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Caitlin Zebley, MD, PhD
Caitlin Zebley, MD, PhD

Caitlin Zebley, MD, PhD

Instructor, St. Jude Faculty



BS (Chemistry, Biology) - Iona College, New Rochelle, NY
MD - Chicago Medical School, North Chicago, IL
Pediatric Residency - University of Minnesota, Minneapolis, MN
Pediatric Hematology/Oncology Fellowship - St. Jude Children’s Research Hospital, Memphis, TN
PhD - St. Jude Graduate School of Biomedical Sciences, Memphis, TN

Research Interests

  • Fundamental mechanisms of T cell biology

Selected Publications

Zebley CC, Gottschalk S, Youngblood B. Rewriting history: Epigenetic reprogramming of CD8+ T cell differentiation to enhance immunotherapy. Trends in Immunology 2020.

Abdelsamed HA*, Zebley CC*, Nguyen H*, Rutishauser RL, Fan Y, Ghoneim H, Crawford JC, Alfei F, Alli S, Ribeiro, SP, Serti E, Castellaw A, McGargill MA, Jin H, Boi SK, Serti E, Turka LA, Busch ME, Stone M, Deeks SG, Sekaly RP, Zehn D, James E, Nepom GT, Youngblood B. Human self-reactive CD8 T cells acquire stem-cell memory-associated epigenetic programs during development of type 1 diabetes. Nature Immunology 21:578-587, 2020.

Fonseca R, Beura LK, Quarnstrom CF, Ghoneim HE, Fan Y, Zebley CC, Scott MC, Fares-Frederickson NJ, Wijeyesinghe S, Thompson EA, da Silva HB, Vezys V, Youngblood B, Masopust D. Developmental plasticity allows outside-in immune responses by resident memory T cells. Nature Immunology 21:412-421, 2020.

Abdesladmed HA, Zebley CC, Youngblood B. Epigenetic maintenance of acquired gene expression programs during memory CD8 T cell homeostasis. Frontiers in Immunology 9:6, 2018.

Abdelsamed HA, Zebley CC, Youngblood B. In vitro Homeostatic Proliferation of Human CD8 T Cells. Bio-protocol 7(22), 2017.

Abdelsamed HA, Moustaki A, Fan Y, Dogra P, Ghoneim HE, Zebley CC, Triplett BM, Sekaly RP, Youngblood B. Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis. Journal of Experimental Medicine 214(6):1593-1606, 2017

Last update: December 2020