Terrence Geiger, MD, PhD
Terrence L. Geiger, MD, PhD

Terrence L. Geiger, MD, PhD

Member, St. Jude Faculty

  • Senior Vice President and Deputy Director for Academic and Biomedical Operations
  • Medical Director, Blood Bank, Blood Donor Center & HLA
  • St. Jude Endowed Chair in Pediatrics



MD – Yale University (1993)
PhD – Yale University (1993)

Research Interests

  • Immune regulation
  • Autoimmunity
  • Cellular immunotherapy

Clinical Interests

  • Clinical pathology
  • Transfusion medicine and apheresis

Selected Publications

Zheng W, O'Hear CE, Alli R, Basham JH, Abdelsamed HA, Palmer LE, Jones LL, Youngblood B, Geiger TL. PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells. Leukemia 32(5):1157-1167, 2018.

Sharma A, Geiger TL, Federico S, Kamens J, Giles F, Cunningham L. Hypocalcemic tetany after transfusion of a small amount of blood product. J Pediatr Hematol Oncol 39(8):629-932, 2017.

Chang TC, Carter RA, Li Y, Li Y, Wang H, Edmonson MN, Chen X, Arnold P, Geiger TL, Wu G, Peng J, Dyer M, Downing JR, Green DR, Thomas PG, Zhang J. The neoepitope landscape in pediatric cancers. Genome Med 9(1):78, 2017.

Zhao Y, Nguyen P, Ma J, Wu T, Jones LL, Pei D, Cheng C, Geiger TL. Preferential use of public TCR during autoimmune encephalomyelitis. J Immunol 196(12):4905-4914, 2016.

Ray A, Basu S, Gharaibeh RZ, Cook LC, Kumar R, Lefkowitz EJ, Walker CR, Morrow CD, Franklin CL, Geiger TL, Salzman NH, Fodor A, Dittel BN. Gut microbial dysbiosis due to Helicobacter drives an increase in marginal zone B cells in the absence of IL-10 signaling in macrophages. J Immunol 195(7):3071-3085, 2015.

Geiger TL, Rubnitz JE.  New approaches for the immunotherapy of acute myeloid leukemia. Discov Med 19(105):275-284, 2015.

O'Hear C, Heiber JF, Schubert I, Fey G, Geiger TL. Anti-CD33 chimeric antigen receptor targeting of acute myeloid leukemia. Haematologica 100(3):336-344, 2015.

Li B, Gurung P, Malireddi RK, Vogel P, Kanneganti TD, Geiger TL. IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis. Nat Commun  6:6131, 2015.Jones LL, Alli R, Li B, Geiger TL.  Differential T cell cytokine receptivity and not signal quality distinguishes IL-6 and IL-10 signaling during Th17 differentiation. The Journal of Immunology 196: 2973-85, 2016. PMID: 26912317

Geiger TL, Rubnitz J. New approaches for the immunotherapy of acute myeloid leukemia. Discovery Medicine. 19:275-84, 2015.

Gurung P, Li B, Subbarao Malireddi RK, Lamkanfi M, Geiger TL, Kanneganti TD. Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation. Nature Scientific Reports 5:14488, 2015. PMID: 26412089

Ray A, Basu S, Gharaibeh RZ, Cook LC, Kumar R, Lefkowitz EJ, Walker CR, Morrow CD, Franklin CL, Geiger TL, Salzman N, Fodor AA, Dittel BN. Gut Microbial Dysbiosis Due to Helicobacter Drives Marginal Zone B Cell Development in the Absence of IL-10 Signaling in Macrophages. The Journal of Immunology 195: 3071-85, 2015. PMID 26324769

O’Hear C, Heiber JF, Schubert I, Fey G, Geiger TL. Anti-CD33 chimeric antigen receptor targeting of acute myeloid leukemia. Haematologica 100:336-344, 2015. PMID: 25480499

Li B, Gurung P, Subbarao-Malireddi RK, Vogel P, Kanneganti TD, Geiger TL. IL-10 engages macrophages to induce an IL-1 to IL-6 shift in Th17 cytokine dependency and pathogenicity during T cell-mediated colitis. Nature Communications 6:6131-6144, 2015. PMID: 25607885

Lucca LE, Desbois S, Ramadan A, Ben-Nun A, Eisenstein M, Carrie N, Guery JC, Sette A, Nguyen P, Geiger TL, Mars LT, Liblau RS. Bispecificity for myelin and neuronal self-antigens is a common feature of CD4 T cells in C57BL/6 mice. J Immunol 193(7):3267-3277, 2014.

