Terrence Geiger, MD, PhD
Terrence L. Geiger, MD, PhD

Terrence L. Geiger, MD, PhD

Member, St. Jude Faculty

  • Senior Vice President and Deputy Director for Academic and Biomedical Operations
  • St. Jude Endowed Chair in Pediatrics

Departments

Education

MD – Yale University (1993)
PhD – Yale University (1993)

Research Interests

  • Immune regulation
  • Autoimmunity
  • Cellular immunotherapy

Clinical Interests

  • Clinical pathology
  • Transfusion medicine and apheresis

Selected Publications

Wei J, Long L, Zheng W, Dhungana Y, Lim SA, Guy C, Wang Y, Wang YD, Qian C, Xu B, Kc A, Saravia J, Huang H, Yu J, Doench JG, Geiger TL, Chi H. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature; Dec 2019;576(7787):471-476. doi: 10.1038/s41586-019-1821-z. Epub Dec 11, 2019. PMID: 31827283

Koelink PJ, Bloemendaal FM, Li B, Westera L, Vogels EWM, van Roest M, Gloudemans AK, van 't Wout AB, Korf H, Vermeire S, Te Velde AA, Ponsioen CY, D'Haens GR, Verbeek JS, Geiger TL, Wildenberg ME, van den Brink GR. Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling. Gut; Jun 2020;69(6):1053-1063. doi: 10.1136/gutjnl-2019-318264. Epub Sep 10, 2019.  PMID: 31506328

Zamora AE, Crawford JC, Allen EK, Guo XJ, Bakke J, Carter RA, Abdelsamed H, Moustaki A, Li Y, Chang TC, Awad W, Dallas MH, Mullighan CG, Downing JR, Geiger TL, Chen T, Green DR, Youngblood BA, Zhang J, Thomas PG. Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8(+) T cell responses. Sci Transl Med; Jun 26, 2019;11(498):eaat8549. doi: 10.1126/scitranslmed.aat8549. PMID: 31243155

Zheng W, Jones LL, Geiger TL. Modulation of PI3K signaling to improve CAR T cell function. Oncotarget; Nov 9, 2018;9(88):35807-35808. doi: 10.18632/oncotarget.26334. PMID: 30533195

Li B, Jones LL, Geiger TL. IL-6 promotes T cell proliferation and expansion under inflammatory conditions in association with low-level RORt expression. J Immunol; Nov 15, 2018;201(10):2934-2946. doi: 10.4049/jimmunol.1800016. Epub Oct 12, 2018.Zheng W, O’Hear CE, Alli R, Basham JH, Abdelsamed HA, Palmer LE, Jones LL, Youngblood B, Geiger TL. PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells. Leukemia 32:1157-67, 2018. PMID: 29479065.

Sharma A, Geiger TL, Federico S, Kamens J, Giles F, Cunningham L. Hypocalcemic tetany after transfusion of a small amount of blood product. J Pediatr Hematol Oncol 39(8):629-32, 2017. PMID: 2892075

Chang TC, Carter RA, Li Y, Li Y, Edmonson M, Chen X, Turner V, Geiger TL, Arnold P, Peng J, Dyer M, Green DR, Thomas PG, Zhang J. The neoepitope landscape in pediatric cancers.  Genome Medicine. 9: 78, 2017. PMID: 28854978.

Zhao Y, Nguyen P, Li B, Jones LL, Geiger TL. Autoimmune susceptibility imposed by public TCRb chains.  Nature Scientific Reports 6:37543, 2016.  PMID27869234.

Zhao Y, Nguyen P, Ma J, Wu T, Jones LL, Pei D, Cheng C, Geiger TL. Preferential use of public TCR during autoimmune encephalomyelitis. The Journal of Immunology 196:4905-14, 2016.  PMID: 27382130.

Jones LL, Alli R, Li B, Geiger TL. Differential T cell cytokine receptivity and not signal quality distinguishes IL-6 and IL-10 signaling during Th17 differentiation. The Journal of Immunology 196:2973-85, 2016. PMID: 26912317.

Gurung P, Li B, Subbarao Malireddi RK, Lamkanfi M, Geiger TL, Kanneganti TD. Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation. Nature Scientific Reports 5:14488, 2015. PMID: 26412089.

Ray A, Basu S, Gharaibeh RZ, Cook LC, Kumar R, Lefkowitz EJ, Walker CR, Morrow CD, Franklin CL, Geiger TL, Salzman N, Fodor AA, Dittel BN. Gut Microbial Dysbiosis Due to Helicobacter Drives Marginal Zone B Cell Development in the Absence of IL-10 Signaling in Macrophages. The Journal of Immunology 195:3071-85, 2015. PMID 26324769.

O’Hear C, Heiber JF, Schubert I, Fey G, Geiger TL. Anti-CD33 chimeric antigen receptor targeting of acute myeloid leukemia. Haematologica 100:336-344, 2015. PMID: 25480499.

Li B, Gurung P, Subbarao-Malireddi RK, Vogel P, Kanneganti TD,  Geiger TL. IL-10 engages macrophages to induce an IL-1 to IL-6 shift in Th17 cytokine dependency and pathogenicity during T cell-mediated colitis. Nature Communications 6:6131-6144, 2015. PMID: 25607885.

Geiger TL, Rubnitz J. New approaches for the immunotherapy of acute myeloid leukemia. Discovery Medicine 19:275-84, 2015.

Lucca LE, Desbois S, Ramadan A, Carrié N, Guéry JC, Sette A, Geiger TL, Mars LT, Liblau RS. Bispecificity for Myelin and Neuronal Self-Antigens Is a Common Feature of CD4 T Cells in C57BL/6 Mice. The Journal of Immunology 193:3267-77, 2014. PMID: 25135834.

Li B, Alli R, Vogel P, Geiger TL. IL-10 modulates DSS colitis through a macrophage-ROS-NO axis. Mucosal Immunol 7:869-878, 2014. PMID: 24301657.

Tauro S, Nguyen P, Li B, Geiger TL. Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis. Eur J Immunol 43:1195-207, 2013.

Liu X, Alli R, Steeves M, Nguyen P, Vogel P, Geiger TL. The T cell response to IL10 alters cellular dynamics and paradoxically enhances CNS autoimmunity. J Immunol 189:669-678, 2012.

Alli R, Nguyen P, Boyd K, Sundberg JP, Geiger TL. A mouse model of CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. J Immunol 188:477-486, 2012.  (Cover article).

Alli R, Zhang ZM, Nguyen P, Zheng J, Geiger TL. Rational design of T cell receptors with enhanced sensitivity for antigen. PLoS One  6:e18027, 2011.

Last update: October 2020

For updates on COVID-19, please read.