklin HM. The relationship between working memory abilities and white matter integrity in childhood brain tumor survivors treated with conformal radiation therapy. J Neurooncol Aug; 119(1):197-205, 2014. PMID: 24847967. PMCID: PMC4133306. doi: 10.1007/s11060-014-1476-4. Epub Feb 8,  2016.

Jacola LM, Hickey F, Howe SR, Esbensen A, Shear PK. Behavior problems and adaptive functioning deficits in adolescents with Down syndrome: identifying targets for intervention. J Ment Health Res Intellect Disabil 7(4) 287-305, 2014. PMID: 28539987. PMCID: PMC5440084. doi: 10.1080/19315864.2014.920941. Epub Oct 3, 2014.

Jacola LM, Byars AW, Hickey F, Vannest J, Holland SK, Schapiro MB. Functional magnetic resonance imaging of story listening in adolescents and young adults with Down syndrome: evidence for atypical neurodevelopment. J Intellect Disabil Res Oct;58(10): 892-902, 2014. PMID:  23962356. doi: 10.1111/jir.12089. E pub Aug 20, 2013.

Szaflarski JP, Rajagopal A, Altaye M, Byars AW, Jacola LM, Schmithorst VJ, Schapiro MB, Plante E, Holland SK. Left- handedness and language lateralization in children. Brain Res Jan 18;18:85-97, 2012. PMID: 22177775. PMCID: PMC3249496. doi: 10.1016/j.brainres.2011.11.026. Epub Nov 28, 2011.

Jacola LM, Byars AW, Chalfonte-Evans M, Schmithorst VJ, Hickey F, Patterson B, Hotze S, Holland SK, Vannest, J, Schapiro MB. Functional magnetic resonance imaging of cognitive processing in young adults with Down syndrome. Am J Intellect Dev Disabil. Sep;116(5):344-359, 2011. PMID: 21905803. doi: 10.1352/1944-7558-116.5.344.

Tillema JM, Jacola LM, Schapiro MB, Byars AW, Plante E, Szaflarski JP, Holland SK. Reprint of “Cortical reorganization of language functioning following perinatal left MCA stroke Brain Lang Sep;106(3):184-94, 2008.  PMID: 18762059. doi: 10.1016/j.bandl.2008.08.001.

Szaflarski JP, Holland SK, Jacola LM, Privitera MD, Szaflarski M. Comprehensive presurgical fMRI language evaluation in adult patients with epilepsy. Epilepsy Behav. Jan;12(1):74-83, 2008. PMID: 2763527. PMCID: PMC2763527. doi: 10.1016/j.yebeh.2007.07.015. Epub Oct 25, 2007.

Tillema JM, Jacola LM, Schapiro MB, Byars AW, Plante E, Szaflarski JP, Holland SK. Cortical reorganization of language functioning following left MCA stroke. Brain Lang May;105(2):99-111, 2008. PMID: 17905426.  PMCID: PMC2763390. doi: 10.1016/j.bandl.2007.07.127. Epub Oct 1, 2007.

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Holland SK, Vannest J, Mecoli M, Jacola LM, Tillema JM, Karunanayaka PR, Schmithorst VJ, Yuan WH, Plante E, Byars AW. Functional MRI of language lateralization during development in children. Int J Audiol Sep; 46(9):533-51, 2007. PMID: 17828669.  PMCID: PMC2763431. doi: 10.1080/14992020701448994.

Jacola LM, Schapiro MB, Schmithorst VJ, Byars AW, Strawsburg RH, Szaflarski JP, Holland SK. Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke. Neuropediatrics Feb;37(1):46-52, 2006. PMID: 16541368. PMCID: PMC1859843. doi:   10.1055/s-2006-923934.

Last update: December 2020