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Kiel D. Neumann, PhD
Kiel Neumann, PhD

Kiel Neumann, PhD

Assistant Member, St. Jude Faculty

Departments

Education

BS (Chemistry) - University of Nebraska, Omaha
BS (Biology) - University of Nebraska, Omaha
PhD (Chemistry) - University of Nebraska, Lincoln

Honors & Awards

  • 2020  Academy Council for Early Career Investigators in Imaging (CECI2). Nominated and accepted in January 2020.
  • 2018  Core of the Year – University of Virginia School of Medicine Radiochemistry Core (Director)  
  • 2018  Basic/translational science in UVA Radiology Research Week Symposium (1st place) 
  • 2017  “Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. Sci. Rep. 7:7903-7910, 2017” highlighted as the top story in the SNMMI Smartbrief August 31, 2017. 
  • 2014  Nebraska Admiralship - highest honor bestowed to Nebraska citizen-conferred by Nebraska governor for extraordinary contribution to science in the State of Nebraska 
  • 2012  Young Investigator Award (3rd Place) in Basic Science, Society of Nuclear Medicine 
  • 2012  Young Professional’s Committee Award (2nd Place) for Basic Science, Society of Nuclear Medicine 
  • 2011  Entrepreneurial lead – Ground Fluor Pharmaceuticals, National Science Foundation I-Corps Program

Research interests

  • Translational Imaging and radiopharmaceutical development

Selected Publications

McCauley KS, Wilde JH, Bufalino SM, Neumann KD. An automated radiosynthesis of [18F]DPA-714 on a commercially available radiosynthesizer, Elixys Flex/Chem. Applied Radiation and Isotopes, 180:110032-110035, 2022.

Sheybani ND, Breza VR, Paul S, McCauley KS, Berr SS, Miller GW, Neumann KD, Price RJ. ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma. Journal of Controlled Release 331:19-29, 2021. doi.org/10.1016/j.jconrel.2021.01.023

Neumann KD, Blecha JE, Chao C-K, Huynh T, Zinn KR, VanBrocklin HF, Thompson CM, Gerdes JM. Dose Formulation, Biodistribution and PET Imaging Studies of a First-In-Class Fluorine-18 Organophosphorus Cholinesterase Inhibitor Tracer in Rat. Current Chemical Biology 14(4):289-303, 2020.

Vāvere AL, Neumann KD, Butch ER, Hu B, DiMagno SG, Snyder SE.  Improved, one-pot synthesis of 6-[18F]fluorodopamine and quality control testing for use in patients with neuroblastoma. J Labelled Comp Radiopharm 14:1069-1080, 2018.

Jordan CD, Han M, Kondapavulur S, Vera DB, Neumann KD, Moore T, Stillson C, Krug R, Behr S, Seo Y, VanBrocklin HF, Larson PEZ, Wilson M, Martin AJ, Hetts SW. Quantification of 89 Zr-Iron oxide nanoparticle biodistribution using PET-MR and ultrashort TE sequences. J Magn Reson Imaging 6:1717-1720, 2018.

Neumann KD, Blecha JE, Hayes TR, Huynh T, Chao C-K, Guilloteau N, Zinn KR, VanBrocklin HF, Thompson CM, Gerdes JM. Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [11C]2-Pyridinealdoxime Methiodide ([11C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication. ACS Chem Neurosci 9:3007-3014, 2018.

Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha JE, Carroll V, Teglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK*, Neumann KD*, Wilson DM*.  [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism. ACS Infect Dis 4:1067-1072, 2018.

Sriram R, Sun J, Villanueva-Meyer J, Mutch C, De Los Santos J, Peters J,  Korenchan DE, Neumann KD, Van Criekinge M, Kurhanewicz J, Rosenberg O,  Wilson DM, Ohliger MA. Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-13C]Pyruvate. ACS Infect Dis 4:797-805, 2018.

Neumann KD, Flavell RF, Wilson DM. Exploring Metabolism In Vivo Using Endogenous 11C Metabolic Tracers. Semin Nucl Med 47:461-473, 2017.

Neumann KD, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF. An Improved Radiosynthesis of O-(2-[18F]Fluoroethyl)-O-(p-nitrophenyl)methylphosphonate: A First-in-Class Cholinesterase PET Tracer. J Label Compd Radiopharm 60:337-342, 2017.

Kondapavulur S, Cote AM, Neumann KD, Jordan  CD, McCoy D, Mabray MC, Liu D, Sze C-H, Gautam A, VanBrocklin HF, Wilson M, Hetts SW. Optimization of an endovascular magnetic filter for maximized capture of magnetic nanoparticles. Biomed Microdevices 18:1-13, 2016.

Neumann KD, Qin L, Vavere AL, Shen B, Miao Z, Chin FT, Shulkin BL, Snyder SE, DiMagno SG. Efficient automated syntheses of high specific activity 6-[18F]fluorodopamine using a diaryliodonium salt precursor. J Label Compd Radiopharm 59:30-34, 2016.

Korenchan DE, Flavell RR, Baligand C, Sriram R, Neumann KD, Sukumar S, VanBrocklin H, Vigneron DB, Wilson DM, Kurhanewicz J. Dynamic nuclear polarization of biocompatible 13C-enriched carbonate for in vivo pH imaging. Chem Commun 52:3030-3033, 2016.

Qin L, Hu B, Neumann KD, Linstad EJ, McCauley K, Veness J, Kempinger JJ, DiMagno SG. A mild and general one-pot synthesis of densely functionalized diaryliodonium salts. Eur J Org Chem 27:5919-5924, 2015.

Hu B, Vavere AL, Neumann KD, Shulkin BL, DiMagno SG, Snyder SE. A Practical, Automated Synthesis of meta-[18F]Fluorobenzylguanidine for Clinical Use. ACS Chem Neurosci 6:1870-1879, 2015.

Hu B, Miller WH, Neumann KD, Linstad EJ, DiMagno SG, An Alternative to the Sandmeyer Approach to Aryl Iodides. Chem Eur J 56:1-6, 2015.

Kuik W-J, Kema IP, Brouwers AH, Zijlma R, Neumann KD, Dierckx RAJO, DiMagno SG, Elsinga PH. In Vivo Biodistribution of No-Carrier-Added 6-18F-Fluoro-3,4-Dihydroxy-L-Phenylalanine (18F-DOPA), Produced by a New Nucleophilic Substitution Approach, Compared with Carrier-Added 18F-DOPA, Prepared by Conventional Electrophilic Substitution. J Nucl Med 56:106-112, 2015.

Graskemper JW, Wang B, Qin L, Neumann KD, DiMagno SG. Unprecedented Directing Group Ability of Cyclophanes in Arene Fluorinations with Diaryliodonium Salts. Org Lett 13:3158-3161, 2011.

Wang B, Qin L, Neumann KD, Uppaluri S, Cerny RL, DiMagno SG. Improved Arene Fluorination Methodology for I(III) Salts. Org Lett 12:3352-3355, 2010.

Last update: August 2022

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