Selected Publications
Zebley CC, Brown C, Mi T, Fan Y, Alli S, Boi S, Galletti G, Lugli E, Langfitt D, Metais J-Y, Lockey T, Meagher M, Triplett B, Talleur AC, Gottschalk S, Youngblood B. CD19-CAR T cells undergo exhaustion DNA methylation programming in patients with acute lymphoblastic leukemia. Cell Rep Nov 30;37(9):110079, 2021. doi: 10.1016/j.celrep.2021.110079. PMID: 34852226
Prinzing B, Zebley CC, Petersen CT, Fan Y, Anido AA, Yi Z, Nguyen P, Houke H, Bell M, Haydar D, Brown C, Boi SK, Alli S, Crawford JC, Riberdy JM, Park JJ, Zhou S, Velasquez MP, DeRenzo C, Lazzarotto CR, Tsai SQ, Vogel P, Pruett-Miller SM, Langfitt DM, Gottschalk S, Youngblood B, Krenciute G. Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity. Sci Transl Med Nov 17;13(620):eabh0272, 2021. doi: 10.1126/scitranslmed.abh0272. Epub 2021 Nov 17. PMID: 34788079
Zebley CC, Abdelsamed HA, Ghoneim HE, Alli S, Brown C, Haydar D, Mi T, Harris T, McGargill MA, Krenciute G, Youngblood B. Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation. Cell Rep Oct 12;37(2):109796, 2021. doi: 10.1016/j.celrep.2021.109796. PMID: 34644568
Zebley CC, Gottschalk S, Youngblood B. Rewriting history: Epigenetic reprogramming of CD8+ T cell differentiation to enhance immunotherapy. Trends in Immunology 2020.
Abdelsamed HA*, Zebley CC*, Nguyen H*, Rutishauser RL, Fan Y, Ghoneim H, Crawford JC, Alfei F, Alli S, Ribeiro, SP, Serti E, Castellaw A, McGargill MA, Jin H, Boi SK, Serti E, Turka LA, Busch ME, Stone M, Deeks SG, Sekaly RP, Zehn D, James E, Nepom GT, Youngblood B. Human self-reactive CD8 T cells acquire stem-cell memory-associated epigenetic programs during development of type 1 diabetes. Nature Immunology 21:578-587, 2020.
Fonseca R, Beura LK, Quarnstrom CF, Ghoneim HE, Fan Y, Zebley CC, Scott MC, Fares-Frederickson NJ, Wijeyesinghe S, Thompson EA, da Silva HB, Vezys V, Youngblood B, Masopust D. Developmental plasticity allows outside-in immune responses by resident memory T cells. Nature Immunology 21:412-421, 2020.
Abdesladmed HA, Zebley CC, Youngblood B. Epigenetic maintenance of acquired gene expression programs during memory CD8 T cell homeostasis. Frontiers in Immunology 9:6, 2018.
Abdelsamed HA, Zebley CC, Youngblood B. In vitro Homeostatic Proliferation of Human CD8 T Cells. Bio-protocol 7(22), 2017.
Abdelsamed HA, Moustaki A, Fan Y, Dogra P, Ghoneim HE, Zebley CC, Triplett BM, Sekaly RP, Youngblood B. Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis. Journal of Experimental Medicine 214(6):1593-1606, 2017
Last update: January 2022