Lindsay Schwarz, PhD
Lindsay Schwarz, PhD

Lindsay Schwarz, PhD

Assistant Member, St. Jude Faculty

Departments

Research Interests

  • Mechanisms regulating diverse functions of neuromodulatory circuits
  • Activity patterns of neuromodulatory neurons in vivo during arousal-related behaviors
  • Molecular diversity of locus coeruleus neurons
  • How changes in neuromodulatory circuits promote psychiatric and neurodegenerative disorders

Read about my lab >

Selected Publications

Yackle K, Schwarz LA, Kam K, Sorokin JM, Huguenard JR, Feldman JL, Luo L, Krasnow MA. Breathing control center neurons that promote arousal in mice. Science 2017 (in press).

Huang WH, Guenthner CJ, Xu J, Nguyen T, Schwarz LA, Wilkinson AW, Gozani O, Chang HY, Shamloo M, Luo L. Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome. Neuron 92(2):392-406, 2016.

Gong H, Xu D, Yuan J, Li X, Guo C, Peng J, Li Y, Schwarz LA, Li A, Hu B, Xiong B, Sun Q, Zhang Y, Liu J, Zhong Q, Xu T, Zeng S, Luo Q. High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level. Nat Commun 4(7):12142, 2016.

Beier KT, Steinberg EE, DeLoach KE, Xie S, Miyamichi KM, Schwarz LA, Gao XJ, Kremer EJ, Malenka RC, Luo L. Circuit architecture of VTA dopamine neurons revealed by systematic input–output mapping. Cell 162(3):622-34, 2015.

Schwarz LA*, Miyamichi KM*, Gao XJ, Beier KT, Weissbourd B, DeLoach KE, Ren J, Ibanes S, Malenka RC, Kramer EJ, Luo L. Viral-genetic tracing of the input-output organization of a central norepinephrine circuit. Nature 524(7563):88-92, 2015. *equal contribution

Schwarz LA, Luo L. Organization of the Locus Coeruleus Norepinephrine System. Current Biology 25(21):1051-56, 2015.

Scudder SL, Goo MS, Cartier AE, Molteni A, Schwarz LA, Wright R, Patrick GN. Synaptic Strength is Bidirectionally Controlled by Opposing Activity-Dependent Regulation of Nedd4-1 and USP8. J Neurosci 34(50):16637-49, 2014.

Schwarz LA, Patrick GN. Role of Ubiquitination in Regulating the Endocytosis and Intercellular Trafficking of Surface Proteins in the Nervous System. Mol Cell Neurosci 49(3):387-93, 2011.

Schwarz LA, Hall BJ, Patrick GN. Activity-Dependent Ubiquitination of GluA1 Mediates a Distinct AMPAR Endocytosis and Sorting Pathway. J Neurosci 30(49):16718-29, 2010.

Last update: March 2017