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Findings demonstrate how mutation disrupts cell development, driving region-specific brain tumors
08/26/2026
Discover how St. Jude researchers uncovered how regional differences in the developing brain shape diffuse midline glioma formation.
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Removing immune ‘brake’ improves CAR T–cell therapy for osteosarcoma
08/25/2026
Explore a cellular immunotherapy that controlled relapsed bone cancer and prevented metastasis in model systems, setting the foundation for a clinical trial.
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Single-cell atlas reveals how spinal neurons help coordinate walking and other rhythmic movements
08/10/2026
Explore new St. Jude research uncovering a special set of interneurons that governs how the brain controls the speed of certain repetitive body movements.
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MBNL1 was identified as a potential cancer drug target for a type of childhood leukemia
08/07/2026
Discover how the RNA-binding protein MBNL1 binds single-stranded DNA to promote a difficult-to-treat childhood cancer.
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Restoring the silenced Friedreich’s ataxia gene through unconventional means
08/05/2026
See how a synthetic gene regulating SynGR system desilenced the frataxin gene in Friedreich’s ataxia by shuttling BRD4 through HP1 condensates
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A lipid regulator of Sonic hedgehog signaling influences heart and lung development
07/27/2026
Discover how St. Jude researchers discovered a new mechanism that enhances Sonic hedgehog signaling during heart and lung development.
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Premature blood stem cell aging in sickle cell disease may be reversible
07/22/2026
Discover how patients with sickle cell disease have accelerated aging in their blood stem cells, but anti-aging senolytics may help, and improve gene therapy.
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Antibiotic-tolerant bacteria rely on a hidden survival strategy
07/22/2026
See how bacteria survive antibiotic treatment by entering a temporary state of tolerance driven by changes in RNA regulation.
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Targeting RBM5 may help disrupt ‘undruggable’ MYC in childhood leukemia
07/16/2026
Learn how RBM5 helps drive disease while being dispensable in normal blood-forming cells, offering a potential high-efficacy, low toxicity therapeutic target.
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Research explains how nucleolus sub-compartments drive ribosome assembly
07/15/2026
See how RNA and SURF6 sub-compartments surrounded by NPM1 help in ribosome biogenesis within the nucleolus granular component condensate
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