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Caitlin Zebley, MD, PhD
Caitlin Zebley, MD, PhD

Caitlin Zebley, MD, PhD

Instructor, St. Jude Faculty



BS (Chemistry, Biology) - Iona College, New Rochelle, NY
MD - Chicago Medical School, North Chicago, IL
Pediatric Residency - University of Minnesota, Minneapolis, MN
Pediatric Hematology/Oncology Fellowship - St. Jude Children’s Research Hospital, Memphis, TN
PhD - St. Jude Graduate School of Biomedical Sciences, Memphis, TN

Research Interests

  • Fundamental mechanisms of T cell biology

Selected Publications

Zebley CC, Brown C, Mi T, Fan Y, Alli S, Boi S, Galletti G, Lugli E, Langfitt D, Metais J-Y, Lockey T, Meagher M, Triplett B, Talleur AC, Gottschalk S, Youngblood B. CD19-CAR T cells undergo exhaustion DNA methylation programming in patients with acute lymphoblastic leukemia. Cell Rep Nov 30;37(9):110079, 2021. doi: 10.1016/j.celrep.2021.110079. PMID: 34852226

Prinzing B, Zebley CC, Petersen CT, Fan Y, Anido AA, Yi Z, Nguyen P, Houke H, Bell M, Haydar D, Brown C, Boi SK, Alli S, Crawford JC, Riberdy JM, Park JJ, Zhou S, Velasquez MP, DeRenzo C, Lazzarotto CR, Tsai SQ, Vogel P, Pruett-Miller SM, Langfitt DM, Gottschalk S, Youngblood B, Krenciute G. Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity. Sci Transl Med Nov 17;13(620):eabh0272, 2021. doi: 10.1126/scitranslmed.abh0272. Epub 2021 Nov 17. PMID: 34788079

Zebley CC, Abdelsamed HA, Ghoneim HE, Alli S, Brown C, Haydar D, Mi T, Harris T, McGargill MA, Krenciute G, Youngblood B. Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation. Cell Rep Oct 12;37(2):109796, 2021. doi: 10.1016/j.celrep.2021.109796. PMID: 34644568

Zebley CC, Gottschalk S, Youngblood B. Rewriting history: Epigenetic reprogramming of CD8+ T cell differentiation to enhance immunotherapy. Trends in Immunology 2020.

Abdelsamed HA*, Zebley CC*, Nguyen H*, Rutishauser RL, Fan Y, Ghoneim H, Crawford JC, Alfei F, Alli S, Ribeiro, SP, Serti E, Castellaw A, McGargill MA, Jin H, Boi SK, Serti E, Turka LA, Busch ME, Stone M, Deeks SG, Sekaly RP, Zehn D, James E, Nepom GT, Youngblood B. Human self-reactive CD8 T cells acquire stem-cell memory-associated epigenetic programs during development of type 1 diabetes. Nature Immunology 21:578-587, 2020.

Fonseca R, Beura LK, Quarnstrom CF, Ghoneim HE, Fan Y, Zebley CC, Scott MC, Fares-Frederickson NJ, Wijeyesinghe S, Thompson EA, da Silva HB, Vezys V, Youngblood B, Masopust D. Developmental plasticity allows outside-in immune responses by resident memory T cells. Nature Immunology 21:412-421, 2020.

Abdesladmed HA, Zebley CC, Youngblood B. Epigenetic maintenance of acquired gene expression programs during memory CD8 T cell homeostasis. Frontiers in Immunology 9:6, 2018.

Abdelsamed HA, Zebley CC, Youngblood B. In vitro Homeostatic Proliferation of Human CD8 T Cells. Bio-protocol 7(22), 2017.

Abdelsamed HA, Moustaki A, Fan Y, Dogra P, Ghoneim HE, Zebley CC, Triplett BM, Sekaly RP, Youngblood B. Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis. Journal of Experimental Medicine 214(6):1593-1606, 2017

Last update: January 2022