Friday, October 20, 2017
8:00 am – 5:30 pm
Marlo Thomas Center GECC
St. Jude Children's Research Hospital
Memphis, TN 38105
The role of RNA in human biology — both in health and in disease — has a history stretching back to the primordial soup. Compelling evidence suggests that RNAs served as proto-enzymes and proto-genes that helped lay the foundations for the origin of life. In recent years, as we have gained a better understanding of the structure and function of coding and non-coding RNAs, the appreciation for the broad influence of RNAs has only grown. In particular, improved knowledge of RNAs has provided fundamental insights into genetic and epigenetic underpinnings of human diseases, most notably neurological diseases and cancer, thereby suggesting and informing therapeutic approaches. The 13th Annual St. Jude Children’s Research Hospital Biomedical Symposium brings together leading experts in the fields of RNA processing, structure, function, epigenetics, and therapeutics. These topics are of direct relevance to our mission to better understand pediatric diseases and will be of great interest to both basic and translational investigators.
Member, St. Jude Faculty
- Chair, Cell & Molecular Biology Department
- Investigator, Howard Hughes Medical Institute
- Associate Director, Basic Research, Comprehensive Cancer Center
- Cell & Molecular Biology Department
- Comprehensive Cancer Center
- St. Jude Graduate School of Biomedical Sciences
David Bartel, PhD
Whitehead Institute, Massachusetts Institute of Technology and Howard Hughes Medical Institute
Joshua Mendell, MD, PhD
UT Southwestern Medical Center and Howard Hughes Medical Institute
Ron Breaker, PhD
Yale University and Howard Hughes Medical Institute
Kathrin Plath, PhD
University of California Los Angeles
Charles Gersbach, PhD
Frank Slack, PhD
BIDMC Cancer Center/Harvard Medical School
Adrian Krainer, PhD
Cold Spring Harbor Laboratory
Kevin Weeks, PhD
University of North Carolina at Chapel Hill
|8:00 – 8:30 a.m.||Registration, Coffee and Refreshments
|8:30 – 8:40 a.m.||Introduction – J. Paul Taylor, MD, PhD|
|8:40 – 9:30 a.m.||Adrian Krainer, PhD – Cold Spring Harbor Laboratory
"Targeted Antisene Therapy for Spinal Muscular Atrophy"
Host: Elizabeth Stewart
|9:30 – 10:20 a.m.||David Bartel, PhD – Whitehead Institute of Technology and Howard Hughes Medical Institute
"MicroRNAs and their Regulatory Effects"
Host: Shannon McKinney-Freeman, PhD
|10:20 – 10:35 a.m.||Coffee Break, Group Picture of Speakers|
|10:35 – 11:25 a.m.||Frank Slack, PhD – BIDMC Cancer Center/Harvard Medical School
"MicroRNA Based Therapy in Cancer"
Host: Benjamin A. Youngblood
|11:25 a.m. – 12:15 p.m.||Joshua Mendell, MD, PhD – UT Southwestern Medical Center and Howard Hughes Medical Institute
"Regulation and Function of Noncoding RNSs in Mammals"
Host: Mark E. Hatley, MD, PhD
|12:15 – 1:30 p.m.||Lunch (Speakers at assigned tables with trainees)|
|1:30 – 2:20 p.m.||Kevin Weeks, PhD – University of North Carolina, Chapel Hill
"Structure-Based Discovery of New Functions in Large RNAs"
Host: Malia B. Potts, PhD
|2:20 – 3:10 p.m.||Ronald Breaker, PhD – Yale University and Howard Hughes Medical Institute
Host: Tanja Mittag, PhD
|3:10 – 3:25 p.m.||Break|
|3:25 – 4:15 p.m.||Charles Gersbach, PhD – Duke University
"CRISPR-Based Genome and Epigenome Editing for Gene Therapy and Cell Programming"
Host: Shondra Pruett-Miller, PhD
|4:15 – 5:05 p.m.||Katherin Plath, PhD – University of California, Los Angeles
"The Many Faces of Xist"
Host: Hans-Martin Herz, PhD
|5:05 – 5:10 p.m.||Closing Remarks – Jamy Peng, PhD|
|6:00 p.m.||Symposium Celebration, Madison Hotel|