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Taosheng Chen, PhD, PMP
Taosheng Chen, PhD, PMP

Taosheng Chen, PhD, PMP

Member, St. Jude Faculty

  • Director, High Throughput Bioscience Center



PhD – University of Vermont
MS – Fudan University, Shanghai
BS – Fudan University, Shanghai

Research Interests

  • Regulation of PXR and CAR (nuclear receptors), and CYP3A (drug–metabolizing enzymes) in drug toxicity, drug resistance and human diseases
  • Development of chemical probes and therapeutic leads for PXR, CAR and CYP3A
  • Development of drug discovery technologies
  • High throughput screening (HTS) and high content screening (HCS)

Selected Publications

Garcia-Maldonado E, Huber AD, Chai SC, Nithianantham S, Li Y, Wu J, Poudel S, Miller DJ, Seetharaman J, Chen T. Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun 15(1):4054, 2024.

Huber AD, Poudel S, Wu J, Miller DJ, Lin W, Yang L, Bwayi MN, Rimmer MA, Gee RRF, Seetharaman J, Chai SC, Chen T. A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR. Nucleic Acids Res 52(4):1661-1676, 2024.

Lin W, Huber AD, Poudel S, Li Y, Seetharaman J, Miller DJ, Chen T. Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein. Proc Natl Acad Sci U S A 120(10): e2217804120, 2023.

Bwayi MN, Garcia-Maldonado E, Chai SC, Xie B, Chodankar S, Huber AD, Wu J, Annu K, Wright WC, Lee HM, Seetharaman J, Wang J, Buchman CD, Peng J, Chen T. Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation. Nucleic Acids Res 50(6):3254-3275, 2022.

Wang J, Buchman CD, Seetharaman J, Miller DJ, Huber AD, Wu J, Chai SC, Garcia-Maldonado E, Wright WC, Chenge J, Chen T. Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5. J Am Chem Soc 143(44):18467-18480, 2021.

Lin W, Wang Y-M, Chai SC, Lv L, Zheng J, Wu J, Zhang Q, Wang Y-D, Griffin PR, Chen T. SPA70 is a potent antagonist of human pregnane X receptor. Nat Commun 8:741, 2017.

Last update: June 2024