Research News & Publications

Modular chimeric cytokine receptors improve CAR T–cell therapy for solid tumors

11/30/2023

Adding a modular chimeric cytokine receptor to CAR T cells increased their efficacy. Learn how this modular system could improve brain and solid tumor therapy.
St. Jude revealed functional targets of oncogenic HOXA9 in high-risk pediatric leukemia

11/28/2023

St. Jude scientists identified 229 genes regulated by undruggable oncogenic HOXA9. Learn how it may lead to better treatments for high risk pediatric leukemias.
Promising target for CAR T Cells helps cancer trick the immune system

11/21/2023

GRP78 is a promising CAR T-cell immunotherapy target for brain and solid tumors. Discover why it’s special, including how cancer uses it to trick immune cells.
Robust chromatin map explains heterogeneity of pediatric acute lymphoblastic leukemia

11/20/2023

Find how mapping chromatin accessibility & regulation in pediatric acute lymphoblastic leukemia (ALL) subtypes may uncover therapy response heterogeneity cause.
St. Jude scientists identify T-cell differentiation nodes to improve cancer-killing

11/15/2023

Discover how T-cell differentiation nodes can be promoted or blocked to improve immunotherapy anticancer efficacy according to new T-cell exhaustion research.
Fusion oncoprotein forces cell fates toward rhabdomyosarcoma

11/15/2023

Fusion positive pediatric rhabdomyosarcoma (RBD) can come from non-muscle cells with a fusion oncoprotein. Find how the St. Jude discovery may change treatment.
‘Highly cited’ St. Jude scientists named to annual list

11/15/2023

Learn more about the St. Jude scientists who are among the most highly cited researchers in the world, a distinction that reflects the value of their work among other investigators.
Giles Robinson, M.D., named director of the Neuro-Oncology Division at St. Jude Children’s Research Hospital

11/07/2023

Dr. Robinson is now also co-leader of the Neurobiology and Brain Tumor Program in the St. Jude Comprehensive Cancer Center.
Scientists reveal structures of neurotransmitter transporter

11/01/2023

See how researchers at St. Jude Children’s Research Hospital used cryo-electron microscopy to solve structures of a neurotransmitter (dopamine, serotonin) transporter VMAT2 responsible for packing vesicles in neurons for signaling.
3D genome architecture influences SCID-X1 gene therapy success

10/06/2023

Lentiviral gene therapy for X-linked severe combined immunodeficiency disorder (SCID-X1) is safe. Discover how 3D DNA structure explains biology & safety.