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Sue C. Kaste, DO
Sue C. Kaste, DO

Sue C. Kaste, DO

Emeritus, St. Jude Faculty



DO – Chicago College of Osteopathic Medicine, Illinois

Research Interests

  • Pediatric oncologic imaging
    • Oncologic orthopedic imaging
    • Oncologic dental imaging
    • Oncologic orbital imaging
  • Diagnostic imaging of "late effects" of oncotherapy
  • Skeletal sequelae in childhood cancer survivors (bone mineral density; osteonecrosis)
  • Control of radiation exposure in pediatric medical imaging

Selected Publications

Tinkle CL, Fernandez-Pineda I, Sykes A, Lu Z, Hua C, Neel MD, Bahrami A, Shulkin BL, Kaste SC, Pappo A, Spunt SL, Krasin MJ. Non-Rhabdomyosarcoma soft tissue sarcoma (NRSTS) in pediatric and young adult patients: results from a prospective study using limited margin radiotherapy. Cancer April 2017 (in press).

Lucas JT,Fernandez-Pineda I, Tinkle CL, Bishop MW, Kaste SC, Heda, R, Davidoff AM, Krasin MJ. Late Toxicity and Outcomes Following Radiation Therapy for Pediatric Chest Wall Sarcomas. Practical Rad Onc April 2017 (in press).

Chemaitilly W, Li Z, Krasin MJ, Brooke RJ, Wilson CL, Green DM, Klosky JL, Barnes N, Clark KL, Farr JB, Fernandez-Pineda I, Bishop MW, Metzger M, Pui C-H, Kaste SC, Ness KK, Srivastava DK, Robison LL, Hudson MM, Yasui Y, Sklar CA. Premature Ovarian Insufficiency in Childhood Cancer Survivors: A Report from the St. Jude Lifetime Cohort. J Clin Endo Metab March 2017 (in press).

Flerlage J, Kelly K, Kluge R, Hoppe B, Kurch L, Beishuizen A, Kaste SC, Punnett A, Voss S, McCarten K, Dieckmann U, Howard S, DeAlarcon PA, Lewis J, Dachtman RA, Link MP, Landman-Parker  J, Wallace H,  Mauz-Ktirholz C, Metzger ML. Staging Evaluation and Response Criteria Harmonization (SEARCH) for Childhood, Adolescent and Young Adult Hodgkin Lymphoma (CAYAHL).  Pediatr Blood Cancer  00:e26421, 2017. doi  10.1002/pbc.26421

Hudson MM, Ehrhardt MJ, Bhakta N, Baassiri M, Elssa H, Chenaitilly W, Green DM, Mulrooney DA, Armstrong GT, Brinkman TM, Klosky JL, Krull KR, Sabin ND, Wilson CL, Huang I, Bass J, Hale K, Kaste S, Khan R, Srivastava DK, Yasui Y, Josh VM, Stokes D, Hoehn ME, Wilson M, Ness KK, Robinson LL.  Approach for Classification and Severity-grading of Long-Term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort. Cancer Epidemiology, Biomarkers & Prevention Dec 29, 2016. pii:cebp.0812.2016. doi:  10.1158/1055-9965. EPI-16-0812. [Epub ahead of print] PMID: 28035022

Kaste SC, DeFeo BM, Neel MD, Weiss KS, Fernandez-Pineda I, Ness KK. Osteonecrosis of the Shoulders in Pediatric Patients Treated for Leukemia or Lymphoma: Single-Institutional Experience. J Paediatr Orthop November 2016  (in press)

*Portera MV, Karol SE, Kaste SC. Osteonecrosis is unrelated to hip anatomy in children with acute lymphoblastic leukemia. Pediatr Blood Cancer 2016 Dec 30 . doi: 10.1002/pbc.26407.[Epub ahead of print] PMID: 28035753

Ehrhardt M, Sandlund J, Zhang N, Liu W, Ness K, Bhakta N, Chemaitilly W, Krull K, Brinkman T, Crom D, Kun L, Kaste S, Armstrong G, Green D, Srivastava K, Robison L, Hudson M, Mulrooney D. Late Outcomes Of Adult Survivors of Childhood Non-Hodgkin Lymphoma:  A Report from the St. Jude Lifetime Cohort Study. Pediatr Blood Cancer November 15, 2016 doi:10.1002/pbc.26338. PMID:  27860222  [Epub ahead of print]

*Haynes LP, Kaste SC, Ness KK, Wu J, Ortega-Laureano L, Bishop MW, Neel MD, Rao BN, Fernandez-Pineda I. Pathologic Fracture in Childhood and Adolescent Osteosarcoma: A Single Institution Experience. Pediatr Blood Cancer Apr; 64(4), 2016. November 5. doi 10.1002/pbc.26290. Epub 2016 Nov 5. PMID:  27897381

