Memory T cells responsible for long-term immunity have been cross-trained
Advances in understanding the origins of memory CD8 T cells should aid efforts to create more effective vaccines and immunotherapies to help protect against cancer relapse.
St. Jude gene therapy improves immunity in babies with 'bubble boy' disease
Early results suggest gene therapy is well tolerated and effective for babies with X-linked severe combined immunodeficiency disorder, or "bubble boy" disease.
St. Jude Children's Research Hospital named to Glassdoor's Best Places to Work 2018
St. Jude ranks 9 out of Top 100 large companies on Glassdoor’s Best Places to Work 2018 list.
Anti-malaria drug increases sensitivity of high-risk leukemic cells to targeted therapy
A drug widely used against malaria sensitizes the high-risk leukemia BCR-ABL positive ALL to a precision medicine and may enhance treatment.
St. Jude at the American Society of Hematology 2017 annual meeting
St. Jude scientists, clinicians and leadership highlighted at the annual American Society of Hematology in Atlanta. Read the latest.
Researchers discover an Achilles heel in a lethal leukemia
Researchers have discovered how a linkage between two proteins in AML enables cancer cells to resist chemotherapy- disrupting the linkage could become a treatment pathway.
Increasing hydroxyurea dose helps to keep young sickle cell patients out of the hospital
Higher doses of hydroxyurea in children with sickle cell disease boosts their fetal hemoglobin levels and significantly reduces hospitalizations.
New pathway identified as a target for precision medicine against a common brain tumor
A newly identified component of the Sonic Hedgehog pathway offers another target for precision medicine for treatment of SHH medulloblastoma subtype
Flu vaccine failed to protect young leukemia patients during cancer treatment
The flu shot may not protect pediatric leukemia patients from influenza during cancer treatment, highlighting the need for additional safeguards.
Sperm banking is underutilized by adolescent and young adult cancer patients
Despite the fertility risk, most young male cancer patients don’t bank sperm before beginning cancer treatment.
Researchers discover how enzyme 'shape-shifts' in drug-resistant leukemia
New treatment strategies to overcome drug resistance in chronic myelogenous leukemia and other cancers will come from the detailed structure of the enzyme Abl.
Life-long blood production depends on hundreds of cells that form prior to birth
How many blood-forming stem cells are present at birth to keep us supplied with blood cells for a lifetime? It is more than previously thought.
Antibiotic identified that reduces infection risk in young leukemia patients
Prophylactic antibiotic therapy with levofloxacin is safe and effective for reducing treatment-related infections in pediatric leukemia patients.
Comprehensive study of chronic disease reveals vulnerability of childhood cancer survivors
The severity and complexity of chronic disease in adult survivors of childhood cancer suggest that a new approach to healthcare delivery is needed.
St. Jude unveils powerful resource to advance treatment of pediatric solid tumors
Childhood Solid Tumor Network offers the world’s largest and most comprehensive collection of scientific resources for studying pediatric solid tumors
HPV vaccination rates lag for vulnerable population of childhood cancer survivors
Health provider recommendation most important predictor of HPV vaccination of adolescent and young adult survivors of childhood cancer.
Allergies? Exhausted regulatory T cells may play a role
Regulatory T cells show evidence of functional exhaustion in research that underscores the importance of immunometabolism for immune balance.
Researchers discover fundamental pathology behind ALS
Identifying the basic cellular malfunction underlying ALS opens the pathway to developing treatments to prevent the disease by preserving neurons.
Discovery points to drugs that would ‘short-circuit’ deadly leukemia
St. Jude researchers have found that cells of a deadly acute myeloid leukemia can be killed by blocking production of a molecular “battery.”
St. Jude names Charalampos Kalodimos chair of Department of Structural Biology
Dr. Kalodimos’ appointment will further strengthen basic science programs that serve as the foundation of discovery.
St. Jude Children's Research Hospital signs agreement to commercialize RSV vaccine
Agreement with Serum Institute of India to develop a vaccine for respiratory syncytial virus, a lower respiratory tract infection in infants and children.
Boat-shaped membrane protein offers novel solution for working in the cell membrane
Novel boat-shaped membrane protein provides an architectural solution for PlsC and likely thousands of other enzymes that work within the cell membrane.
Definitive genomic study reveals alterations driving most medulloblastoma brain tumors
Landmark study of the most common pediatric brain tumor reveals new cancer genes and lays the foundation to expand precision medicine.
Engineered yeast yields insight into machinery of deadly brain tumor
Researchers offer clues on how mutations in the histone H3 cripple DNA replication and genomic instability, which contribute to development of high-grade glioma.
Newly identified genetic marker may help detect high-risk flu patients
Researchers have identified a possible genetic marker of influenza severity and evidence it affects the supply of killer T cells that help fight the infection.
