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Melissa Perrino, MD
Melissa Perrino, MD

Melissa Perrino, MD

Instructor, St. Jude Faculty




BS (Microbiology; Philosophy) – The Ohio State University, Columbus, Ohio
MD – Wright State University Boonshoft School of Medicine, Dayton, Ohio
Residency (Pediatrics) – University of Tennessee Health Sciences, Memphis, Tennessee
Fellowship (Pediatric Hematology/Oncology) – Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio

Research Interests

  • Identification of germline variants and their role in driving tumor formation
  • Refining surveillance guidelines for patients with underlying germline predisposition
  • Targetability of tumor and germline variants in cancer therapy and prevention
  • Effects of tumor and germline genomic variants on treatment outcome

Selected Publications

Perrino MR, Nichols KE, Meade J. Genetic Predisposition to Thyroid Cancer. Advanced Pediatric Thyroid Cancer, Springer Nature 2021 (in press).

Thomson CS, Pundavela J, Perrino MR, Coover RA, Choi K, Chaney KE, Rizvi TA, Largaespada DA, Ratner N. WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth. Oncogene Jun;40(24):4229-4241, 2021. PMID: 34079083

Chaney KE, Perrino MR, Kershner LJ, et al. Cdkn2a loss in a model of neurofibroma demonstrates stepwise tumor progression to atypical neurofibroma and MPNST. Cancer Res Nov 1;80(21):4720-4730, 2020. PMID: 32816910

Perrino M, Cooke-Barber J, Dasgupta R, Geller JI. Genetic predisposition to cancer: Surveillance and intervention. Seminars in Pediatric Surgery 28(6):150858, 2019. PMID: 31931963

Last update: January 2022