Computational researchers develop innovative computer-based methods to answer biological questions through the integration of dry- and wet-lab approaches, cutting-edge software development and interdisciplinary collaboration.
To schedule an interview, email media@stjude.org.
Brain Tumor Experts
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Brian J. Abraham, PhD
Abraham
Brian Abraham, PhD, St. Jude Department of Computational Biology, runs a research program focused on understanding how cells interpret the instructions in DNA to carry out specific tasks. These cellular processes, collected under the field of epigenomic gene regulation, are key drivers of differentiation, are dysregulated in disease and contain several drug targets.
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Paul Geeleher, PhD
Geeleher
Paul Geeleher, PhD, St. Jude Department of Computational Biology, uses new computational methodologies, such as advanced machine learning, to analyze extensive preclinical screening data from cancer cell lines and patient -omics datasets to investigate novel drug targets and potential drug combinations in pediatric cancers.
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Jiyang Yu, PhD, St. Jude Department of Computational Biology interim chair, studies single-cell and spatial systems biology. Yu’s laboratory develops data-driven systems biology algorithms to integrate bulk, single-cell and spatial omics data to reveal hidden drivers underpinning biological processes in health and disease.
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Jinghui Zhang, PhD
Zhang
Jinghui Zhang, PhD, St. Jude Department of Computational Biology, is known for her groundbreaking computational expertise in pediatric cancer genomics. Zhang produces computational tools to help fellow scientists probe the genetic origins and fundamental driving mechanisms of pediatric cancers and researches the genomic landscape of pediatric cancer.
