St. Jude names Ellis Neufeld, M.D., Ph.D., clinical director and physician-in-chief
Esteemed hematologist will lead clinical efforts and related expansions to patient care programs
Mystery molecule is a key to inhibiting colon cancer
Mystery sensor protein NLRC3 revealed as a central player in preventing colon cells from becoming cancerous
Loss of ARID1A protein drives onset and progress of colon cancer
Research reveals principal tumor suppressor function of ARID1A and suggests that loss of the protein contributes to colon cancer
The latest advances in the study of blood diseases presented at annual meeting of ASH
St. Jude scientists and clinicians present research and thought leadership at the annual meeting of the American Society of Hematology in San Diego.
Small RNA identified that offers clues for quieting the “voices” of schizophrenia
Researchers identify a microRNA that may be key to restoring normal functioning of a brain circuit and quieting the “voices” of schizophrenia
Prevalence of Ph-like ALL in adults underscores need for genetic testing, clinical trials
Ph-like ALL accounts for significant percentage of acute lymphoblastic leukemia in adults, underscoring need for clinical trials of targeted
Potential targeted therapy found for newly identified leukemia subtype with poor outcome
The MEF2D-rearranged subtype of acute lymphoblastic leukemia (ALL) is linked to poor outcomes. Now a possible targeted therapy has been identified.
Childhood cancer survivors are living longer but do not report improvement in health status
Childhood Cancer Survivor Study reveals patients do not report better health status despite gains in life expectancy due to advances in cancer treatment
Patient safety benefits when hospitals provide feedback to staff who report errors
To improve patient safety, hospital leaders should provide feedback that demonstrates to staff the value of reporting safety events and errors.
Researchers reveal genomic landscape of core-binding factor acute myeloid leukemia
Research from the Pediatric Cancer Genome Project identifies genomic landscape that contributes to the diversity of core-binding factor acute myeloid leukemia.
Genetic hallmarks of acute lymphoblastic leukemia subtype uncovered
Research from the Pediatric Cancer Genome Project identifies the mechanism of action for two transcription factors underlying a type of B-precursor acute lymphoblastic leukemia.
Toxic peptides disrupt membrane-less organelles in neurodegenerative disease
New findings help increase understanding of molecular mechanisms for common forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Janice English named director of Patient and Family Experience Office at St. Jude Children’s Research Hospital
Under her direction, the office leads a concentrated effort to enhance the patient and family experience at St. Jude.
Triple-drug chemotherapy with topotecan helps preserve vision in retinoblastoma patients
Chemotherapy drug topotecan aids cure and vision preservation in patients with advanced retinoblastoma, while reducing risk of treatment late effects.
Scientists reveal how signals from pathogenic bacteria reach danger sensors of cells
Researchers identify the molecular events that activate inflammasomes to initiate the innate immune response against bacterial invaders.
Newly discovered immune cell type protects against lung infections during chemotherapy
Newly recognized lung macrophage protects chemotherapy-treated mice with a depleted immune system from lethal bacterial pneumonia
New mobile health app will help sickle cell patients stay healthy
National Institutes of Health funding will help physicians and researchers improve hydroxyurea treatment management for sickle cell patients in Memphis.
St. Jude and Methodist Healthcare sign agreement to advance center for adult sickle cell disease in Memphis
The newly expanded Methodist Comprehensive Sickle Cell Center will strengthen research into sickle cell disease and serve the growing needs of patients in the Memphis area.
St. Jude Children’s Research Hospital and Sanger Institute, UK collaborate to make data beautiful
Proteinpaint database collaboration will make it easier for any scientist to explore cancer genome data.
Applications now being accepted for inaugural class of St. Jude Graduate School of Biomedical Sciences
The new doctoral program will focus on translational research and integrated approaches to discover better treatments and cures for pediatric diseases.
Stem cell propagation fuels cancer risk in different organs
St. Jude researchers provide experimental evidence to demonstrate how stem cells contribute to cancer risk.
St. Jude Children’s Research Hospital appoints scientific director
James Morgan, Ph.D., will lead the institution’s basic science programs
CRISPR gene editing reveals new therapeutic approach for blood disorders
Researchers found a way to use genome editing to help fix sickle cell disease and beta-thalassemia in blood cells isolated from patients.
St. Jude researchers pinpoint key influenza-fighting immune trigger
Molecular "master assassin" identified that recognizes flu-infected cells and triggers cell death, raises hope for drugs to prevent flu complications.
