St. Jude Research
Interim Chair: Jiyang Yu, PhD

Department of Computational Biology

  

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About the department

The Department of Computational Biology develops innovative computational methods to answer challenging biological questions. Through the integration of dry- and wet-lab approaches, cutting-edge software development, and interdisciplinary collaboration, we generate knowledge and tools to advance the treatment of pediatric cancers and other catastrophic diseases.

Analytical techniques and visualization tools developed through major interdisciplinary efforts like the  St. Jude–Washington University Pediatric Cancer Genome Project (PCGP) have led to major findings about pediatric cancer genomes — including novel driver and predisposing mutations — and the nomination of therapeutic strategies.

Our data-driven approaches are now being used for many clinical applications, including cancer genetic predisposition studies and the development of targeted therapies. Some of these are being assessed in St. Jude-led pediatric clinical trials. To advance cures, we freely share our data analysis software and interactive visualization tools with the global scientific community.

In the news

Initiatives and collaborations

  • St. Jude Cloud

    Sharing data and analysis tools with the global research community

  • PedDep

    Working together to identify genetic and chemical pediatric cancer vulnerabilities

  • iTARGETS

    Identifying novel immunotherapies for pediatric cancer through systems biology

  • Pediatric Cancer Genome Project

    Defining the genomic landscape of pediatric cancer through a historic sequencing effort

  • St. Jude Survivorship Portal

    Empowering researchers to explore, analyze, and share pediatric cancer survivor data

  • COMET

    Creating a leading knowledgebase of pediatric solid tumor epigenetic & histology data

  • The Transcription Collaborative

    Unraveling the nuclear and chromatin architecture driving pediatric cancers

  • Real Time Clinical Genomics

    Making valuable clinical genomic data available on a continuous basis

Computational Biology Faculty

Groups

Software engineering

Solving computational biology problems through software engineering, with an emphasis on infrastructure development, clinical analysis support, and tool sharing

Discover Software Engineering
Data visualization

Providing the research community with genomic and clinical data visualization and real-time analysis features through our open-source web service, ProteinPaint

Dive into data visualization
Genomics laboratory

Providing method development, laboratory support and next generation sequencing services to the department and its collaborative partners

Explore the Genomics Lab

Administrative team

  • Carolyn Reed - Administrative Director
  • Moe Alqawasmi - Administrative Coordinator
  • Sarah August - Science Research Writer
  • Caitlin Conley de Pastor - Sr Administrative Coordinator
  • Karen Hill - Sr Administrative Specialist
  • Loretta Saulsberry - Grants & Contracts Administrator II
  • Patrece Williams  - Sr Administrative Specialist

Contact us

Department of Computational Biology

MS 1135, Room IA6038
St. Jude Children's Research Hospital

262 Danny Thomas Place
Memphis, TN, 38105-3678 USA
901-595-7069 jiyang.yu@stjude.org

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Explore opportunities in Computational Biology!

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262 Danny Thomas Place
Memphis, TN, 38105-3678 USA
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