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Akshay Sharma, MBBS
Akshay Sharma, MBBS

Akshay Sharma, MBBS

Instructor, St. Jude Faculty

Departments

Education

MBBS – Kasturba Medical College, Manipal University, Mangalore, India
Postdoctoral Fellowship – Emory University, Winship Cancer Center, Atlanta, Georgia
Residency – University of Kentucky, Lexington, Kentucky
Clinical Fellowship St. Jude Children’s Research Hospital, Memphis, Tennessee

Honors & Awards

  • 2019  Young Investigator Award, American Society of Pediatric Hematology/Oncology (ASPHO)
  • 2019  Young Investigator Travel Award, Pediatric Blood & Marrow Transplant Consortium

Research Interests

  • Gene therapy and gene editing.
  • Bone marrow transplantation for patients with non-malignant hematological conditions.
  • Development of novel reduced intensity and non-myeloablative conditioning regimens.

Selected Publications

Sharma A, Badawy SM, Suelzer EM, Murthy HS, Prasad P, Eissa H, Carpenter PA, Hamadani M, Labopin M, Schoemans H,  Tichelli A, Phelan R, Hamilton BK, Buchbinder D, Im A, Hunter R, Brazauskas R, Burns LJ. Systematic reviews in hematopoietic cell transplantation and cellular therapy: considerations and guidance from the American Society for Transplantation and Cellular Therapy, European Society for Blood and Marrow Transplantation, and the Center for International Blood and Marrow Transplant Research late effects and quality of life working committee. Bone Marrow Transplant Jan 29, 2021. doi: 10.1038/s41409-020-01199-1. Online ahead of print.

Frangoul H, Altshuler D, Cappellini MD, Chen YS, Domm J, Eustace BK, Foell J, de la Fuente J, Grupp S, Handgretinger R, Ho TW, Kattamis A, Kernytsky A, Lekstrom-Himes J, Li AM, Locatelli F, Mapara MY, de Montalembert M, Rondelli D, Sharma A, Sheth S, Soni S, Steinberg MH, Wall D, Yen A, Corbacioglu S. CRISPR-Cas9 gene editing for sickle cell disease and β-thalassemia.  N Engl J Med Jan 21;384(3):252-260, 2021. doi: 10.1056/NEJMoa2031054. Epub 2020 Dec 5.

Sharma A, Bhatt NS, St Martin A, Abid MB, Bloomquist J, Chemaly RF, Dandoy C, Gauthier J, Gowda L, Perales MA, Seropian S, Shaw BE, Tuschl EE, Zeidan AM, Riches ML, Shah GL. Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: An observational cohort study. Lancet Haematol Jan 19;S2352-3026(20)30429-4, 2021. doi: 10.1016/S2352-3026(20)30429-4. Online ahead of print.

Sharma A, Bhakta N, Johnson LM. Germline gene editing for sickle cell disease. Am J Bioeth. Aug;20(8):46-49, 2020. doi: 10.1080/15265161.2020.1781970.

Sharma A, Johnson LM. Bringing known drugs to pediatric research: Safety, efficacy, and the ambiguous minor increase in minimal risk. Am J Bioeth May;20(4):106-108, 2020. doi: 10.1080/15265161.2020.1730485.

Uchida N, Leonard A, Stroncek D, Panch SR, West K, Molloy E, Hughes TE, Hauffe S, Taylor T, Fitzhugh C, Hankins JS, Wilson M, Sharma A, Tsai SQ, Weiss MJ, Hsieh M, Tisdale JF. Safe and efficient peripheral blood stem cell collection in patients with sickle cell disease using plerixafor. Haematologica. Feb 13; 105 (10): 236182, 2020. doi: 10.3324 / haematol.2019.236182. Online ahead of print. 

Métais JY, Doerfler PA, Mayuranathan T, Bauer DE, Fowler SC, Hsieh MM, Katta V, Keriwala S, Lazzarotto CR, Luk K, Neel MD, Perry SS, Peters ST, Porter SN, Ryu BY, Sharma A, Shea D, Tisdale JF, Uchida N, Wolfe SA, Woodard KJ, Wu Y, Yao Y, Zeng J, Pruett-Miller S, Tsai SQ, Weiss MJ. Genome editing of HBG1 and HBG2 to induce fetal hemoglobin. Blood Adv. Nov 12;3(21):3379-3392, 2019. doi: 10.1182/bloodadvances.2019000820.

Swimm A, Giver CR, DeFilipp Z, Rangaraju S, Sharma A, Ulezko Antonova A, Sonowal R, Capaldo C, Powell D, Qayed M, Kalman D, Waller EK.  Indoles derived from intestinal microbiota act via type I interferon signaling to limit graft-versus-host disease.  Blood. Dec 6;132(23):2506-2519, 2018. doi: 10.1182/blood-2018-03-838193. Epub Sep 26, 2018

Sharma A, Kang G, Sunkara A, Inaba H, Jeha S, Cross SJ, Geiger T, Triplett B. Haploidentical donor transplantation using a novel clofarabine-containing conditioning regimen for very high-risk hematologic malignant neoplasms. J Pediatr Hematol Oncol. Nov;40(8):e479-e485, 2018. doi: 10.1097/MPH.0000000000001222.

Sharma A, Johnson LM, Caruso Brown A, Unguru Y, Lantos JD. An extravagant gift from a grateful patient. Pediatrics. Jun;141(6):e20172837, 2018. doi: 10.1542/peds.2017-2837. Epub May 4, 2018.

Sharma A, Kang G, Sunkara A, Inaba H, Jeha S, Cross SJ, Geiger T, Triplett B. Haploidentical donor transplantation using a novel clofarabine-containing conditioning regimen for very high-risk hematologic malignant neoplasms. Journal of Pediatric Hematology and Oncology 2018 doi: 10.1097/MPH.0000000000001222. PubMed PMID: 29750747.

Sharma A, Geiger TL, Federico S, Kamens J, Giles F, Cunningham L. Hypocalcemic tetany after transfusion of a small amount of blood product. Journal of Pediatric Hematology and Oncology 39(8):629-632, 2017. PubMed PMID:28902075.

Sharma A, Easow Mathew M, Sriganesh V, Reiss UM. Gene therapy for haemophilia (Revised). Cochrane Database of Systematic Reviews 12:CD010822, 2016. PubMed PMID: 27996087.

Jagannath VA, Fedorowicz Z, Al Hajeri A, Sharma A. Hematopoietic stem cell transplantation for people with ß-thalassaemia major (Revised). Cochrane Database of Systematic Reviews 11:CD008708, 2016. PubMed PMID: 27900772.

Easow Mathew M, Sharma A, Aravindakshan R. Splenectomy for people with thalassaemia major or intermedia. Cochrane Database of Systematic Reviews 6:CD010517, 2016. PubMed PMID: 27296775.

Sharma A, Myers K, Ye Z, D'Orazio J. Dyskeratosis congenita caused by a novel TERT point mutation in siblings with pancytopenia and exudative retinopathy. Pediatric Blood & Cancer 61(12):2302-4, 2014. PubMed ID: 25067791.

Lu Y, Giver CR, Sharma A, Li JM, Darlak KA, Owens LM, Roback JD, Galipeau J, Waller EK. IFN-γ and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity. Blood 119(4):1075-85, 2012. PubMed ID: 22130799.

Sharma A, Dhanashree B. Screening of currency in circulation for bacterial contamination. Current Science 100(6):822-5, 2011.

Last update: February 2021