About the department

The Department of Computational Biology develops innovative computational methods to answer challenging biological questions. Through the integration of dry- and wet-lab approaches, cutting-edge software development, and interdisciplinary collaboration, we generate knowledge and tools to advance the treatment of pediatric cancers and other catastrophic diseases.

Analytical techniques and visualization tools developed through major interdisciplinary efforts like the  St. Jude–Washington University Pediatric Cancer Genome Project (PCGP) have led to major findings about pediatric cancer genomes — including novel driver and predisposing mutations — and the nomination of therapeutic strategies.

Our data-driven approaches are now being used for many clinical applications, including cancer genetic predisposition studies and the development of targeted therapies. Some of these are being assessed in St. Jude-led pediatric clinical trials. To advance cures, we freely share our data analysis software and interactive visualization tools with the global scientific community.

Initiatives and collaborations

Faculty and focus areas


Software engineering

Solving computational biology problems through software engineering, with an emphasis on infrastructure development, clinical analysis support, and tool sharing

Data visualization

Providing the research community with genomic and clinical data visualization and real-time analysis features through our open-source web service, ProteinPaint

Genomics laboratory

Providing method development, laboratory support and next generation sequencing services to the department and its collaborative partners

Administrative team

  • Caleb Simmons - Administrative Director
  • Moe Alqawasmi - Administrative Coordinator
  • Sarah August - Science Research Writer
  • Caitlin Conley de Pastor - Sr Administrative Coordinator
  • Karen Hill - Sr Administrative Specialist
  • Loretta Saulsberry - Grants & Contracts Administrator II
  • Patrece Williams  - Sr Administrative Specialist

Contact us

Department of Computational Biology

MS 1135, Room IA6038
St. Jude Children's Research Hospital

262 Danny Thomas Place
Memphis, TN, 38105-3678 USA
901-595-7069 jiyang.yu@stjude.org

Join us

Explore opportunities in Computational Biology!

262 Danny Thomas Place
Memphis, TN, 38105-3678 USA