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Bringing Chemistry to Medicine Symposium

Thursday, July 21, 2022: Transcription Therapy
Friday, July 22, 2022: Frontiers in Chemical Biology

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Join us for the 3rd annual Bringing Chemistry to Medicine symposium, a virtual event featuring talks by leading experts from around the globe working at the interface of chemical and biomedical sciences. Speakers represent expertise across a spectrum of research areas, including therapeutic regulation of transcription and chromatin, computational biology, and chemical biology. The event will span two days with focused themes: Transcription Therapy on Thursday, July 21, 2022, and Frontiers in Chemical Biology, on Friday, July 22, 2022

This symposium, hosted by the St. Jude Department of Chemical Biology and Therapeutics and the St. Jude Comprehensive Cancer Center, is a component of the institution’s strategic objective to establish a global hub focused on the emerging field of transcription-targeted therapeutics.

To enable broad participation and interaction among trainees and scientists around the world, registration is free.

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Please watch this page for coming updates on additional speakers and agenda.


July 21, 2022

image of Scott Armstrong

Scott Armstrong, MD, PhD
Dana-Farber Cancer Institute

photo of Bradley Bernstein

Bradley Bernstein, MD, PhD
Dana Farber Cancer Institute

photo of Clifford Brangwynne

Clifford Brangwynne, PhD
Princeton University

photo of Jolanta Grembecka

Jolanta Grembecka, PhD 
University of Michigan

photo of Tanja Mittag

Tanja Mittag, PhD
St. Jude Children's Research Hospital

photo of Geeta Narlikar

Geeta Narlikar, PhD
University of California, San Francisco

photo of Fraydoon Rastinejad

Fraydoon Rastinejad, PhD
University of Oxford

photo of Ken Zaret

Ken Zaret, PhD
University of Pennsylvania


July 22, 2022

photo of Ray Deshaies

Ray Deshaies, PhD
Amgen, Inc.

photo of Matt Disney

Matt Disney, PhD
Scripps Research Institute (Florida)

photo of Ron Dror

Ron Dror, PhD
Stanford University

photo of Dorothee Kern

Dorothee Kern, PhD
Brandeis University

photo of Judith Klinman

Judith Klinman, PhD
University of California, Berkeley

photo of David Moore

David Moore, PhD
University of California, Berkeley

photo of Peter Schultz

Peter Schultz, PhD
Scripps Research Institute (La Jolla)

photo of Derek Tan

Derek Tan, PhD
Memorial Sloan Kettering Cancer Center


Watch our Archived Lectures

In 2020 and 2021, St. Jude hosted exciting two-day events focused on Transcription Therapy and Chemical Biology and Therapeutics.

Visit our video archive link

Transcription Therapy at St. Jude

Over decades of research, scientists in the St. Jude Comprehensive Cancer Center and others have discovered that several pediatric cancers emerge due to disruption in chromatin and epigenetic states and dysfunctional transcriptional regulation. While gene regulation in general has long been considered “undruggable,” scientists in the St. Jude Department of Chemical Biology & Therapeutics (CBT) have created synthetic gene regulators and are devising new chemical approaches to inhibit or degrade malfunctioning components of chromatin and gene regulatory machineries. This work builds on the history of St. Jude as a pioneer in the therapeutic use of small molecules targeting gene regulation, most notably the application of glucocorticoid receptor agonists into chemotherapy regimens for pediatric patients with acute lymphoblastic lymphoma (ALL). The drugging of this transcription factor helped to dramatically increase overall survival rates for newly diagnosed ALL to 94% at St. Jude.

Learn more about transcription therapy at St. Jude    Learn more