Rare genetic variations may solve mystery of porphyria severity in some patients
Variations in a porphyrin transport protein may affect symptom severity in patients with porphyria, a rare disorder of skin, liver and nervous system.
Vaccines fail to protect obese mice from severe influenza infections
The addition of adjuvants to influenza vaccines offers no protection from severe flu infections in study looking at obesity.
Novel statistical method captures long-term health burden of pediatric cancer cures
Researchers develop “cumulative burden” statistical method to measure and address the impact of chronic disease in childhood cancer survivors
Evidence suggests migratory birds are not a reservoir for highly pathogenic flu viruses
Influenza surveillance in migratory waterfowl suggests that highly pathogenic avian flu viruses do not persist in wild aquatic birds
Pharmacogenetics experts establish common vocabulary in bid to advance precision medicine
Experts have developed a list of preferred terms to promote standardize reporting of pharmacogenetic test results in patients’ health records
Some adolescent cancer survivors may require more comprehensive mental health screening
Study shows that most teen cancer survivors do well psychologically, but cancer treatment may influence some survivors’ symptoms
Loss of essential protein in the choroid plexus epithelium linked to hydrocephalus
Multifunctional protein Alix identified as essential for maintaining fluid balance in the brain; loss is linked to hydrocephalus.
St. Jude becomes first children’s hospital in U.S. to earn CAP ISO15189 accreditation
The Department of Pathology has been accredited by The College of American Pathologists (CAP), a Centers for Medicare and Medicaid Services (CMS)-approved accreditation authority.
St. Jude Children’s Research Hospital scientist named Pew-Stewart Scholar
St. Jude scientist studying medulloblastoma is named Pew-Stewart Scholar for Cancer Research, which supports innovative early career researchers
St. Jude Children's Research Hospital names Department of Developmental Neurobiology chair
Michael Dyer, Ph.D., to chair the department and build a team of international leaders in neural development, synapse formation and neural circuit formation.
Methotrexate exposure impacts cognitive processes cancer survivors need to multitask
Higher blood levels of methotrexate during treatment of childhood leukemia have been linked to diminished executive function in long-term survivors.
St. Jude Children’s Research Hospital research being presented at ASCO Annual Meeting
St. Jude experts present their research at the annual meeting of the American Society of Clinical Oncology in Chicago.
Investigational immunotherapy drug shrinks tumors in high-risk neuroblastoma patients
Preliminary report: Neuroblastoma tumors shrank in more pediatric patients when experimental immunotherapy was combined with chemotherapy
James R. Downing, M.D., tells podcast audience about St. Jude mission and global goals
St. Jude president and chief executive officer discusses giving all children the best chance against cancer and other illnesses on the Innovate podcast series.
Enzyme pair play crucial role in maintaining balance of cellular processes
Enzymes best known for their role in autophagy also play a pivotal role in protein trafficking that helps maintain brain cell health.
Children with brain tumors undergoing radiation therapy helped by play-based preparation
Child life specialists show support interventions decrease sedation use for radiation therapy.
Modeling and simulation help optimize chemotherapy to combat brain tumor
Pharmacologic modeling and simulation help translate preclinical data into phase I trial of the drug 5-FU for treatment of brain tumor ependymoma.
Targeted antibiotic is easier on the gut microbiome
Pathogen-specific antibiotic is less likely to kill good bacteria in gut, raising hopes for reduced side effects caused by disruption of microbiome.
Risk factors identified for acute pancreatitis that can disrupt leukemia treatment
Native American ancestry and rare CPA2 gene variation may leave some leukemia patients at risk of pancreatitis following treatment with asparaginase.
Gene therapy pioneered at St. Jude shows early success against "bubble boy" disease
Health and immune function improved in patients with X-linked SCID, or bubble boy disease, who underwent gene therapy after other treatments failed.
Defects in the body’s cell disposal system may contribute to the most common form of lupus
A casual observation leads to discovery that defects in a cell disposal system called LAP may lead to a lupus-like autoimmune disorder
James R. Downing, M.D., of St. Jude, elected to the American Academy of Arts and Sciences
St. Jude Children’s Research Hospital president and CEO joins the 236th class of members, which includes national and international scholars, artists, philanthropists and leaders.
St. Jude researchers reveal how two types of immune cells can arise from one
Lopsided distribution of the signaling protein c-Myc plays a critical role in determining T cell destiny during asymmetric cell division.
