Departmental Focus

The Department of Computational Biology develops innovative computational methods to answer challenging biological questions. We accomplish this through the seamless integration of dry-lab and wet-lab approaches.

The department is organized into four synergistic areas:

  • Independent faculty research focused primarily on genomics and epigenetics; image analysis; and systems biology
  • Collaborative multidisciplinary research supporting projects across St. Jude
  • Wet-lab and computing technology development
  • Clinical genomics for St. Jude clinical trials and patient care

Investigators collaborate extensively within the department and across basic research and clinical departments at St. Jude. Our faculty research interests range from cancer genomics to machine learning, single-cell sequencing and network construction.

Through our computational infrastructure, innovative analytical approaches and technology development we have accelerated progress in critical research areas. For example, analytical approaches and visualization tools we developed during the St. Jude – Washington University Pediatric Cancer Genome Project have led to discovery of novel mutations driving pediatric cancers.

Our bioinformatics approaches are now being used for many clinical applications, including cancer genetic predisposition studies and the development of targeted therapies. Some of these are being assessed in St. Jude-led pediatric clinical trials. To advance cures, we freely share data analysis software and visualization tools with the global scientific community.


Jinghui Zhang

Member, St. Jude Faculty
Chair, Department of Computational Biology
St. Jude Endowed Chair in Bioinformatics

Brian Abraham

Assistant Member, St. Jude Faculty
Course Director, Computational Biology, St. Jude Graduate School of Biomedical Sciences

Xiang Chen

Assistant Member, St. Jude Faculty

Paul Geeleher

Assistant Member, St. Jude Faculty

Xiaotu Ma

Assistant Member, St. Jude Faculty

Jiyang Yu

Associate Member, St. Jude Faculty

Xin Zhou

Assistant Member, St. Jude Faculty
Director of Data Visualization

Zhaoming Wang

Associate Member, St. Jude Faculty

Yong Cheng

Assistant Member, St. Jude Faculty

Join us

St. Jude investigators have the freedom to focus on making big discoveries, backed by extraordinary resources and support teams. We are always looking for highly motivated scientists and engineers with passion and talent to join us!

Explore Career Opportunities in Comp Bio

We are currently recruiting!

Contact us

Department of Computational Biology

MS 1135, Room IA6038
St. Jude Children's Research Hospital

262 Danny Thomas Place
Memphis, TN, 38105-3678 USA
262 Danny Thomas Place
Memphis, TN, 38105-3678 USA