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Nutrients and organelle signaling shape tissue immunity
10/14/2024
Discover research by Hongbo Chi, PhD, that uncovers the interplay between organelles, nutrient-dependent signaling pathways and tissue immunity.
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Disrupting Asxl1 gene prevents T-cell exhaustion, improving immunotherapy
10/10/2024
Explore how disruptions in ASXL1 were correlated with better patient responses to immune checkpoint inhibition and long-term tumor control in model systems.
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St. Jude ranks in top 10 of U.S. News Best Children's Hospitals for Cancer
10/08/2024
US News & World Report has recognized St. Jude Children's Research Hospital as one of the top 10 pediatric cancer hospitals for the 17th straight year.
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St. Jude names M. Madan Babu, PhD, senior vice president and chief data scientist
10/01/2024
M. Madan Babu, PhD, will lead new $195 million data science enterprise for biologic discovery to advance pediatric medicine.
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Structure of a eukaryotic CRISPR-Cas homolog, Fanzor2, shows its promise for gene editing
10/01/2024
See how structures of Fanzor2, a relation of the transposon family TnpB, show how the protein can be used in genome engineering technology like CRISPR-Cas9.
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Clinical trial results show low-intensity therapy can achieve positive outcomes for certain pediatric leukemia subtypes
09/24/2024
Learn about St. Jude clinical trial findings from Hiroto Inaba, MD, PhD, showing that genomics can guide risk assessment and leukemia treatment intensity.
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Urate transporter structures reveal the mechanism behind important drug target for gout
09/09/2024
Discover how cryo-EM insights into URAT1, a urate transporter and member of the SLC22 transporter family advance gout and hypouricemia drug discovery
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Early interventions may improve long-term academic achievement in young childhood brain tumor survivors
08/21/2024
Find how children who survive a brain tumor often fall behind peers in academic readiness, but access to early developmental resources may reduce the gap.
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T helper cells may be the key to improving annual influenza vaccines
08/20/2024
Explore how T follicular helper cells indirectly control the anti-influenza immune response, which could lead to improvements in annual flu vaccine design.
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First successful treatment of pediatric high-risk refractory neuroblastoma with PARP inhibition
08/14/2024
Explore the first successful treatment of a pediatric patient with high-risk refractory neuroblastoma using PARP inhibition guided by clinical genomics.
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