Departmental Focus

Scientists in the Department of Developmental Neurobiology investigate the fundamental processes that govern normal brain development and function. We believe that this information will provide unique opportunities for understanding and treating a range of diseases afflicting the nervous system including tumors, defects in hearing and vision as well as neurodegenerative and psychiatric disorders. Our goal to enhance novel clinical therapies is facilitated by fostering an interactive environment where researchers investigating fundamental aspects of nervous system development and function of neural circuits are juxtaposed to those engaged in clinical and translational research. Indeed, faculty in the department hold key leadership positions in two of the institutional Comprehensive Cancer Center Programs: the Neurobiology and Brain Tumor Program and the Developmental Biology and Solid Tumor Program; each recognized for its basic, translational and clinical research into tumors afflicting children. To further strengthen translational interactions and fundamental research, the department hosts two divisions, Brain Tumor Research and Neural Circuits and Behavior, whose research efforts are complimentalry to the goals of the CCC.

Current research includes studies of early cell fate decisions and control of brain growth, neuronal migration and synapse formation, analysis of the mechanisms responsible for synaptic plasticity, neural circuit function and animal behavior, investigations of the control of cell death and regeneration, examination of mechanisms in neurodegenerative diseases, identification of genes involved in the formation and function of the retina, and elucidation of the molecular mechanisms underlying a range of tumors, including medulloblastoma, neuroblastoma, retinoblastoma, ependymoma and glioma. These investigations are further leveraged by our use of multiple experimental platforms that range from comprehensive genomics and proteomics to advanced cellular and in vivo imaging and computational biology to derivation of novel genetic preclinical models of childhood diseases.

Stanislav Zakharenko
Department of Development Neurobiology

Divisions

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Department of Developmental Neurobiology
MS 323
St. Jude Children Research Hospital

262 Danny Thomas Place
Memphis, TN, 38105-3678 USA
901-595-6195 michael.dyer@stjude.org
262 Danny Thomas Place
Memphis, TN, 38105-3678 USA
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