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Myriam Labelle, PhD
Myriam Labelle, PhD


BSc – Université de Montréal, Canada
MSc – Université du Québec à Montréal, Canada
PhD – Dresden University of Technology, Germany
Postdoctoral Studies – Massachusetts Institute of Technology, Cambridge, Massachusetts

Research Interests

  • Role of the microenvironment during cancer metastasis
  • Influence of platelets on tumor cell behavior
  • Platelet-derived factors and signals involved in cancer progression and metastasis

Selected Publications

Jia H, Janjanam J, Wu SC, Wang R, Pano G, Celestine M, Martinot O, Breeze-Jones H, Clayton G, Garcin C, Shirinifard A, Zaske AM, Finkelstein D, Labelle M. The tumor cell-secreted matricellular protein WISP1 drives pro-metastatic collagen linearization. EMBO J. 2019 Aug 15;38(16):e101302. doi: 10.15252/embj.2018101302. Epub 2019 Jul 11. PMID:31294477

Hunt LC, Stover J, Haugen B, Shaw TI, Li Y, Pagala VR, Finkelstein D, Barton ER, Fan Y, Labelle M, Peng J, Demontis F. A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice. Cell Rep. 2019 Jul 30;28(5):1268-1281.e6. doi: 10.1016/j.celrep.2019.06.094. PMID: 31365869

Labelle M, Begum S, Hynes RO. Platelets guide the formation of early metastatic niches. Proc Natl Acad Sci U S A Jul 29;111(30):E3053-61, 2014. PMID:25024172

Yao X, Labelle M, Lamb CR, Dugan JM, Williamson CA, Spencer DR, Christ KR, Keating RO, Lee WD, Paradis GA, Begum S, Hynes RO, Wittrup KD. Determination of 35 cell surface antigen levels in malignant pleural effusions identifies CD24 as a marker of disseminated tumor cells. Int J Cancer Dec 15;133(12):2925-33, 2013. PMID:23775727

Miller PG, Al-Shahrour F, Hartwell KA, Chu LP, Järås M, Puram RV, Puissant A, Callahan KP, Ashton J, McConkey ME, Poveromo LP, Cowley GS, Kharas MG, Labelle M, Shterental S, Fujisaki J, Silberstein L, Alexe G, Al-Hajj MA, Shelton CA, Armstrong SA, Root DE, Scadden DT, Hynes RO, Mukherjee S, Stegmaier K, Jordan CT, Ebert BL. In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Cancer Cell Jul 8;24(1):45-58, 2013. PMID:23770013

Rezaei M, Friedrich K, Wielockx B, Kuzmanov A, Kettelhake A, Labelle M, Schnittler H, Baretton G, Breier G. tInterplay between neural-cadherin and vascular endothelial-cadherin in breast cancer progression. Breast Cancer Res Dec 6;14(6):R154, 2012. PMID:23216791

Labelle M, Hynes RO. The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination. Cancer Discov Dec;2(12):1091-9, 2012. PMID:23166151

Labelle M, Begum S, Hynes RO. Direct Signaling Between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis. Cancer Cell Nov 15;20(5):576-90, 2011. PMID:22094253

Labelle M, Schnittler HJ, Aust DE, Friedrich K, Baretton G, Vestweber D, Breier G. Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor beta signaling. Cancer Res Mar 1;68(5):1388-97, 2008. PMID:18316602.

Last update: September 2019