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Marcus Fischer, PhD
Marcus Fischer, PhD

Marcus Fischer, PhD

Assistant Member, St. Jude Faculty

  • Adjunct Assistant Professor at the University of Tennessee Health Science Center (Department of Pharmaceutical Sciences)



PhD - University of York, York, UK
MSc - University of Lübeck, Lübeck, Germany
BSc - University of Lübeck, Lübeck, Germany

Research Interests

  • Chemical biology
  • Ligand discovery
  • Structural biology
  • Variable-temperature protein crystallography
  • Protein conformational ensembles
  • Protein flexibility and hydration
  • Protein structure – (mal-)function
  • Molecular docking

Selected Publications

Fischer M. Macromolecular room temperature crystallography. Quarterly Reviews of Biophysics 54: e1, 2021.

Darby JF, Hopkins AP, Shimizu S, Roberts SM, Brannigan JA, Turkenburg JP, Thomas GH, Hubbard RE, Fischer M#. Water networks can determine the affinity of ligand binding to proteins. JACS doi: 10.1021/jacs.9b06275, 2019.

Pottel J, Levit A, Korczynska M, Fischer M, Shoichet BK. The Recognition of Unrelated Ligands by Identical Proteins. ACS Chem Bio 13:2522-2533, 2018.

Balius TE*, Fischer M*, Stein RM, Adler TB, Nguyen CN, Cruz A, Gilson MK, Kurtzman T, Shoichet BK. Testing Inhomogeneous Solvation Theory in Structure-Based Ligand Discovery. PNAS 114:E6839–E6846, 2017.

Lee H, Fischer M, Shoichet BK, Liu S-Y. Hydrogen Bonding of 1,2-Azaborines in the Binding Cavity of T4 Lysozyme Mutants: Structures and Thermodynamics. JACS 138:12021-12024, 2016.

Fischer M, Shoichet BK, Fraser JS. One crystal, two temperatures – Cryocooling Penalties alter Ligand Binding to Transient Protein Sites. ChemBioChem 16:1560-1564, 2015.

Merski M*, Fischer M*, Balius TE*, Eidam O, Shoichet BK. Homologous ligands accommodated by discrete conformations of a buried cavity. PNAS 112:5039-5044, 2015.

Fischer M, Hopkins AP, Severi E, Hawkhead J, Bawdon D, Watts AG, Hubbard RE, Thomas GH. Tripartite ATP-independent periplasmic (TRAP) transporters use an arginine-mediated selectivity filter for high affinity substrate binding. J Biol Chem 290:27113-27123, 2015.

Fischer A, Fischer M, Nicholls RA, Lau S, Poettgen J, Patas K, Heesen C, Gold S. Diagnostic accuracy for major depression in multiple sclerosis using self-report questionnaires. Brain and Behavior 5:e00365, 2015.

Nicholls RA, Fischer M, McNicholas S, Murshudov GN. Conformation-independent structural comparison of macromolecules with ProSMART. Acta Cryst D 70:2487-2499, 2014.

Fischer M*, Coleman RG*, Fraser JS, Shoichet BK. Incorporating protein flexibility and conformational energy penalties in docking screens to improve ligand discovery. Nature Chem 6:575-583, 2014.

Rocklin GJ*, Boyce SE*, Fischer M*, Fish I, Mobley DL, Shoichet BK, Dill KA. Blind prediction of charged ligand binding affinities in a model binding site. J Mol Biol 25:4569-4583, 2013.

Barelier S, Boyce SE, Fish I, Fischer M, Goodin DB, Shoichet BK. Roles for Ordered and Bulk Solvent in Ligand Recognition and Docking in Two Related Cavities. PLoS One 8:e69153, 2013.

Nicholls R A, Fischer M, Murshudov GN. An Overview of ProSMART. CCP4 Newsletter on Protein Crystallography 48, 2012.

Fischer M, Leech AP, Hubbard RE. Comparative Assessment of Different Histidine Tags for Immobilization of Protein onto Surface Plasmon Resonance Sensorchips. Anal Chem 83:1800-1807, 2011.

Mulligan C, Fischer M, Thomas, GH. Tripartite ATP-independent periplasmic (TRAP) transporters in bacteria and archaea. FEMS Microbiol Rev 35:68-86, 2011.

Fischer M, Zhang QY, Hubbard RE, Thomas GH. Caught in a TRAP: substrate binding proteins in secondary transport. Trends Microbiol 18:471-478, 2010.

Fischer M, Hubbard RE. Fragment-based ligand discovery. Mol Interv 9:22-30, 2009.

Last update: February 2021