Junmin Peng, PhD
Junmin Peng, PhD

Junmin Peng, PhD

Associate Member, St. Jude Faculty

  • Director, Proteomics Facility



BS – Wuhan University, Wuhan, China
PhD – University of Iowa
Postdoctoral Fellowship – Harvard Medical School

Research Interests

  • Development of high-throughput proteomics tools
  • Analysis and function of protein ubiquitination
  • Proteomics in neurodevelopment and neurodegeneration
  • Cancer proteomics

Selected Publications

See Dr. Peng's citations on Google Scholar.

Wang X, Li Y, Wu Z, Wang H, Tan H and Peng J. JUMP: a tag-based database search tool for peptide identification with high sensitivity and accuracy. Mol Cell Proteomics September 8, 2014. Epub ahead of print.

Jones DR, Wu Z, Chauhan D, Anderson KC, Peng J. A nano Ultra-Performance Liquid Chromatography - High Resolution Mass Spectrometry Approach for Global Metabolomic Profiling and Case Study on Drug-Resistant Multiple Myeloma. Anal Chem 86:3667-75, 2014.

Jacobson AD, Macfadden A, Wu Z, Peng J, Liu CW. Autoregulation of the 26S Proteasome by in situ Ubiquitination. Mol Biol Cell 25:1824-35, 2014.

Xu Y, Gao XD, Lee JH, Huang H, Tan H, Ahn J, Reinke LM, Peter ME, Feng Y, Gius D, Siziopikou KP,Peng J, Xiao X, Cheng C. Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing. Genes Dev 28:1191-203, 2014.

Bai B, Chen PC, Hales CM, Wu Z, Pagala V, High AA, Levey AI, Lah JJ, Peng J. Integrated Approaches for Analyzing U1-70K Cleavage in Alzheimer's disease. J Proteome Res Jun 13, 2014. Epub ahead of print.

Bai B, Hales CM, Chen PC, Gozal Y, Dammer EB, Fritz JJ, Wang X, Xia Q, Duong DM, Street C, Cantero G, Cheng D, Jones DR, Wu Z, Li Y, Diner I, Heilman CJ, Rees HD, Wu H, Lin L, Szulwach KE, Gearing M, Mufson EJ, Bennett DA, Montine TJ, Seyfried NT, Wingo TS, Sun YE, Jin P, Hanfelt J, Willcock DM, Levey A, Lah JJ, Peng J. U1 Small Nuclear Ribonucleoprotein Complex and RNA Splicing Alterations in Alzheimer’s Disease Proc Natl Acad Sci USA 110:16562-7, 2013.

Willmund F, Del Alamo M, Pechmann S, Chen T, Albanèse V, Dammer EB, Peng J, Frydman J. The cotranslational function of ribosome-associated hsp70 in eukaryotic protein homeostasis. Cell 152:196-209, 2013.

Shu C, Sankaran B, Chaton CT, Herr AB, Mishra A, Peng J, Li P. Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity. Structure 21:1137-48, 2013

Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis J Proteome Res 11:4722-32, 2012.

Xu P, Tan H, Duong DM, Yang Y, Kupsco J, Moberg KH, Li H, Jin P, Peng J. Stable Isotope Labeling with Amino Acids in Drosophila for Quantifying Proteins and Modifications. J Proteome Res 11:4403-12, 2012.

Xie L, Pi X, Mishra A, Fong G, Peng J, Patterson C. PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response. J Clin Invest 122:2827-36, 2012.

Seyfried NT, Gozal YM, Donovan LE, Herskowitz JH, Dammer EB, Xia Q, Ku L, Chang J, Duong DM, Rees HD, Cooper DS, Glass JD, Gearing M, Tansey MG, Lah JJ, Feng Y, Levey A, Peng J. Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards. J Proteome Res 11:2721-38, 2012.

Felberbaum R, Wilson NR, Cheng D, Peng J, Hochstrasser M. Desumoylation of the ER Membrane VAP Protein Scs2 by Ulp1 and SUMO Regulation of the Inositol Synthesis Pathway. Mol Cell Biol 32:64-75, 2012.

Scaglione KM, Zavodszky E, Todi SV, Patury S, Xu P, Rodríguez-Lebrón E, Fischer S, Konen J, Djarmati A, Peng J, Gestwicki JE, Paulson HL Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP. Mol Cell 43:599-612, 2011.

Dammer EB, Na CH, Xu P, Seyfried NT, Duong DM, Cheng D, Gearing M, Rees H, Lah JJ, Levey AI, Rush J, Peng J. Polyubiquitin linkage profiles in three models of proteolytic stress suggest etiology of Alzheimer disease. J Biol Chem 286:10457-65, 2011.

Franco M, Seyfried NT, Brand AH, Peng J*, Mayor U*. A novel strategy to isolate ubiquitin conjugates reveals wide role of ubiquitination during neural development. Mol Cell Proteomics 10:M110.002188, 2011. *Co-corresponding authors.

Bingol B, Wang CF, Arnott D, Cheng D, Peng J, Sheng M. Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spines. Cell 140:567-578, 2010.

Seyfried NT, Gozal YM, Dammer EB, Xia Q, Duong DM, Cheng D, Lah JJ, Levey AI, Peng J. Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyUb chains. Mol Cell Proteomics 9:705-18, 2010.

Zhou JY, Afjehi-Sadat L, Asress S, Duong DM, Cudkowicz M, Glass JD, Peng J. Galectin-3 is a candidate biomarker for ALS: Discovery by a proteomics approach. J Proteome Res 9:5133-41, 2010.

Xu P, Duong DM, Seyfried NT, Cheng D, Xie Y, Robert J, Rush J, Hochstrasser M, Finley D, Peng J. Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell 137:133-145, 2009.

Xu P, Duong DM, Xia Q, Peng J. Systematical optimization of reverse-phase chromatography for protein identification. J Proteome Res 8:3944-50, 2009.

Liu Y, Ye X, Jiang F, Liang C, Cheng D, Peng J, Kinch L, Grishin N, Liu Q. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science 325:750-753, 2009.

Edbauer D, Cheng D, Batterton MN, Wang CF, Duong DM, Yaffe MB, Peng J*, Sheng M. Identification and characterization of neuronal MAP kinase substrates using a specific phosphomotif antibody. Mol Cell Proteomics 8:681-98, 2009. *Co-corresponding author.

Gozal YM, Duong DM, Gearing M, Cheng D, Hanfelt J, Funderburk C, Peng J*, Lah JJ, Levey AI. Proteomics analysis reveals novel components in the detergent-insoluble subproteome in Alzheimer’s disease. J Proteome Res 8:5069-79, 2009. *Co-corresponding author.

Qi HH, Ongusaha PP, Myllyharju J, Cheng D, Pakkanen O, Shi Y, Lee SW, Peng J, Shi Y. Prolyl 4-hydroxylation regulates Argonaute 2 stability. Nature 455:421-4, 2008.

Xia Q, Cheng D, Duong DM, Gearing M, Lah JJ, Levey AI, Peng J. Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry. J Proteome Res 7:2845-51, 2008.

Xu P, Peng J. Characterization of polyubiquitin chain structure by middle-down mass spectrometry. Anal Chem 80:3438-44, 2008.

Seyfried N, Xu P, Duong DM, Cheng D, Hanfelt J, Peng J. A systematic approach to validating ubiquitinated proteome. Anal Chem 80:4161-9, 2008.

Choe EA, Liao L, Zhou, JY, Cheng D, Duong DM, Jin P, Tsai LH, Peng J. Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. J Neurosci 27:9503-9512, 2007.

Last update: September 2014