13th Annual Biomedical Research Symposium

RNA Metabolism and Human Disease

 

Friday, October 20, 2017
8:00 am – 5:30 pm
Marlo Thomas Center GECC
Room IA-1011
St. Jude Children's Research Hospital
Memphis, TN 38105

Campus Map >

Program Overview

The role of RNA in human biology — both in health and in disease — has a history stretching back to the primordial soup. Compelling evidence suggests that RNAs served as proto-enzymes and proto-genes that helped lay the foundations for the origin of life. In recent years, as we have gained a better understanding of the structure and function of coding and non-coding RNAs, the appreciation for the broad influence of RNAs has only grown. In particular, improved knowledge of RNAs has provided fundamental insights into genetic and epigenetic underpinnings of human diseases, most notably neurological diseases and cancer, thereby suggesting and informing therapeutic approaches. The 13th Annual St. Jude Children’s Research Hospital Biomedical Symposium brings together leading experts in the fields of RNA processing, structure, function, epigenetics, and therapeutics. These topics are of direct relevance to our mission to better understand pediatric diseases and will be of great interest to both basic and translational investigators.

Symposium Hosts

Speakers

Dave Bartel, PhD

David Bartel, PhD
Whitehead Institute, Massachusetts Institute of Technology and Howard Hughes Medical Institute
Bartel Lab Web page >

Joshua Mendell, MD, PhD

Joshua Mendell, MD, PhD
UT Southwestern Medical Center and Howard Hughes Medical Institute
Mendell Lab Web page >

Ron Breaker, PhD

Ron Breaker, PhD
Yale University and Howard Hughes Medical Institute
Breaker Lab Web page >

Katherin Plath, PhD

Kathrin Plath, PhD
University of California Los Angeles
Plath Lab Web page >

Charles Gersbach, PhD

Charles Gersbach, PhD
Duke University
Gersbach Lab Web page >

Frank Slack, PhD

Frank Slack, PhD
BIDMC Cancer Center/Harvard Medical School
Slack Lab Web page >

Adrian Krainer, PhD

Adrian Krainer, PhD
Cold Spring Harbor Laboratory
Krainer Lab Web page >

Kevin Weeks, PhD

Kevin Weeks, PhD
University of North Carolina at Chapel Hill
Weeks Lab Web page >

Agenda

Time Event
8:00 – 8:30 a.m. Registration, Coffee and Refreshments
8:30 – 8:40 a.m. Introduction – J. Paul Taylor, MD, PhD
8:40 – 9:30 a.m. Adrian Krainer, PhD – Cold Spring Harbor Laboratory
"Targeted Antisense Therapy for Spinal Muscular Atrophy"
Host: Elizabeth Stewart, MD 
9:30 – 10:20 a.m. David Bartel, PhD – Whitehead Institute, Massachusetts Institute of Technology and Howard Hughes Medical Institute
"MicroRNAs and Other Regulatory RNAs"
Host: Shannon McKinney-Freeman, PhD
10:20 – 10:35 a.m. Coffee Break, Group Picture of Speakers
10:35 – 11:25 a.m. Frank Slack, PhD – BIDMC Cancer Center/Harvard Medical School
"MicroRNA Based Therapeutics in Cancer"
Host: Benjamin A. Youngblood
11:25 a.m. – 12:15 p.m. Joshua Mendell, MD, PhD – UT Southwestern Medical Center and Howard Hughes Medical Institute
"Regulation and Function of Noncoding RNAs in Mammals"
Host: Mark E. Hatley, MD, PhD
12:15 – 1:30 p.m. Lunch (Speakers at assigned tables with trainees)
1:30 – 2:20 p.m. Kevin Weeks, PhD – University of North Carolina, Chapel Hill
"Structure-Based Discovery of New Functions in Large RNAs"
Host: Malia B. Potts, PhD
2:20 – 3:10 p.m. Ronald Breaker, PhD – Yale University and Howard Hughes Medical Institute
"Gene Regulation by Riboswitches"
Host: Tanja Mittag, PhD
3:10 – 3:25 p.m. Break
3:25 – 4:15 p.m. Charles Gersbach, PhD – Duke University
"CRISPR-Based Genome and Epigenome Editing for Gene Therapy and Cell Programming"
Host: Shondra Pruett-Miller, PhD 
4:15 – 5:05 p.m. Katherin Plath, PhD – University of California, Los Angeles
"The Many Faces of Xist"
Host: Hans-Martin Herz, PhD
5:05 – 5:10 p.m. Closing Remarks – Jamy Peng, PhD
6:00 p.m. Symposium Celebration, Madison Hotel

Upcoming Symposia

2018

Targeted Therapies in Cancer
Hosts: Charles J. Sherr, MD, PhD, and Tanja Gruber, MD, PhD