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Liqin Zhu, PhD
Liqin Zhu, PhD


PhD – Purdue University, West Lafayette, Indiana

Research Interests

  • Mouse model of childhood hepatoblastoma
  • Stem cell in normal tissue development
  • Cell-of-origin of pediatric vs. adult cancers 

Selected Publications

Li L, Qian M, Chen IH, Finkelstein D, Onar-Thomas A, Johnson M, Calabrese C, Bahrami A, López-Terrada DH, Yang JJ, Tao WA, Zhu L. Acquisition of Cholangiocarcinoma Traits during Advanced Hepatocellular Carcinoma Development in Mice. Am J Pathol 188(3):656-671, 2018.

Cast A, Valanejad L, Wright M, Nguyen P, Gupta A, Zhu L, Shin S, Timchenko N. C/EBPα-dependent pre-neoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive pediatric liver cancer. Hepatology 2018

Zhu L, Finkelstein D, Gao C, Shi L, Wang Y, López-Terrada D, Wang K, Utley S, Pounds S, Neale G, Ellison D, Onar-Thomas A, Gilbertson RJ. Multi-organ mapping of cancer risk. Cell 166(5):1132-46, 2016.

Man SM*, Zhu Q*, Zhu L*, Liu Z*, Karki R, Malik A, Sharma D, Li L, Malireddi DKS, Gurung P, Neale G, Olsen SR, Carter RA, McGoldrick DJ, Wu G, Finkelstein D, Vogel P, Gilbertson RJ, and Kanneganti T. Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer. *Equal contribution. Cell 162(1):45-58, 2015.

Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM, Féau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WK, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ. An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma.Cancer Cell 20(3):384-99, 2011.

Shi G*, Zhu L*, Sun Y, Bettencourt R, Damsz B, Hruban RH, Konieczny SF. Loss of the acinar-restricted transcription factor Mist1accelerates Kras-induced pancreatic intraepithelial neoplasia, Gastroenterology 136(4):1368-1378, 2009. *Equal contribution.

Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, Poppleton H, Zakharenko S, Ellison DW, Gilbertson RJ. Prominin1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 457(7229):603-607, 2009.

Zhu L, Shi G, Schmidt CM, Hruban RH, Konieczny SF. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol 171(1):263-273, 2007.

Tuveson DA, Zhu L, Gopinathan A, Willis NA, Kachatrian L, Grochow R, Pin CL, Mitin NY, Taparowsky EJ, Gimotty PA, Hruban RH, Jacks T, Konieczny SF. Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreas carcinoma. Cancer Res 66(1):242-247, 2006.

Zhu L, Tran T, Rukstalis JM, Sun P, Damsz B, Konieczny SF. Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia. Mol Cell Biol 24:2673-2681, 2004.

Geng C, Pellegrino A, Bowman J, Zhu L, Pak WL. Complete RNAi rescue of neuronal degeneration in a constitutively active drosophila TRP channel mutant. Biochim Biophys Acta 1674:91-97, 2004.

Rukstalis JM, Kowalik A, Zhu L, Lidington D, Pin CL. Konieczny SF. Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1. J Cell Sci 116:3315-3325, 2003.

Xiao S, Bu L, Zhu L, Zheng G, Yang M, Qian M, Hu L, Liu J, Zhao G, Kong X. A new locus for hereditary gingival fibromatosis (GINGF2) maps to 5q13-q22. Genomics 74:180-185, 2001.

Xiao S, Wang X, Qu B, Yang M, Liu G, Bu L, Wang Y, Zhu L, Lei H, Hu L, Zhang X, Liu J, Zhao G, Kong X. Refinement of the locus for autosomal dominant hereditary gingival fibromatosis (GINGF) to a 3.8-cM region on 2p21. Genomics 68:247-252, 2000.

Last update: October 2019