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Wilburn E. Reddick, PhD
Wilburn E. Reddick, PhD

Wilburn E. Reddick, PhD

Member, St. Jude Faculty

  • Interim Chief, Diagnostic Imaging Research Division
  • Director, Structural and Connectivity Imaging Research (SCIR) Hub



MS – Memphis State University, Memphis, Tennessee
PhD – Memphis State University, Memphis, Tennessee

Research Interests

Developing and validating quantitative methods used to assess structural brain injury:

  • Tissue segmentation and classification
  • Registration and spatial normalization algorithms for multimodality imaging
  • Diffusion tensor imaging
  • Myelin water imaging
  • Cortical thickness measures

Structure-function relationship of white matter injury as a result of pharmacological or radiological insult through quantitative MR measures:

  • White matter injury attributed to cranial irradiation or chemotherapy
  • Relationship of white matter injury and neurocognitive function
  • Relationship of white matter injury and neurocognitive response to intervention

Assessing solid tumor response to therapy:

  • Pharmacokinetic modeling of dynamic contrast-enhanced MR imaging to assess and predict solid tumor response

Selected Publications

Campagne O, Huang J, Lin T, Reddick WE, Selvo NS, Onar-Thomas A, Ward D, Robinson G, Gajjar A, Stewart CF. Population pharmacokinetics of methotrexate and 7-hydroxymethotrexate and delayed excretion in infants and young children with brain tumors. Eur J Pharm Sci 193:106669, Feb 1, 2024. PMID: 38070781

Li Y, Wang JX, Zhou GC, Conklin HM, Onar-Thomas A, Gajjar A, Reddick WE, Lu Z-H. Imaging mediation analysis for longitudinal outcomes: a case study of childhood brain tumor survivorship. Statistics and Its Interface Pre-print August 15, 2023.

Wang JX, Li Y, Reddick WE, Conklin HM, Glass JO, Onar-Thomas A, Gajjar A, Cheng C, Lu Z-H. A high-dimensional mediation model for a neuroimaging mediator: integrating clinical, neuroimaging, and neurocognitive data to mitigate late effects in pediatric cancer. Biometrics Sept;.79(3):2430-2443, 2023.

Jacola LM, Conklin HM, Krull KR, Pei D, Cheng C, Reddick WE, Pui C-H, Jeha S. The impact of intensified CNS-directed therapy on neurocognitive outcomes in survivors of childhood ALL treated without cranial irradiation. J Clin Onc 40(36):4218-4227, 2022.

Song R, Hwang SN, Goode C, Storment D, Scoggins M, Abramson Z, Hillenbrand CM, Mandrell B, Krull K, Reddick WE. Assessment of fat fractions in the tongue, soft palate, pharyngeal wall, and parapharyngeal fat pad by the GOOSE and DIXON methods. Invest Rad 57(12):802-809, 2022.

Gandy K, Scoggins MA, Phillips N, van der Plas E, Fellah S, Jacola LM, Pui CH, Hudson MM, Reddick WE, Sitaram R, Krull KR. Sex-based differences in functional brain activity during working memory in long-term survivors of pediatric acute lymphoblastic leukemia. JNCI Cancer Spectr 6(2):pkac026, 2022.

Acharya S, Fuo Y, Patni T, Li Y, Wang C, Gargone M, Ashford JM, Wilson L, Faught A, Reddick WE, Patay Z, Gajjar A, Conklin HM, Merchant TE. Association between brain substructure dose and cognitive outcomes in children with medulloblastoma treated on SJMB03: a step towards substructure-informed planning. J Clin Onc 40(1):83-95, 2022.

Gandy K, Scoggins MA, Jacola LM, Litten M, Reddick WE, Krull KR. Structural and functional brain imaging in long-term survivors of childhood acute lymphoblastic leukemia treated with chemotherapy: A systematic review. JNCI Cancer Spectr 5(5):pkab069, 2021.

Song R, Glass JO, Reddick WE. Modified DTI processing pipeline for archived studies of patients with leukoencephalopathy. J Magn Reson Imaging 54(3):997-1008, 2021.

Keenan KE, Gimbutas Z, Dienstfrey A, Stupic KF, Boss MA, Russek SE, Chenevert TL, Prasad PV, Guo J, Reddick WE, Cecil KM, Shukla-Dave A, Nunez DA, Konar AS, Liu MZ, Jambawalikar SR, Schwartz LH, Zheng J, Hu P, Jackson EF. Multi-site, multi-platform comparison of MRI T1 measurement using the system phantom. PLOS One 16(6): e0252966, 2021.