Kaste SC, Snyder S, Metzger ML, Sandlund JT, Howard SC, Krasin M, Shulkin BL. Comparison of 11C-methionine and 18F-FDG PET-CT for staging and follow up of pediatric lymphoma. J Nucl Med Mar; 58(3):419-424, 2017. pii: jnumed: 116.178640. Epub Sep 8. PMID  27809791

Allen B, Migliorati C, Rowland C, An Q, Shintaku W, Donaldson M, Wells M, Kaste S.  Comparison of mandibular cortical thickness and QCT-derived bone mineral density (BMD) in survivors of childhood acute lymphoblastic leukemia:  a retrospective study.  Int J Paediatr Dent Sep;26(5):330-5, 2016. doi:  101111/ipd.12203   PMID:  26370921

Shelmerdine SC, Chavhan GB, Babyn PS, Nathan PC, Kaste SC. lmaging of Late Complications Cancer  Therapy in Children. Pediatr Radiol Pediatr Radiol Mar; 47(3):254-266, 2017. doi: 10.1007/200247-016-3708-6. Epub 2016 Dec 1. PMID:  27904916

Mogil RJ, Kaste SC, Ferry RJ Jr, Hudson MM, Mulrooney DA, Howell CR, Partin RE, Srivastava DK, Robison LL, Ness KK.  Effect of Low-Magnitude, High-Frequency Mechanical Stimulation on BMD Among Young Childhood Cancer Survivors: A Randomized Clinical Trial. JAMA Oncol July;1:2(7):908-14, 2016. doi: 10.1001/jamaoncol.2015.6557. PMID: 26967465

Wilson CL, Chemaitilly W, Jones KE, Kaste SC, Srivastava DK, Ojha RP, Yasui Y, Pui CH, Robison LL, Hudson MM, Ness KK,. Modifiable Factors Associated With Aging Phenotypes Among Adult Survivors of Childhood Acute Lymphoblastic Leukemia. J Clin Oncol July 20;34(21):2509-15, 2016. doi.10.1200/ JCO.2015.64.9525. Epub 2016 Mar 21. PMID: 27001572 PMCID:PMC 4962734

Boland AM, Gibson TM, Lu L, Kaste SC, DeLany JP, Partin RE, Lanctot JQ, Howell CR, Nelson HH, Chemaitilly W, Pui CH, Robison LL, Mulrooney DA, Hudson MM, Ness KK. Dietary Protein Intake and Lean Muscle Mass in Survivors of Childhood Acute Lymphoblastic Leukemia: Report From the St. Jude Lifetime Cohort Study. Phys Ther Jul;96(7):1029-38, 2016. doi: 10.2522/ptj.20150507.  Epub 2016 Feb18. PMID: 26893509

Park H-W, Tse S, Yang W, Kelly HW, Kaste SC, Pui C-H, Relling MV, Tantisira KG. A genetic factor associated with low final bone mineral density in children after a long-term glucocorticoids treatment. Pharmacogenomics J Mar;17(2):180-185, 2017.  doi: 10.1038/tpj.2015.92. 2016 Feb 9. PMID: 26856247

Karol SE, Yang W, Van Driest SL, Chang TY, Kaste S, Bowton E, Basford M, Bastarache L, Roden DM, Denny JC, Larsen E, Winick N, Carroll WL, Cheng C, Pei D, Fernandez CA, Liu C, Smith C, Loh ML, Raetz EA, Hunger SP, Scheet P, Jeha S, Pui CH, Evans WE, Devidas M, Mattano LA Jr, Relling MV. Genetics of glucococorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia. Blood Oct 8;126 (15); 1770-6, 2015. doi: 10.1182/ Blood-2015-05-643601. Epub 2015 Aug 11. PMID: 26265699

Chavhan GB, Babyn PS, Nathan P, Khanna G, Kaste S. Imaging of acute and subacute toxicities of cancer therapy in children. Pediatr Radiol Jan; 46(1):9-20, 2016. doi: 10.1007/s00247-015-3454-1. Epub 2015 Oct 12.  PMID: 26459011

Federico SM, Brady SL, Pappo A, Kaufman R, Kaste S. Reply to: Radiation dose reduction thanks to split-bolus multi-1 detector computer tomography (MDCT) in children with non-thoracic neuroblastoma. Pediatr Blood Cancer Oct;62(10):1867, 2015. doi: 10.1002/pbc.25598. Epub 2015 Jun 1. PMID:26033930

Bishop MW, Somerville JM, Bahrami A, Kaste SC, Interiano R, Wu J, Mao S, Boop FA, Williams R, Pappo A, Samant S. Mesenchymal Chondrosarcoma in Children and Young Adults: A single institution retrospective review. Sarcoma 2015:608279, 2015. doi:10.1155/2015/608279. Epub 2015 Jun. PMID: 26146478

Neill CC, Trojan T, Parris, Karydis A, Kaste S, Rowland C, Migliorani C. Experience and Expertise Regarding Orthodontic Management of Childhood and Adolescent Cancer Survivors. Am J Orthod Dentofacial Orthop Nov;148(5):765-70, 2015. doi: 10.1016/j.ajodo.2015.05.027  PMID:  26522036