Improved recognition to help fertility preservation for cancer patients
Premature ovarian insufficiency leaves childhood cancer survivors at risk for infertility, weak bones and poor health.
Genomic analysis of key acute leukemia will likely yield new therapies
Landmark study of T-lineage acute lymphoblastic leukemia (T-ALL) reveals new mutations and drug development targets.
Controlling a single brain chemical may help expand window for learning language and music
Extending the age window for learning language and music may depend on dialing down the neuromodulator adenosine.
Researchers chart pathway to 'rejuvenating' immune cells to fight cancers
Enhanced immunotherapies against cancer and viral infections may be on the horizon thanks to a new strategy to combat T cell exhaustion.
U.S. News & World Report Ranks St. Jude Children’s Research Hospital as No. 1 Pediatric Cancer Hospital
St. Jude recognized among hospitals that delivered exceptionally high-quality care among multiple specialties.
St. Jude Children’s Research Hospital adds new leadership members for Clinical Trials Administration
Denise Roe and Tangie Thomas will join as leaders in the growing Clinical Trials Administration department.
Researchers create a ‘Rosetta Stone’ to decode immune recognition
A new algorithm helps decode how T cells recognize antigens, which should aid efforts to harness the immune system against cancer and infections.
Researchers identify a key controller of biological machinery in cell’s ‘antenna’
Discovery of new molecular control switches for cellular machinery offers invaluable new research pathways for understanding and treating diseases.
Chronic health conditions among childhood cancer survivors decrease
Research from Childhood Cancer Survivor Study finds improvements in therapies have reduced the incidence of serious chronic late health effects in survivors.
ASCO 2017 will feature research from a variety of St. Jude experts
St. Jude experts present pediatric oncology and survivorship research at the annual meeting of the American Society of Clinical Oncology.
A new strategy reported to combat influenza and speed recovery
Influenza hijacks cell metabolism and revs up production of new virus. The investigational cancer drug BEZ235 reverses that and speeds flu recovery.
St. Jude Children's Research Hospital CEO and a hospital faculty member recognized for contributions to cancer research
James R. Downing, M.D., and Charles Mullighan, MBBS, M.D., have received awards from prestigious cancer research institutions.
St. Jude maps genome organization to link retinal development and retinoblastoma
Epigenetic map reveals molecular switches that control development of both the normal retina and the eye cancer retinoblastoma.
Researchers unlock an immunity ’black box’
The immune machinery that drives the skin disease neutrophilic dermatosis (Sweet’s syndrome) reveals clues for taming the immune response
Success of sensory cell regeneration raises hope for hearing restoration
Manipulating two genes sparked regeneration of sensory hair cells in adult mice. The finding advances treatment of a leading cause of hearing loss.
Time-lapse video reveals cells essential for 'birth' of blood stem cells
Neural crest cells revealed as key to hematopoietic stem cell production in the body.
Rescue protein gives doomed cells a stay of 'execution'
Discovery of the protein that delays cell death could aid transplant survival and offer treatment for cancer, neurodegeneration and infection
Study finds more childhood cancer survivors would likely benefit from genetic screening
Learn what whole genome sequencing reveals about the lifetime cancer risk of childhood cancer survivors and who may benefit from genetic screening.
St. Jude Researchers at AACR 2017
Explore research being presented by St. Jude investigators at the annual meeting of the American Association for Cancer Research (AACR) in Washington, D.C.
Caution needed for drugs in development for most common malignant pediatric brain tumor
Inhibiting the Ezh2 enzyme may be counterproductive for treatment of certain cancers, including the aggressive brain tumor Group 3 medulloblastoma
St. Jude names research tower for Donald Pinkel, M.D., in honor of his legacy of finding cures for childhood cancers
Pioneering physician sets first cure rate for children with acute lymphoblastic leukemia (ALL)
St. Jude Children's Research Hospital named to Fortune magazine’s ‘100 Best Companies to Work For’ for seventh consecutive year
St. Jude recognized for having exceptional workplace culture based upon employee surveys and an in-depth questionnaire.
New grant expands reach of St. Jude gene therapy program for "bubble boy" disease
The new grant supports the opening of the St. Jude gene therapy protocol for X-linked SCID at the University of California, San Francisco (UCSF) Benioff Children's Hospital San Francisco.
Stephen Gottschalk, M.D., named chair of the Department of Bone Marrow Transplantation and Cellular Therapy
In his new position, Gottschalk will be responsible for management of the department’s clinical, research and educational activities.
Infant’s prolonged infection reveals mutation that helps bacteria tolerate antibiotics
Prolonged infection in infant with leukemia led to discovery of a mutation in the stringent response pathway that helps bacteria tolerate antibiotics.