Li B, Alli R, Vogel P, Geiger TL. IL-10 modulates DSS-induced colitis through a macrophage-ROS-NO axis. Mucosal Immunol 7(4):869-878, 2014.

Tauro S, Nguyen P, Li B, Geiger TL. Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis. Eur J Immunol, 43(5):1195-1207, 2013.

Heiber JF, Geiger TL. Context and location dependence of adaptive Foxp3(+) regulatory T cell formation during immunopathological conditions. Cell Immunol 279(1):60-65, 2012.

Liu X, Alli R, Steeves M, Nguyen P, Vogel P, Geiger TL. The T cell response to IL-10 alters cellular dynamics and paradoxically promotes central nervous system autoimmunity. J Immunol 189(2):669-678, 2012.

Rujkijyanont P, Hipps J, Gan K, Yang J, Wang C, Geiger TL, Eldridge PW, Leung W. Prediction of CD34(+) cell yield in hematopoietic cell products from children by peripheral blood CD34(+) cell counts. Cytotherapy 14(4):473-482, 2012.

Geiger TL, Tauro S. Nature and nurture in Foxp3(+) regulatory T cell development, stability, and function. Hum Immunol 73(3):232-239, 2012.

Alli R, Nguyen P, Boyd K, Sundberg JP, Geiger TL. A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. J Immunol 188(1):477-86, 2012.

Alli R, Nguyen P, Geiger TL. Altered differentiation, diminished pathogenicity, and regulatory activity of myelin-specific T cells expressing an enhanced affinity TCR. J Immunol 187(11):5521-31, 2011.

Nguyen P, Ma J, Pei D, Obert C, Cheng C, Geiger TL. Identification of errors introduced during high throughput sequencing of the T cell receptor repertoire. BMC Genomics 12(106):1-13, 2011.

Alli R, Zhang ZM, Nguyen P, Zheng JJ, Geiger TL. Rational design of T cell receptors with enhanced sensitivity for antigen. PLoS One 6(3):18027, 2011.

Nguyen P, Liu W, Ma J, Manirarora JN, Liu X, Cheng C, Geiger TL. Discrete TCR repertoires and CDR3 features distinguish effector and Foxp3(+) regulatory T lymphocytes in myelin oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis. J Immunol 185(7):3895-904, 2010.

Nguyen P, Geiger TL. Induction of B cell immune tolerance by antigen-modified cytotoxic T lymphocytes. Transplantation 89: 667-676, 2010.

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Liu X, Nguyen P, Liu W, Cheng C, Steeves M, Obenauer JC, Ma J, Geiger TL. T cell receptor CDR3 sequence but not autoantigen recognition characteristics distinguish autoreactive effector and Foxp3+ regulatory T cells. Immunity 31: 909-920, 2009. 

Udyavar A, Alli R, Nguyen P, Baker L, Geiger TL. Subtle affinity enhancing mutations in a MOG-specific TCR revise specificity and generate new self-reactivity. J Immunol 182: 4439-4447, 2009.

Alli R, Nguyen P, Geiger TL. Retrogenic modeling of experimental allergic encephalomyelitis associates T-cell frequency but not T-cell receptor functional affinity with pathogenicity. J Immunol 181: 136-145, 2008.

Inaba H, Fan Y, Pounds S, Geiger TL, Rubnitz JE, Ribeiro RC, Pui CH, Razzouk B. Clinical and biological features and treatment outcome of children with newly diagnosed acute myeloid leukemia and hyperleukocytosis. Cancer 113: 522-529, 2008.