Allen B, Migliorati C, Rowland C, An Q, Shintaku W, DonaldsonM, Wells, M, Kaste S. Comparison of Mandibular Cortical Thickness and QCT-derived Bone Mineral Density (BMD) in Survivors of Childhood Acute Lymphoblastic Leukemia: A Retrospective Study. Int J Paediatr Dent Sept;26(5):330-5, 2016. doi: 10.1111/ipd. 12203. Epub 2015 Sep 15. PMID: 26370921

Gawade PL, Hudson MM, Kaste SC, Neglia JP, Wasilewski-Masker K, Constine LS, Robison LL, Ness KK. A systematic review of selected musculoskeletal late effects in survivors of childhood cancer. Curr Pediatr Rev 10(4):249-62, 2015. PMC4336580.

Robinson GW, Orr BA, Wu G, Gururangan S, Lin T, Qaddoumi I, Packer RJ, Goldman S, Prados MD, Desjardins A, Chingtagumpala M, Tabeke N, Kaste SC, Rusch M, Allen SJ, Onar-Thomas A, Stewart CF, Fouladi M, Boyett JM, Gilbertson RJ, Curran T, Ellison DW, Gajjar A. Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic hedgehog-Subgroup Medulloblastoma: Results from Phase II Pediatric Brain Tumor Consortium Studies – PBTC-025B and PBTC-032. J Clin Oncol 33:2646-2654, 2015. DOI:10.1200/JCO.2014.60.1591. Epub 2015 Jul 13. PMID: 26169613

Kaste SC, Kaufman RA, Sunkara A, Kang G, Morris C, Leung W, Srinivasan A.  Routine pre-and-post-hematopoietic stem cell transplant computed tomography of the abdomen for detecting invasive fungal infection has limited value. Biol Blood Marrow Transplant 21(6):1132-5. doi: 10.1016/j.bbmt.2015.02.023. Epub 2015 Mar 3. PMID: 25748273

Karlage RE, Wilson CL, Zhang N, Kaste SC, Green DM, Armstrong GT, Robison LL, Chemaitilly W, Srivastava K, Hudson MM, Ness KK.  Validity of anthropometric measurements to characterize obesity among adult survivors of childhood cancer:  a report from the St. Jude Lifetime Cohort Study.  Cancer 121:2036-2043, 2015.  Epub 2015 Feb27. PMID: 25728221.

Ness KK, DeLany JP, Kaste SC, Mulrooney DA, Pui CH, Chemaitilly W, Karlage RE, Lanctot JQ, Howell CR, Lu L, Srivastava DK, Robison LL, Hudson MM.  Energy balance in adult survivors of childhood acute lymphoblastic leukemia.  Blood 125(22):3411-3419, 2015. doi: 10.1182/blood-2015-01-621680. Epub 2015 Mar 26.  PMID: 25814529

Kaste SC, Pei D, Cheng C, Neel MD, Bowman WP, Ribeiro RC, Metzger ML, Bhojwani D, Inaba H, Campbell P, Rubnitz JE, Jeha S, Sandlund JT, Downing JR, Relling MV, Pui CH, Howard SC. Utility of early screening magnetic resonance imaging for extensive hip osteonecrosis in pediatric patients treated with glucocorticoids. J Clin Oncol 33:610-615, 2015. doi:10.1200/JCO 2014.57.5480. PMID: 25605853

Federico SM, Brady SL, Pappo S, Wu J, Mao S, McPherson VJ, Young A, Furman WL, Kaufman R, Kaste S. The role of chest computed tomography (CT) as a surveillance tool in children with high-risk neuroblastoma. Pediatr Blood Cancer 62:976-981, 2015 doi: 10.1002/pbc.25598. PMID: 25641708.

Ness KK, Neel MD, Kaste SC, Billups CA, Marchese VG, Rao BN,  Daw NC.  A comparison of function after limb salvage with non-invasive expandable or modular prostheses in children. Eur J Cancer 50:3212-3220, 2014.  PMID:  25459397

Tse BC, Kaste SC, Brennan R, Orr B, Wilson MW. Enophthalmos and choroidal atrophy after intraophthalmic artery chemotherapy for retinoblastoma. Ophthalmology Feb;122(2):435-437, 2015. doi: 10.1016/j.ophtha.2014.09.021. Epub 2014 Oct 22. PMID: 25439599

Ness KK, Kaste SC, Zhu L, Pui CH, Jeha S, Nathan PC, Inaba H, Wasilewski-Maasker K, Shah D, Wells RJ, Karlage RE, Robison LL, Cox CL. Skeletal, neuromuscular and fitness impairments among children with newly diagnosed acute lymphoblastic leukemia. Leuk Lymphoma 56:1004-1011, 2015. PMID: 25030039

Last update: June 2017