Pryweller JR, Glass JO, Sabin ND, Laningham FH, Li Y, Jacola LM, Conklin HM, Reddick WE. Characterization of leukoencephalopathy and association with later neurocognitive performance in pediatric acute lymphoblastic leukemia. Invest Rad 56(2):117-126, 2021.

Phillips NS, Kesler SR, Scoggins M, John O. Glass, Cheung YT, Li W, Banerjee P, Ogg RJ, Srivastava D, Pui C-H, Robison LL, Reddick WE, Hudson MM, Krull KR. Connectivity of the cerebello-thalamo-cortical pathway in survivors of childhood leukemia treated with chemotherapy only. JAMA Network Open 3(11):e2025839, 2020.

Banerjee P, Rossi MG, Anghelescu DL, Liu W, Breazeale AM, Reddick WE, Glass JO, Phillips NS, Jacola LM, Sabin ND, Inaba H, Srivastava D, Robison LL, Pui CH, Hudson MM, Krull KR. Anesthesia impact on neurocognitive and neuroimaging outcomes in long-term survivors of childhood acute lymphoblastic leukemia. JAMA Onc 5(10):1456-1463, 2019.

Guo J, Han Y, Li Y, Reddick WE. Reduced brain microstructural asymmetry in patients with childhood leukemia treated with chemotherapy compared with healthy controls. PLOS One 14(5):e0216554, 2019.

Ji Q, Edwards A, Glass JO, Brinkman TM, Patay Z, Reddick WE. Measurement of projections between dentate nucleus and contralateral frontal cortex in human brain via diffusion tensor tractography. Cerebellum 18(4):761-769, 2019.

Al-Fahad R, Yeasin M, Glass JO, Conklin HM, Jacola LM, Reddick WE. Early imaging based predictive modeling of cognitive performance following therapy for childhood ALL. IEEE Access 7:146662-146674, 2019.

Tang TT, Zawaski JA, Kesler SR, Beamish CA, Reddick WE, Glass JO, Carney D, Sabek O, Grosshans D, Gaber MW. A comprehensive preclinical assessment of late-term imaging markers of radiation-induced brain injury. Neuro-Oncology Advances 1(1):vdz012, 2019.

Sabin ND, Cheung YT, Reddick WE, Bhojwani D, Liu W, Glass JO, Brinkman TM, Hwang SN, Srivastava D, Pui C-H, Robison LL, Hudson MM, Krull KR. The impact of persistent leukoencephalopathy on brain white matter microstructure in long-term survivors of acute lymphoblastic leukemia treated with chemotherapy only. Am J Neurorad 39(10):1919-1925, 2018.

Cheung YT, Khan RB, Liu W, Brinkman TM, Edelmann MN, Reddick WE, Pei D, Panoskaltsis-Mortari A, Srivastava D, Cheng C, Robison LL, Hudson MM, Pui C-H, Krull KR. Association of cerebrospinal fluid biomarkers of central nervous system injury with neurocognitive and brain imaging outcomes in children receiving chemotherapy for acute lymphoblastic leukemia. JAMA Oncol 4(7):e180089, 2018.

Kesler SR, Ogg R, Reddick WE, Phillips N, Scoggins M, Glass JO, Cheung YT, Pui CH, Robison LL, Hudson MM, Krull KR. Brain network connectivity and executive function in long-term survivors of childhood acute lymphoblastic leukemia. Brain Connectivity 8(6):333-342, 2018.

Glass JO, Ogg RJ, Hyun JW, Harreld JH, Schreiber JE, Palmer SL, Li Y, Gajjar AJ, Reddick WE. Disrupted development and integrity of frontal white matter in patients treated for pediatric medulloblastoma. Neuro-Oncology 19(10):1408-1418, 2017.

Maier-Hein KH, Neher PF, Houde J-C, Côté M-A, Garyfallidis E, Zhong J, Chamberland M, Yeh F-C, Lin Y-C, Ji Q, Reddick WE, Glass JO, Chen DQ, et al. The challenge of mapping the human connectome based on diffusion tractography. Nat Commun 8(1):1349, 2017.

Last update: March 2024