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Daniel Moreira, MD
Daniel Moreira, MD

Daniel Moreira, MD

Instructor, St. Jude Faculty

  • Director, Global Professional Education



MD – Tecnológico de Monterrey, Monterrey, Mexico
Internship and Residency – Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
Pediatric Hematology/Oncology Fellowship – Children’s Hospital Colorado, Aurora, Colorado
Global Health Fellowship - St. Jude Children’s Research Hospital, Memphis, Tennessee
Pediatric Neuro-Oncology Fellowship - St. Jude Children’s Research Hospital, Memphis, Tennessee

Honors & Awards

  • 2013 HONORS (Hematology Opportunities for the Next Generation of Research Scientists) Award, American Society of Hematology                                                      
  • 2014 Blackfan Research Award, Cincinnati Children’s Hospital Medical Center

Research Interests

  • Global pediatric oncology
    • improving the outcome of children with cancer in low-and middle-income countries through evidence-based education and workforce optimization
  • Pediatric neuro-oncology
    • improving the survival and reducing the morbidity of children with central nervous system tumors across the world through resource-level adjusted approaches

Selected Publications

Moreira DC, Gajjar A. Precision Medicine for Pediatric Central Nervous System Tumors. Expert Rev Precis Med Drug Dev Feb 13;4(2):55-57, 2019.

Jimenez-Gomez A, Moreira DC, Leon-Astudillo C. Should I stay or should I go? International Medical Graduates in pediatrics. JAMA Pediatrics Jan 22;173(3):217-218, 2019.

Moreira DC, Cost CR, Greffe BS, Macy ME, Garrington TP. Central nervous system involvement of rhabdomyosarcoma: a single institution experience. J Pediatr Hematol Oncol Mar;41(2):152-154, 2019.

Witt DA, Donson AM, Amani V, Moreira DC, Sanford B, Hoffman LM, Handler MH, Mulcahy Levy JM, Jones KL, Nellan A, Foreman NK, Griesinger AM. Specific Expression of PD-L1 in RELA-Fusion Supratentorial Ependymoma: Implications for PD-1 Targeted Therapy. Pediatr Blood Cancer May;65(5):e26960, 2018.

Griesinger AM, Witt DA, Grob ST, Georgio Westover SR, Donson AM, Mulcahy Levy JM, Wong R, Moreira DC, Balakrishnan I, Handler MH, Vibhakar R, Venkataraman S, Foreman NK. Epigenetic silencing of LDOC1 leads to NF-kB hyperactivation in posterior fossa group A ependymoma. Neuro Oncol Oct 1;19(10):1350-1360, 2017.

Sanchez E, Gonzalez EA, Moreno DS, Cardenas RA, Ramos MA, Davalos AJ, Manllo J, Rodarte AI, Petrova Y, Moreira DC, Chavez MA, Tortoriello A, Lara A, Gutierrez BA, Burns AR, Heidelberger R, Adachi R. Syntaxin 3, but not Syntaxin 4, is required for mast cell regulated exocytosis, where it plays a primary role in compound exocytosis. J Biol Chem Mar 1;294(9):3012-3023, 2019.

Rodarte EM, Ramos M, Davalos A, Moreira DC, Moreno D, Cardenas E, Rodarte E, Petrova Y, Molina S, Rendon L, Sanchez E, Breaux K, Tortoriello A, Manllo J, Gonzalez E, Tuvim M, Dickey B, Burns A, Heidelberger R, Adachi R. Control of Mast Cell Regulated Exocytosis by Munc13 Proteins. J Biol Chem Jan 5;293(1):345-358, 2018.

Mizukawa B, O'Brien E, Moreira DC, Wunderlich M, Duan X, Liu W, Orr E, Grimes HL, Zheng Y, Mulloy J. Cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation. Blood Sep 14;130(11):1336-1346, 2017.

Moreira DC, Ng CJ, Quinones R, Liang X, Chung DW, Di Paola J. Microangiopathic Hemolytic Anemia Due to ADAMTS13 Loss in Idiopathic Systemic Capillary Leak Syndrome. J Thromb Haemost Dec;14(12):2353-2355, 2016.

Yang Y, Ahn Y, Gibbons D, Zang Y, Lin W, Thilaganathan N, Moreira DC, Creighton C, Gregory P, Goodall G, Kurie J. The Notch ligand Jagged2 promotes tumor metastasis by activating a double-negative feedback loop involving GATA3 and microRNA-200. J Clin Invest 121:1373-85, 2011.

Melicoff E, Sansores-Garcia L, Gomez A, Moreira DC, Datta P, Thakur P, Petrova Y, Siddiqi T, Murthy JN, Dickey BF, Heidelberger R, Adachi R. Synaptotagmin-2 controls regulated exocytosis but not other secretory responses of mast cells. J Biol Chem 284:19445-51, 2009.

Thakurdas SM, Melicoff E, Sansores-Garcia L, Moreira DC, Petrova Y, Stevens RL, Adachi R. The mast cell tryptase mMCP-6 has a critical immunoprotective role in bacterial infections. J Biol Chem 282:809-15, 2007.

Last update: September 2019