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Damon Runyon launches new pediatric cancer fellowship in partnership with St. Jude Children’s Research Hospital
06/08/2023
$9 million initiative addresses shortage of top young scientists entering pediatric cancer research careers.
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St. Jude finds NLRP12 as a new drug target for infection, inflammation and hemolytic diseases
06/01/2023
NLRP12 bridges hemolysis, inflammation and multi-organ damage. Learn how this ‘on’ switch for innate immune cell death could be a drug target to prevent pathology.
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Genetic change increased bird flu severity during U.S. spread
05/30/2023
Find how H5N1 avian influenza viruses increased disease-causing abilities & gained the capability to enter mammalian brains as they spread west across North America.
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SWI/SNF complexes “bookmark” cell identity during division
05/24/2023
Read about how Scientists at St. Jude determined how the SWI/SNF chromatin remodeling complex helps cancer cells remember how to be cancerous after division.
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Epigenetic landscape modulates pioneer transcription factor binding
05/24/2023
St. Jude scientists are studying how pioneer transcription factors access tightly wound DNA. Learn about how their findings may impact therapeutic development.
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Capturing transporter structure paves the way for drug development
05/23/2023
Learn how St. Jude scientists captured six new structures of the Spns2 transporter, providing insights to aid therapeutic design for cancer and other diseases.
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St. Jude scientist M. Madan Babu elected to the Royal Society of London
05/10/2023
Director of the St. Jude Center of Excellence for Data-Driven Discovery named a fellow of the 360-year-old British scientific organization.
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St. Jude tool gets more out of multi-omics data
05/04/2023
NetBID2 finds hidden drivers by extracting more from multi-omics data. Learn how the computational tool can find druggable targets in cancer and other diseases.
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Study shines light on impact of environment on neurocognitive outcomes
04/28/2023
Find how the neighborhood economic hardship index predicts baseline and long-term outcomes in pediatric brain tumor patients treated with radiation therapy.
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Clinical trial improves neurocognitive outcomes for childhood craniopharyngioma
04/18/2023
Proton therapy for craniopharyngioma had better neurocognitive than & similar survival outcomes as historical photon therapy. Read the phase 2 clinical trial.
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Prime editing shows proof of concept for treating sickle cell disease
04/17/2023
Genomic prime editing, a new DNA-changing technology, fixed sickle cell disease mutations in patient cells. Learn how it could lead to cure for genetic anemias.
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St. Jude scientists to receive coveted awards at AACR annual meeting
04/11/2023
Two St. Jude investigators will receive awards at the 2023 AACR meeting. Learn about their careers & the science they & their St. Jude peers will be sharing.
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Combination therapy overcomes BET inhibitor resistance
04/10/2023
St. Jude scientists found that combination of BET and GSK3 inhibitors can overcome treatment resistance in a type of childhood leukemia. Read about the study.
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Healthy lifestyle associated with reduced mortality risk in childhood cancer survivors
04/05/2023
A report from the Childhood Cancer Survivor Study (CCSS) provides strong evidence of the importance of a healthy lifestyle for adults who were treated for cancer as children
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Humans vs. Bacteria: Differences in Ribosome Decoding Revealed
04/05/2023
St. Jude scientists found that human ribosomes decode mRNA slower but more accurately than bacteria. Read about the study’s implications for drug development.
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St. Jude tool targets cancer-causing fusions’ weak spot
04/05/2023
Learn how St. Jude research cataloguing the oncogenic fusions in pediatric acute myeloid leukemia (AML) could lead to cures using genome editing (CRISPR-Cas9).
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Greg Armstrong, M.D., MSCE, named Chair of the Department of Epidemiology and Cancer Control at St. Jude Children’s Research Hospital
04/04/2023
National leader in the field of childhood cancer survivorship will spearhead research and advancements.
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Method for improving seasonal flu vaccines also aids pandemic prediction
03/29/2023
Influenza (flu) vaccines and pandemic predictions can be improved; learn how St. Jude scientists found impactful hemagglutinin mutations contributing to both.
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Integrated structural biology provides new clues for cystic fibrosis treatment
03/22/2023
Learn about how the cystic fibrosis transmembrane conductance regulator works and how findings from St. Jude will help therapeutic development.
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Kevin Krull, Ph.D., promoted to chair of the Department of Psychology and Biobehavioral Sciences
02/28/2023
The renamed department will investigate the biological mechanisms underlying the effects of catastrophic disease on the brain.
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St. Jude approach prevents drug resistance and toxicity
02/27/2023
Explore how St. Jude scientists overcame drug resistance and drug toxicity, using X-ray crystallography to avoid the detoxification pregnane X receptor (PXR).
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Octavio Ramilo, M.D., named chair of the Department of Infectious Diseases at St. Jude Children’s Research Hospital
02/16/2023
Internationally renowned expert will focus on growing St. Jude into a global leader in infectious diseases research.
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St. Jude expands patient education resource on childhood cancer
02/15/2023
This free online resource of information and education for families facing childhood and adolescent cancer has a truly global reach.
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A molecular ticket to ride: St. Jude scientists capture the cellular train that enables transport in cilia
02/13/2023
Find out how Scientists at St. Jude solved the 3D structure of a cellular train in cilia, IFT-A, at nearly ten times the resolution of previous efforts.
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Access matters: lack of resources is associated with increased mortality in childhood cancer survivors
02/10/2023
Find how increased mortality in childhood cancer survivors is independently associated with local resource deprivation and certain chronic health conditions.
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Detect minor clones in blood cells: St. Jude looks deep to find source of accelerated aging in childhood cancer survivors
02/08/2023
Explore how deep sequencing childhood cancer survivors found the mutational fingerprint of a toxic chemotherapy associated with a marker of accelerated aging.
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St. Jude scientists create more efficient CAR immunotherapies using a molecular anchor
02/02/2023
Discover how chimeric antigen receptors (CARs) with a new anchor domain increased anti-cancer activity of cellular immunotherapies in cancer models.
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Thirumala-Devi Kanneganti, Ph.D. named 2022 AAAS Fellow
01/31/2023
Immunologist recognized for her achievements in innate immunity, developing new concepts in inflammasome biology, inflammatory cell death.
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Catherine Corbin named chief business innovation officer at St. Jude
01/30/2023
Expert in human-centered design to lead new St. Jude department focused on advancing strategic plan.
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St. Jude names leading researcher as new chair of oncology department
01/26/2023
Julie R. Park, M.D., to succeed longtime chair Ching-Hon Pui, M.D.
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Pioneering approach advances study of CTCF protein in transcription biology
01/25/2023
Scientists at St. Jude used an innovative degradation system on CTCF, learning more about this protein’s role in transcription. Read about the findings.
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St. Jude Children’s Research Hospital unveils 45,000-square-foot Family Commons
01/23/2023
Made possible by a $50 million donation from AbbVie, Family Commons is a space for patients and their families to relax and gather in between clinic appointments.
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Structural insights reveal how SPOP protein contributes to cancer
01/23/2023
St. Jude scientists have captured the 3D structure of the SPOP protein, revealing how it contributes to cancer. Read about the implications for therapeutics.
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Pharmacotyping of childhood leukemia provides a blueprint for ‘true precision medicine’
01/05/2023
St. Jude scientists performed the largest study yet examining drug sensitivity in childhood acute lymphoblastic leukemia across genomic subtypes and its association with treatment response.