James R. Downing, M.D., of St. Jude, to advise National Cancer Moonshot Initiative
The Blue Ribbon Panel will serve as a working group for presidentially-appointed National Cancer Advisory Board.
St. Jude research will guide development of new anti-influenza drugs
Researchers lay the foundation for a new class of influenza drugs that will be tougher for flu viruses to resist.
Maternal bacterial infections trigger abnormal proliferation of neurons in fetal brain
Neuronal proliferation, not cell death, may help explain why bacterial infections during pregnancy lead to cognitive problems in children.
St. Jude Children's Research Hospital named to Fortune magazine’s "100 Best Companies to Work For" for sixth consecutive year
St. Jude was included again on Fortune's annual list for having exceptional workplace culture based upon employee surveys and an in-depth questionnaire.
Scientists reveal alternative route for cell death
The protein BOK is involved in the mitochondrial cell death pathway, discovered by St. Jude researchers. This pathway ensures the rapid, programmed destruction of the cell and its contents.
Protein revealed as glue that holds biomolecules within the nucleolus
Research reveals how the protein NPM1 lays foundation for ribosome assembly in the nucleolus through a process called liquid-liquid phase separation.
Capsule Shedding: A new bacterial pathway that promotes invasive disease
Suicide enzyme LytA helps pneumococcus bacteria rapidly shed capsule to evade early immune response and set the stage for invasive disease
Discovery of likely subtypes of rare childhood brain tumor signals diagnostic advance
Molecular classification of rare brain tumors CNS-PNET likely to improve diagnosis and set stage for targeted therapies.
Newly identified genes impact how transplanted stem cells give rise to blood cells
Researchers investigate methods to enhance the utilization of blood-forming stem cells by identifying genes needed for successful transplantation.
Discovery lays the foundation to expand personalized chemotherapy for leukemia patients
Researchers show how inherited variations in NUDT15 gene, which are most common in Asian and Hispanic patients, cause thiopurine drug toxicity.
St. Jude Children’s Research Hospital welcomes Pat Keel as chief financial officer
Keel will lead the financial strategy and management for St. Jude to reach the hospital’s goals of growth and innovation.
Attention problems persist in childhood leukemia survivors treated with chemotherapy alone
Despite an end to cranial irradiation for treatment of pediatric acute lymphoblastic leukemia (ALL), survivors remain at risk for attention problems.
Scientists discover a unique mechanism for a high-risk leukemia
St. Jude researchers discover how chromosomal rearrangements trigger a high-risk acute lymphoblastic leukemia, and identify strong treatment leads.
Study finds significant cognitive impairment in adult survivors of childhood brain tumors
St. Jude LIFE study reports that decades after treatment, adult survivors of childhood brain tumors often face significant cognitive challenges.
Drug counters effects of excessive inflammation arising from immune disorder
Researchers demonstrate drugs’ effectiveness in targeting immune reactions and show potential clinical trial application.
Researchers mine the epigenome to identify likely origins of childhood brain tumor subtype
Epigenome yields insights into medulloblastoma, the most common malignant pediatric brain tumor, including likely cell of origin for Group 4 subtype.
Acid-sensitive molecular changes contribute to the emergence of pandemic influenza
Tracking the 2009 H1N1 pandemic flu virus revealed that hemagglutinin acid stability is required for person-to-person spread of pandemic viruses.
Sequencing reveals genetic alterations for uncommon brain tumors in children
Pediatric Cancer Genome Project identifies high-frequency driver mutations in low-grade neuroepithelial tumors that may lead to new treatment options.
Discovery reveals how protective immune cells protect themselves
Mechanism identified that protects regulatory T cells working to maintain balanced immune response; may offer possible immune therapies for cancer.
New drug target identified for X-linked lymphoproliferative disease
Study shows that inhibition of enzyme could reverse life-threatening effects of immunodeficiency disease.
Long-term survivors of childhood cancer living longer thanks in part to treatment changes
Study shows the 15-year death rate among childhood cancer survivors has decreased steadily since 1970, coinciding with changes in pediatric cancer therapy and follow-up care.
Scientists identify protein interaction that defines an aggressive brain tumor subtype
Researchers identify Myc-Miz1 protein interaction as a hallmark of aggressive group 3 medulloblastoma tumors and also a potential treatment.
St. Jude Children’s Research Hospital names police department veteran Toney Armstrong director of security
Armstrong joins St. Jude to oversee all security operations on the hospital’s growing campus and in its patient housing facilities.