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Lindsay Schwarz, PhD
Lindsay Schwarz, PhD


Postdoctoral – Stanford University/HHMI, Stanford, California
PhD – University of California, San Diego, La Jolla, California
BS – University of Washington, Seattle, Washington

Honors & Awards

  • 2022  Neurobiology of Brain Disorders Award, McKnight Endowment Fund for Neuroscience
  • 2019 Hartwell Individual Biomedical Research Award
  • 2019  NARSAD Young Investigator Award
  • 2019  NIH Director’s New Innovator Award
  • 2018  Rita Allen Foundation Scholar

Research Interests

  • Mechanisms regulating diverse functions of neuromodulatory circuits
  • Activity patterns of neuromodulatory neurons in vivo during arousal-related behaviors
  • Molecular diversity of locus coeruleus neurons
  • How changes in neuromodulatory circuits promote psychiatric and neurodegenerative disorders

Read about my lab >

Selected Publications

Contreras X, Amberg N, Davaatseren A, Hansen AH, Sonntag J, Andersen L, Bernthaler T, Streicher C, Heger A, Johnson RL, Schwarz LA, Luo L, Rülicke T,  Hippenmeyer S. A genome-wide library of MADM mice for single-cell genetic mosaic analysis. Cell Rep Jan22;35(12), 2021.

Li P, Shi-Bin Li B, Wang X, D Phillips CD, Schwarz LA, Luo L, de Lecea L, Krasnow MA. Brain Circuit of Claustrophobia-like Behavior in Mice Identified by Upstream Tracing of Sighing. Cell Rep Jun 16;31(11):107779, 2020. 

Chandler DJ, Jensen P, McCall JG, Pickering AE, Schwarz LA, Totah NK. Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture. J Neurosci Oct 16;39(42):8239-8249, 2019.

Yackle K, Schwarz LA, Kam K, Sorokin JM, Huguenard JR, Feldman JL, Luo L, Krasnow MA. Breathing control center neurons that promote arousal in mice. Science 355(6332):1411-15, 2017.

Huang WH, Guenthner CJ, Xu J, Nguyen T, Schwarz LA, Wilkinson AW, Gozani O, Chang HY, Shamloo M, Luo L. Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome. Neuron 92(2):392-406, 2016.

Gong H, Xu D, Yuan J, Li X, Guo C, Peng J, Li Y, Schwarz LA, Li A, Hu B, Xiong B, Sun Q, Zhang Y, Liu J, Zhong Q, Xu T, Zeng S, Luo Q. High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level. Nat Commun 4(7):12142, 2016.

Beier KT, Steinberg EE, DeLoach KE, Xie S, Miyamichi KM, Schwarz LA, Gao XJ, Kremer EJ, Malenka RC, Luo L. Circuit architecture of VTA dopamine neurons revealed by systematic input–output mapping. Cell 162(3):622-34, 2015.

Schwarz LA*, Miyamichi KM*, Gao XJ, Beier KT, Weissbourd B, DeLoach KE, Ren J, Ibanes S, Malenka RC, Kramer EJ, Luo L. Viral-genetic tracing of the input-output organization of a central norepinephrine circuit. Nature 524(7563):88-92, 2015. *equal contribution

Schwarz LA, Luo L. Organization of the Locus Coeruleus Norepinephrine System. Current Biology 25(21):1051-56, 2015.

Scudder SL, Goo MS, Cartier AE, Molteni A, Schwarz LA, Wright R, Patrick GN. Synaptic Strength is Bidirectionally Controlled by Opposing Activity-Dependent Regulation of Nedd4-1 and USP8. J Neurosci 34(50):16637-49, 2014.

Schwarz LA, Patrick GN. Role of Ubiquitination in Regulating the Endocytosis and Intercellular Trafficking of Surface Proteins in the Nervous System. Mol Cell Neurosci 49(3):387-93, 2011.

Schwarz LA, Hall BJ, Patrick GN. Activity-Dependent Ubiquitination of GluA1 Mediates a Distinct AMPAR Endocytosis and Sorting Pathway. J Neurosci 30(49):16718-29, 2010.

Last update: June 2021