Skip to main content
Melissa Perrino, MD
Melissa Perrino, MD

Melissa Perrino, MD

Instructor, St. Jude Faculty




BS (Microbiology; Philosophy) – The Ohio State University, Columbus, Ohio
MD – Wright State University Boonshoft School of Medicine, Dayton, Ohio
Residency (Pediatrics) – University of Tennessee Health Sciences, Memphis, Tennessee
Fellowship (Pediatric Hematology/Oncology) – Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio

Research Interests

  • Identification of germline variants and their role in driving tumor formation
  • Refining surveillance guidelines for patients with underlying germline predisposition
  • Targetability of tumor and germline variants in cancer therapy and prevention
  • Effects of tumor and germline genomic variants on treatment outcome

Selected Publications

Nagel MB, Perrino MR, Nuccio R, Blake AK, Harrison L, Nichols KE, Pappo AS. Germline genomic findings in children and young adults with melanocytic tumors. Pediatr Blood Cancer. 2023 Jul;70(7):e30361. doi: 10.1002/pbc.30361. Epub 2023 Apr 19. PMID: 37073685.

Kershner LJ, Choi K, Wu J, Zhang X, Perrino M, Salomonis N, Shern JF, Ratner N. Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment. JCI Insight. 2022 Sep 22;7(18):e154513. doi: 10.1172/jci.insight.154513. PMID: 36134665; PMCID: PMC9675562.

MacFarland SP, Maese L, Rednam SP, Kamihara J, Perrino MR, Nichols KE, Brodeur GM, Schiffman JD, Plon SE, Diller LR, Malkin D, Porter CC, Villani A. Collaboration to Promote Research and Improve Clinical Care in the Evolving Field of Childhood Cancer Predisposition. Cancer Prev Res (Phila). 2022 Oct 4;15(10):645-652. doi: 10.1158/1940-6207.CAPR-22-0215. PMID: 36001348.

Perrino MR, Nichols KE, Meade J. Genetic Predisposition to Thyroid Cancer. Advanced Pediatric Thyroid Cancer, Springer Nature 2021 (in press).

Thomson CS, Pundavela J, Perrino MR, Coover RA, Choi K, Chaney KE, Rizvi TA, Largaespada DA, Ratner N. WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth. Oncogene Jun;40(24):4229-4241, 2021. PMID: 34079083

Chaney KE, Perrino MR, Kershner LJ, et al. Cdkn2a loss in a model of neurofibroma demonstrates stepwise tumor progression to atypical neurofibroma and MPNST. Cancer Res Nov 1;80(21):4720-4730, 2020. PMID: 32816910

Perrino M, Cooke-Barber J, Dasgupta R, Geller JI. Genetic predisposition to cancer: Surveillance and intervention. Seminars in Pediatric Surgery 28(6):150858, 2019. PMID: 31931963

Last update: August 2023