Jiyang Yu, PhD
Jiyang Yu, PhD

Jiyang Yu, PhD

Assistant Member, St. Jude Faculty



PhD - Columbia University, New York, NY
- Zhejiang University, Hangzhou, China

Research Interests

  • Systems Biology
  • Functional Genomics
  • Immuno-Oncology
  • Translational Oncology

Lab members

Selected Publications

*Co-authorship; #Co-corresponding authorship

Du X, Wei J, Wang Y, Karmaus P, Khatamian A, Tan H, Li Y, Guy C, Nguyen T-LM, Dhungana Y, Neale G, Peng J, Yu J#, Chi H#. Hippo/Mst signaling couples metabolic state and function of CD8α+ dendritic cells for cytotoxic T-cell priming. Nature 2018 (in press).

Rajbhandari P, Lopez G, Capdevila C, Salvatori B, Yu J, Rodriguez-Barrueco R, Martinez D, Yarmarkovich M, Weichert-Leahey N, Abraham BJ, Alvarez MJ, Iyer A, Harenza JL, Oldridge D, Preter KD, Koster J, Asgharzadeh S, Seeger RC, Wei J, Khan J, Vandesompele J, Mestdagh P, Versteeg R, Look AT, Young RA, Iavarone A, Lasorella A, Silva JM, Maris JM, Califano A. Cross-cohort analysis identifies a TEAD4 <-> MYCN positive-feedback loop as the core regulatory element of high-risk neuroblastoma. Cancer Discovery 2018 (in press).

Rodriguez-Barrueco R*, Nekritz E*, Bertucci F, Yu J, Sanchez-Garcia F, Zeleke T, Gorbatenko A, Birnbaum D, Ezhkova E, Cordon-Cardo C, Finetti P, Llobet-Navas D#,  Silva J#. MiR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy. Genes & Development 31:553-566, 2017.

Tosello V, Saccomanni V, Yu J, Bordin F, Amadori A, Ferrando A, Piovan E. Calcineurin complex isolated from T-ALL cells identifies new signaling pathways whose inhibition synergize with Calcineurin inhibition to promote T-ALL cell death. Oncotarget 7 (29), 45715-45729, 2016.

Cheng H, Zhang Z, Rodriguez-Barrueco R, Borczuk A, Liu H, Yu J, Silva J, Cheng S, Perez-Soler R, Halmos B. Functional genomics screen identifies YAP as a key determinant to enhance treatment sensitivity in lung cancer cells. Oncotarget 17;7(20):28976-88, 2016.

Rodriguez-Barrueco R*, Yu J*, Paula-Saucedo L, Olivan M, Llobet-Navas D, Putcha P, Castro V, Murga-Penas E, Castillo-Martin M, Cordon-Cardo C, Kalinsky K, Maurer M, Califano A#, Silva J#. Inhibition of the autocrine loop IL6-JAK2-STAT3-Calprotectin as targeted therapy for HR-/HER2+ breast cancers. Genes & Development 29(15):1631-48, 2015. (Clinical trial NCT02066532 was launched based on this work; featured at Science Signaling, 25 Aug 2015).

Putcha P*, Yu J*, Rodriguez-Barrueco R, Paula-Saucedo L, Villagrasa P, Murga-Penas E, Quayle S, Yang M, Castro V, Llobet-Navas D, Birnbaum D, Finetti P, Woodward W, Bertucci F, Alpaugh M#, Califano A#, Silva J#. HDAC6 activity is a non-oncogene addiction hub for inammatory breast cancers. Breast Cancer Research 17(1):149, 2015. (Clinical trial NCT02632071 was launched and a biomarker patent is being evaluated in the trial based on this work).

Yu J#, Silva J#, Califano A#. ScreenBEAM: a Novel Meta-Analysis Algorithm for Functional Genomics Screens via Bayesian Hierarchical Modeling. Bioinformatics btv556, 2015.

Yu J#, Putcha P, Silva J#. Recovery Drug-Induced Apoptosis Subnetwork from Connectivity Map Data. BioMed Research International 2015:708563, 2015.

Tosello V, Bordin F, Yu J, Agnusdei V, Indraccolo S, Basso G, Amadori A, Piovan E. Calcineurin and GSK-3 inhibition sensitizes T-cell acute lymphoblastic leukemia cells to apoptosis through XIAP degradation. Leukemia 30:812-822, 2015.

O'Brien S, Chen L, Zhong W, Armellino D, Yu J, Loreth C, Follettie M, Damelin M. TGFB exerts opposing e_ects on breast cancer cells that survive chemotherapy versus hypoxia. Cancer Research 75(21):4605-16, 2015.

Sato M, Rodriguez-Barrueco R, Yu J, Do C, Silva J, GautierJ. MYC is a critical target of FBXW7. Oncotarget 20;6(5):3292-305, 2015.

Piovan E*, Yu J*, Tosello V, Castillo M, Indraccolo S, Paietta E, Racevskis J, Rowe J, Tallman M, Meijerink J, Cordon-Cardo C, Califano A#, Ferrando A#. Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia. Cancer Cell 24(6):766-76, 2013.

Yu J, Putcha P, Califano A, Silva J. Pooled ShRNA Screenings: Computational Analysis. Methods in Molecular Biology, 980:371-84, 2013.

Lv B*, Yu J*, Xu J, Chen J, Lai M. A novel approach to detect differentially expressed genes from tag-based digital databases with introducing normalization of housekeeping genes. Genomics 94(3):211-216, 2009.

Last update: April 2018