Wilburn E. Reddick, PhD
Wilburn E. Reddick, PhD

Wilburn E. Reddick, PhD

Member, St. Jude Faculty

  • Director, Diagnostic Image and Signal Processing Laboratory

Departments

Divisions

Education

MS – Memphis State University, Memphis, Tennessee
PhD – Memphis State University, Memphis, Tennessee

Research Interests

Developing and validating quantitative methods used to assess structural brain injury:

  • Tissue segmentation and classification
  • Registration and spatial normalization algorithms for multimodality imaging
  • Diffusion tensor imaging
  • Myelin water imaging
  • Cortical thickness measures

Structure-function relationship of white matter injury as a result of pharmacological or radiological insult through quantitative MR measures:

  • White matter injury attributed to cranial irradiation or chemotherapy
  • Relationship of white matter injury and neurocognitive function
  • Relationship of white matter injury and neurocognitive response to intervention

Assessing solid tumor response to therapy:

  • Pharmacokinetic modeling of dynamic contrast-enhanced MR imaging to assess and predict solid tumor response

Selected Publications

Sabin ND, Cheung YT, Reddick WE, Bhojwani D, Liu W, Glass JO, Brinkman TM, Hwang SN, Srivastava D, Pui C-H, Robison LL, Hudson MM, Krull KR. The impact of persistent leukoencephalopathy on brain white matter microstructure in long-term survivors of acute lymphoblastic leukemia treated with chemotherapy only. Am J Neurorad  2018 (in press).

Cheung YT, Khan RB, Liu W, Brinkman TM, Edelmann MN, Reddick WE, Pei D, Panoskaltsis-Mortari A, Srivastava D, Cheng C, Robison LL, Hudson MM, Pui C-H, Krull KR. Association of cerebrospinal fluid biomarkers of central nervous system injury with neurocognitive and brain imaging outcomes in children receiving chemotherapy for acute lymphoblastic leukemia. JAMA Oncol 4(7):e180089, 2018.

Davis JC, Daw NC, Navid F, Billups CA, Wu J, Bahrami A, Jenkins JJ, Snyder SE, Reddick WE, Santana VM, Shulkin BL. FDG uptake during early adjuvant chemotherapy predicts histologic response in pediatric and young adult patients with osteosarcoma. J Nucl Med 59(1):25-30, 2018.

Kesler SR, Ogg R, Reddick WE, Phillips N, Scoggins M, Glass JO, Cheung YT, Pui CH, Robison LL, Hudson MM, Krull KR. Brain network connectivity and executive function in long-term survivors of childhood acute lymphoblastic leukemia. Brain Connectivity 8(6):333-342, 2018.

Walker BS, Conklin HM, Anghelescu DL, Hall LP, Reddick WE, Ogg RJ, Jacola LM. Parent perspectives and preferences for strategies regarding non-sedated MRI scans in a pediatric oncology population. Journal of Supportive Care in Cancer 26(6):1815-1824, 2018.

Glass JO, Ogg RJ, Hyun JW, Harreld JH, Schreiber JE, Palmer SL, Li Y, Gajjar AJ, Reddick WE. Disrupted development and integrity of frontal white matter in patients treated for pediatric medulloblastoma. Neuro-Oncology 19(10):1408-1418, 2017.

Svolos P, Reddick WE, Edwards A, Sykes A, Li Y, Glass JO, and Patay Z. Measurable supratentorial white matter volume changes in patients with DIPG treated with an anti-VEGF agent, steroids, and radiation. Am J Neuroradiol 38(6):1235-1241, 2017.

Maier-Hein KH, Neher PF, Houde J-C, Côté M-A, Garyfallidis E, Zhong J, Chamberland M, Yeh F-C, Lin Y-C, Ji Q, Reddick WE, Glass JO, Chen DQ, et al. The challenge of mapping the human connectome based on diffusion tractography. Nat Commun 8(1):1349, 2017.

Nassar SL, Conklin HM, Zhou Y, Ashford JM, Reddick WE, Glass JO, Laningham FH, Jeha S, Cheng C, Pui C-H. Neurocognitive outcomes among children who experienced seizures during treatment for acute lymphoblastic leukemia. Pediatr Blood Cancer 64(8):e26436, 2017.

