Immunotherapy uses the body’s immune system to fight cancer cells and comes in many different forms. One type boosts the overall immune system, while another trains the immune system to find and kill specific cancer cells.
The following immunotherapy experts are available to offer credible information, hands-on expertise and clinical insight on developing and testing immunotherapy to treat cancer.
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Stephen Gottschalk, MD, is the Bone Marrow Transplantation and Cellular Therapy chair at St. Jude Children's Research Hospital. His research focuses on cancer immunotherapy, cell therapy and stem cell transplantation. Gottschalk leads a team of clinical and scientific researchers who are conducting clinical studies with highly specific T cells for patients with blood cancers and severe combined immunodeficiency (SCID), as well as brain and other solid tumors. The Gottschalk laboratory is focused on Epstein-Barr virus (EBV)-specific T cells for the treatment of EBV-associated cancers, and the use of genetically modified T cells for cancer immunotherapy. Gottschalk can also speak on the successful cure, pioneered at St. Jude, of X-linked severe combined immunodeficiency disease (SCID), also known as Bubble Boy Disease.
Douglas Green, PhD, is the Immunology chair at St. Jude Children’s Research Hospital. His research focuses on central mechanisms of apoptosis in cancer and the immune system. He discovered that disabling a process that scavenger immune cells use to digest dead and dying tumor cells transformed them from housecleaners to cancer fighters. He is working on reprogramming these macrophages to block LAP, short for LC3-associated phagocytosis. His most recent book, Apoptosis and Other Cell Death Mechanisms: Means to an End, details how cells die, why they die, what happens after they die, and the consequences of such processes for health and disease. Ranked as one of the most cited researches by the Web of Science Group, Green can provide considerable insight on cutting-edge research in immunology.
Shondra Pruett-Miller, PhD, is the Center for Advanced Genome Engineering director and a faculty assistant member of Cell and Molecular Biology. Her research focuses on identifying, validating and delivering new genome editing applications and technologies, such as CRISPR/Cas9. Pruett-Miller can provide information associated with genetic predispositions associated with certain childhood cancers, stem cell research and current immunotherapy initiatives to create more effective treatments catered directly to each child.