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Modular chimeric cytokine receptors improve CAR T–cell therapy for solid tumors
11/30/2023
Adding a modular chimeric cytokine receptor to CAR T cells increased their efficacy. Learn how this modular system could improve brain and solid tumor therapy.
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St. Jude revealed functional targets of oncogenic HOXA9 in high-risk pediatric leukemia
11/28/2023
St. Jude scientists identified 229 genes regulated by undruggable oncogenic HOXA9. Learn how it may lead to better treatments for high risk pediatric leukemias.
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Promising target for CAR T Cells helps cancer trick the immune system
11/21/2023
GRP78 is a promising CAR T-cell immunotherapy target for brain and solid tumors. Discover why it’s special, including how cancer uses it to trick immune cells.
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Robust chromatin map explains heterogeneity of pediatric acute lymphoblastic leukemia
11/20/2023
Find how mapping chromatin accessibility & regulation in pediatric acute lymphoblastic leukemia (ALL) subtypes may uncover therapy response heterogeneity cause.
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St. Jude scientists identify T-cell differentiation nodes to improve cancer-killing
11/15/2023
Discover how T-cell differentiation nodes can be promoted or blocked to improve immunotherapy anticancer efficacy according to new T-cell exhaustion research.
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Fusion oncoprotein forces cell fates toward rhabdomyosarcoma
11/15/2023
Fusion positive pediatric rhabdomyosarcoma (RBD) can come from non-muscle cells with a fusion oncoprotein. Find how the St. Jude discovery may change treatment.
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‘Highly cited’ St. Jude scientists named to annual list
11/15/2023
Learn more about the St. Jude scientists who are among the most highly cited researchers in the world, a distinction that reflects the value of their work among other investigators.
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Giles Robinson, M.D., named director of the Neuro-Oncology Division at St. Jude Children’s Research Hospital
11/07/2023
Dr. Robinson is now also co-leader of the Neurobiology and Brain Tumor Program in the St. Jude Comprehensive Cancer Center.
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Scientists reveal structures of neurotransmitter transporter
11/01/2023
See how researchers at St. Jude Children’s Research Hospital used cryo-electron microscopy to solve structures of a neurotransmitter (dopamine, serotonin) transporter VMAT2 responsible for packing vesicles in neurons for signaling.
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3D genome architecture influences SCID-X1 gene therapy success
10/06/2023
Lentiviral gene therapy for X-linked severe combined immunodeficiency disorder (SCID-X1) is safe. Discover how 3D DNA structure explains biology & safety.
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Scientific Report 2023
The Scientific Report, Translating Science into Survival, describes key breakthroughs made by St. Jude investigators.
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