Inaba H, Steeves M, Nguyen P, Geiger TL. In vivo suppression of naïve CD4 T-cell responses by IL-2 and antigen stimulated T-lymphocytes in the absence of APC competition. J Immunol 181: 3323-3335, 2008.

Selvaraj R, Geiger TL. Mitigation of experimental allergic encephalomyelitis by TGF-β induced, Foxp3+ regulatory T-lymphocytes through the induction of anergy and infectious tolerance. J Immunol 180: 2830-2838, 2008.

Moisini I, Nguyen P, Fugger L, Geiger TL.  A humanized myelin basic protein-HLA-DR2-CD28-ζ chimeric receptor re-directs therapeutic T-cells against myelin-specific T-lymphocytes and blocks EAE. J Immunol 180: 3601-3611, 2008.

Nguyen P, Duthoit CT, Geiger TL.  Induction of tolerance and immunity by re-directed B-cell-specific cytolytic T-lymphocytes.  Gene Therapy 14: 1739-49, 2007.

Chaleff S, Otto M, Barfield RC, Leimig T, Iyengar R, Martin J, Holiday M, Houston J, Geiger T, Huppert V, Handgretinger R.  A large scale method for the selective depletion of αβ T-lymphocytes from PBSC for allogeneic transplantation. Cytotherapy 9: 746-754, 2007.

Selvaraj R, Geiger TL. A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-β. J Immunol 178: 7667-7677, 2007. (re-published 179: 1390-1401, 2007 due to publisher errors).

Peng J, Dicker B, Du W, Tang F, Nguyen P, Geiger T, Wong S, Wen L. Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction. J Autoimmunity 28: 188-200, 2007.

Sanders RP, Geiger TL, Heddle N, Pui CH, Howard SC.  A Revised Classification Scheme for Acute Transfusion Reactions. Transfusion 46: 621-628, 2007.

Wang Y, Liu Y, Wu C, Zhang H, Zheng X, Zheng Z, Geiger TL, Nuovo GJ, Liu Y, Zheng P. Epm2a suppresses tumor growth in the immune compromised host by inhibiting Wnt signaling. Cancer Cell 10: 179-190, 2006.

Inaba H, Geiger TL.  Defective cell cycle induction by IL-2 in naïve T-cells antigen-stimulated in the presence of refractory T-lymphocytes. Intl Immunol 18: 1043-1054, 2006.

Sanders RP, Maddirala SD, Geiger TL, Pounds S, Sandlund JT, Ribeiro RC, Pui CH, Howard SC. Premedication with acetaminophen or diphenhydramine does not affect the risk of febrile nonhemolytic or allergic transfusion reactions in pediatric hematology, oncology, and stem cell transplantation patients. Br J Haematol 130: 781-787, 2005.

Mekala DJ, Alli R, Geiger TL. Induction of infectious tolerance and IL-10-secreting regulatory T-cells by redirected CD4+CD25+ T-lymphocytes. Proc Natl Acad Sci USA 102: 11817-11822, 2005.

Duthoit CT, Mekala DJ, Alli R, Nguyen P, Geiger TL. Uncoupling of IL-2 signaling from cell-cycle progression in naïve CD4+ T-cells by regulatory CD4+CD25+ T-cells. J Immunol 174: 155-163, 2005.

Mekala DJ, Alli R, Geiger TL. IL-10 dependent treatment of EAE by the antigen-specific re-direction of Th2 T-lymphocytes against MBP-specific autoreactive T-cells. J Immunol 174: 3789-3797, 2005.

Lowe EJ, Pui CH, Hancock ML, Geiger TL, Khan RB, Sandlund JT. Early Complications in Children with Acute Lymphoblastic Leukemia Presenting with Hyperleukocytosis. Ped Blood and Cancer 44: 1-6, 2005.

Mekala DJ, Geiger TL. Immunotherapy of autoimmune encephalomyelitis with re-directed CD4+CD25+ T-lymphocytes. Blood 105: 2090-2092, 2005.

Inaba H, Geiger TL, Lasseter OE, Wang WC. A case of hemoglobin SC disease with cold agglutinin-induced hemolysis. American J Hematol 78: 37-40, 2005.

Last update: August 2018