Cheung YT, Sabin ND, Reddick WE, Bhojwani D, Liu W, Brinkman TM, Glass JO, Hwang SN, Srivastava D, Pui CH, Robison LL, Hudson MM, Krull KR. Leukoencephalopathy and long-term neurobehavioral, neurocognitive and brain imaging outcomes in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy: a longitudinal analysis. Lancet Haematol 3(10):e456-e466, 2016.

Guo J, Patay Z, Reddick WE. Fast frequency–sweep spectroscopic imaging with an ultra-low flip angle. Scientific Reports 6:30066, 2016.

Clerk-Lamalice O, Reddick WE, Li Y, Edwards A, Glass JO, Patay Z. MRI evaluation of non-necrotic T2-hyperintense foci in pediatric diffuse intrinsic pontine glioma. Am J Neuroradiol 37(10):1930-1937, 2016.

Krull KR, Cheung YT, Liu W, Fellah S, Reddick WE, Brinkman TM, Kimberg C, Ogg RJ, Srivastava D, Pui C-H, Robison LL, Hudson MM. Chemotherapy pharmacodynamics, neuroimaging and neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia. J Clin Onc 34(22):2644-53, 2016.

Jacola LM, Krull K, Pui C-H, Pei D, Cheng C, Reddick WE, Conklin HC. Longitudinal assessment of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia treated on a contemporary chemotherapy protocol. J Clin Onc 34(11):1239-47, 2016.

Guo J, Glass JO, McCarville MB, Shulkin BL, Daryani VM, Stewart CF, Wu J, Mao S, Dwek JR, Fayad LM, Madewell JE, Navid F, Daw NC, Reddick WE. Assessing vascular effects of adding bevacizumab to neoadjuvant chemotherapy in osteosarcoma using DCE-MRI. Brit J Cancer 113(9):1282-8, 2015.

Helton KJ, Glass JO, Reddick WE, Paydar A, Zandieh AR, Dave R, Smeltzer MP, Wu S, Hankins J, Aygun B, Ogg RJ. Comparing segmented ASL perfusion of vascular territories using manual vs. semi-automated techniques in children with sickle cell anemia. J Mag Reson Imaging 41:439–46, 2015.

Wright KD, Panetta JC, Onar-Thomas A, Reddick WE, Patay Z, Qaddoumi I, Broniscer A, Robinson G, Boop FA, Klima P, Ward D, Gajjar A, Stewart CF. Delayed methotrexate excretion in infants and young children with primary central nervous system tumors and postoperative fluid collections. Cancer Chemoth Pharm 75(1):27-3, 2015.

Jacola LM, Ashford JM, Reddick WE, Glass JO, Ogg RJ, Merchant TM, Conklin HM. The relationship between working memory and cerebral white matter volume in survivors of childhood brain tumors treated with conformal radiation therapy. J Neuro-Oncology 119(1):197-205, 2014.

Edelmann MN, Krull KR, Liu W, Glass JO, Ji Q, Ogg RJ, Sabin ND, Srivastava DK, Robison LL, Hudson MM, Reddick WE. Diffusion tensor imaging and neurocognition in survivors of childhood acute lymphoblastic leukemia. Brain 137(Pt 11):2973-83, 2014.

Reddick WE, Taghipour DJ, Glass JO, Ashford J, Xiong X, Wu S, Bonner M, Khan RB, Conklin HM. Prognostic factors that increase the risk for reduced white matter volumes and deficits in attention and learning for survivors of childhood cancers. Pediatr Blood Cancer 61(6):1074-1079, 2014.

Bhojwani D, Sabin ND, Pei D, Yang JJ, Khan R, Panetta C, Krull KR, Inaba H, Rubnitz JE, Metzger ML, Howard SC, Ribeiro RC, Cheng C, Reddick WE, Jeha S, Sandlund JT, Evans WE, Pui CH, Relling MV. Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia. J Clin Onc 32(9):949-59, 2014.

Shan ZY, Leiker AJ, Onar A, Li Y, Feng T, Reddick WE, Shulkin BL. Cerebral glucose metabolism on positron emission tomography of children. Human Brain Mapp 35(5):2297-2309, 2014.

Last update: September 2018