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Division of Cancer Predisposition

Director: Kim E. Nichols, MD


Divisional Focus

The Division of Cancer Predisposition was formed in 2014 with the overarching mission to promote cutting-edge clinical, translational and basic research related to genetic predisposition to childhood cancer. Increasingly, evidence shows that germline mutations in susceptibility genes are associated with a significant proportion of pediatric cancers. By further elucidating why these tumors form, we aim to enhance the clinical care of affected children and their families.

Our division identifies children with a variety of cancer predisposing conditions and provides guidance regarding initial tumor treatment as well as how to best monitor for the subsequent development of additional tumors. This includes confidential genetic counseling and testing for St. Jude patients, and when appropriate, their parents and siblings. We also implement state-of-the-art protocols for cancer surveillance and prevention. Finally, we serve as a resource on cancer genetics and genetic testing to colleagues within St. Jude as well as to outside providers and families.

Our research projects range in scope from identifying novel genetic causes for cancer, to understanding the factors that influence how parents and adolescents make decisions about, communicate and react to cancer genetic testing. We are a collaborative investigative team and look forward to participating in related research projects being undertaken by colleagues in the Solid TumorNeuro-OncologySurvivorshipLeukemia / LymphomaHematology, and Computational Biology programs. We also actively collaborate with external investigators on cancer genetics-related investigations.

Selected Publications

Contact Us

Division of Cancer Predisposition
MS 1170, Room I3311
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678

Phone: (901) 595-4445
Fax: (901) 595-6086

Preferred contact method: email