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James R. Downing, MD, to step down as president and CEO of St. Jude Children’s Research Hospital in late 2026
02/19/2026
Dr. Downing led St. Jude to unprecedented growth over the last 12 years.
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Classifying pediatric brain tumors by liquid biopsy using artificial intelligence
02/17/2026
See how M-PACT, an AI-powered algorithm can sift through ctDNA in cerebrospinal fluid and molecularly classify tumors based on their DNA methylation pattern
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Studies show that less frequent, all-injectable treatment for HIV is safe and preferred by adolescents
01/15/2026
Dive into a St. Jude co-led clinical trial finding long-acting injectable HIV treatment is safe, effective & preferred by adolescents in multiple countries.
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Retrotransposon drives cancer by altering 3D genome structure
01/05/2026
See how LINE-1 retrotransposon jumping gene loci modulate cancer gene expression by altering three-dimensional genome architecture at select sites called HILLs.
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CHANGE-seq-BE finds off-target changes in the genome from base editors
01/02/2026
Find how Circularization for High-throughput Analysis of Nuclease Genome-wide Effects by Sequencing Base Editors (CHANGE-seq-BE) improves finding off-targets.
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Structural findings reveal how distinct GPCR ligands create different levels of activation
12/22/2025
Find how GPCR G-protein activation differs between ligands, with partial agonists stuck longer in “kinetic traps” of intermediate states during the process.
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Revealing an invisible kinase state that accounts for vital biological function
12/18/2025
Learn how St. Jude scientists uncovered a hidden Src kinase state crucial for T-cell activation and cell migration, opening new paths for therapies.
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Combination therapy shows potential to treat pediatric brain cancer ATRT
12/16/2025
See how a combo therapy of idasantulin and Selinexor stimulate the p53 pathway through MDM2 and XPO1 to treat atypical teratoid rhabdoid tumors (ATRT)
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Accelerating drug combination discovery with machine learning
12/15/2025
Explore ComboCat, a St. Jude scientist-created system that combines machine learning and advanced liquid handling to speed up combination drug discovery.
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Membrane ‘neighborhood’ helps transporter protein regulate cell signaling
12/05/2025
See how protein kinase A, SCRIB, and other proteins help keep ABCC4 transporter levels steady in the membrane to regulate cyclic AMP signaling
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Pediatric Cancer Genome Project
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