12th Annual Biomedical Research Symposium

Epigenetics in Development and Cancer


Friday, October 7, 2016
8:00 am – 5:30 pm
Marlo Thomas Center GECC
Room IA1011
St. Jude Children's Research Hospital
Memphis, TN 38105-3678

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Program Overview

There has been an explosion of interest in the field of epigenetic regulation of gene function, which is central both to normal cell development and cancer. Recent key advances include a deeper understanding of the range and type of histone modifications, the technical capability to examine chromatin marks with great resolution, insights into nature of epigenetic mutations in cancer, and the burgeoning promise of therapeutic approaches to exploit and target epigenetic perturbations in cancer. This 12th annual St Jude Children's Research Hospital Biomedical Symposium brings together leading experts in the field of epigenetics in development, cancer and clinical translation. The symposium will be of direct relevance to our understanding of childhood cancer and will be of great interest to both basic and translational investigators.

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Symposium Hosts


Robert A. Copeland, PhD
Epizyme Inc.

Mark A. Dawson, PhD
Peter MacCallum Cancer Centre

Andrew P. Feinberg, MD, MPH
Johns Hopkins University

Kristian Helin, PhD
Biotech Research & Innovation Centre, University of Copenhagen

Tony Kouzarides, FMedSci, FRS
The Gurdon Institute, University of Cambridge

Danny Reinberg, PhD
New York University School of Medicine

Ali Shilatifard, PhD
Northwestern University Feinberg School of Medicine

Richard A. Young, PhD
The Whitehead Institute, Massachusetts Institute of Technology


Time Event
8:00 – 8:30 am Registration, Coffee and Refreshments
Speakers report to Ready Room
8:30 – 8:40 am Introduction – Martine Roussel, PhD
8:40 – 9:30 am Histone Methylation in Transcription Regulation, Differentiation, & Cancer
Kristian Helin, PhD, Biotech Research & Innovation Centre, University of Copenhagen
Host: Ben Youngblood, PhD
9:30 – 10:20 am Epigenetics: One Genome, Multiple Phenotypes
Danny Reinberg, PhD, New York University School of Medicine  
Host: Shannon McKinney-Freeman, PhD
10:20 – 10:35 am Coffee Break, Group Picture of Speakers in the St. Jude Garden
10:35 – 11:25 am Epigenetic Modulators, Modifiers, and Mediators in Cancer Etiology and Progression
Andrew P. Feinberg, MD, MPH, Johns Hopkins University
Host: Janet Partridge, PhD
11:25 am – 12:15 pm Placing BETs on Hold in Acute Myeloid Leukaemia
Mark A. Dawson, PhD, Peter MacCallum Cancer Centre
Host: Charles Mullighan, MBBS, MD
12:15 – 1:30 pm Lunch – Pavilion (Speakers have assigned tables with Trainees)
1:30 – 2:20 pm Development and Disease: The View from Chromosome Neighborhoods
Richard A. Young, PhD, The Whitehead Institute, Massachusetts Institute of Technology  
Host:  Peter Murray, PhD
2:20 – 3:10 pm Epigenetic Modifications: Their Function and Role in Cancer
Tony Kouzarides, FMedSci, FRS, The Gurdon Institute, University of Cambridge
Host: Jamy Peng, PhD
3:10 – 3:25 pm Coffee Break
3:25 – 4:15 pm Principles of Epigenetics and Chromatin in Development and Human Disease
Ali Shilatifard, PhD, Northwestern University Feinberg School of Medicine
Host: Hanz-Martin Herz, PhD
4:15 – 5:05 pm Tazemetostat – A First-in-Class Inhibitor of EZH2
Robert A. Copeland, PhD, Epizyme Inc.
Host:  Jeffrey Klco, MD, PhD
5:05 – 5:10 pm Closing Remarks – Charles Mullighan, MBBS, MD
6:00 – 10:00 pm Symposium celebration and reception at the Madison Hotel


Register for the Conference

Upcoming Symposia


RNA Metabolism and Human Disease
Hosted by J. Paul Taylor, MD, PhD


Targeted Therapies in Cancer
Hosted by Charles J. Sherr, MD, PhD