The annual Bringing Chemistry to Medicine symposium features thought leaders at the interface of chemical and biomedical sciences and is hosted by the St. Jude Department of Chemical Biology and Therapeutics and the St. Jude Comprehensive Cancer Center.
Videos by year
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Oncohistones in Disease: From Cancer to...Beyond
Nada Jabado, MD, PhD
McGill University
Chromatin Remodeler Mutations in Cancer: From Mechanisms to Emerging Therapies
Charles W. M. Roberts, MD, PhD
St. Jude Children's Research Hospital
Antagonist Development for Chromodomain-Helicase DNA-Binding Protein 1 (CHD1)
Rebecca Johnson
University of North Carolina at Chapel Hill
Small Molecules inhibitors reveal direct targets of chromatin remodelers
Karen Adelman, PhD
Harvard University
Chemically Targeting Specific Chromatin Remodeling Subcomplexes in Cancer
Emily Dykhuizen, PhD
Purdue University
Acetyl-Click Screening Platform Identifies Small-Molecule and Peptide-based Inhibitors of Histone Acetyltransferase 1 (HAT1)
Joshua Gruber, MD, PhD
UT Southwestern Medical Center
A General Strategy for Drugging Transcription Factors
Anna Mapp, PhD
University of Michigan
Impact of Supraphysiologic MDM2 Expression on P53Independent Chromatin Networks and Therapeutic Responses in Sarcoma
Samantha Bevill, PhD
Dana-Farber Cancer Institute
Targeting RNA Modifying Enzymes in the Treatment of Cancer
Tony Kouzarides, PhD, FMedSci, FRS
University of Cambridge
Anticancer Benzoxaboroles Inhibit Pre-mRNA Processing by Direct Inhibition of CPSF3
Deepak Nijhawan, MD, PhD
UT Southwestern Medical Center
Jun Qi, PhD
Dana-Farber Cancer Institute
Harvard Medical School
Transcription Targeted Therapeutics
Aseem Z. Ansari, PhD
St. Jude Children's Research Hospital
Rewiring Cancer Drivers to Activate Apoptosis
Gerald Crabtree, MD
Stanford University
Targeting the Chromatin-Binding of XPO1 Disrupts NFAT and T Cell Activation
Drew Adams, PhD
Case Western Reserve University School of Medicine
Harnessing Deubiquitinases for Next-Generation Protein Stability Therapeutics
Sara Buhrlage, PhD
Dana-Farber Cancer Institute
Harvard Medical School
Time-Resolved Protein Synthesis Reveals Distinct Phases of Oncogenic Signaling and Identifies the ‘Achilles Heel’ of a Liver Cancer FL-HCC
Gihoon Lee, PhD
Princeton University
Design of New Protein Function Using Deep Learning
David Baker, PhD
University of Washington
In Vivo Dendritic Cells Targeted DNA Vaccination in Combination with Tumor-Selective Chemotherapy Eradicates Established Mouse Melanoma
Arabinda Chaudhuri, PhD
Indian Institute of Science Education and Research Kolkata
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Welcome and Introduction
Charles WM Roberts, MD, PhD
St. Jude Children's Research Hospital
Therapeutic Targeting of Chromatin Complexes in Cancer
Scott Armstrong, MD, PhD
Dana-Farber Cancer Institute
Etiology and Impact of Methylation Changes in Cancer
Bradley Bernstein, MD, PhD
Dana-Farber Cancer Institute
Transcriptional Hubs or Condensates?
Tanja Mittag, PhD
St. Jude Children's Research Hospital
Visualizing Drug-Binding Pockets in Transcription Factors
Fraydoon Rastinejad, PhD
University of Oxford
Modularized Molecule Making
Daniel Blair, PhD
University of Illinois at Urbana-Champaign
The Awesome Power of Synthetic Organic Chemistry in Drug Development
Ray Deshaies, PhD
AmGen, Inc.
Sequence-Based Design of Small Molecules Targeting RNA Structures to Manipulate and Study Disease Biology
Matt Disney, PhD
Scripps Research Institute (Florida)
Protein Dynamics at the Heart of New Cancer Drug Design Approaches
Dorothee Kern, PhD
Brandeis University
Regulation of Liver Energy Balance by Nutrient-sensing Nuclear Receptors
David Moore, PhD
University of California, Berkeley
A Chemist’s Foray into Translational Research
Peter Schultz, PhD
Scripps Research Institute (La Jolla) -
Histone Mutations and Disrupted Development in Pediatric High-Grade Glioma
Suzanne J. Baker, PhD
St. Jude Children's Research Hospital
Recorded: July 22, 2021
Recent Insights into Chromatin Transcription
Patrick Cramer, PhD
Max Planck Institute for Biophysical Chemistry
Recorded: July 22, 2021
NSD2 in Lymphoid Malignancy
Jonathan D. Licht, MD
University of Florida Cancer Center
Recorded: July 22, 2021
Structure and Function of Mammilian SWI/SNF Chromatin Remodeling Complexes in Human Cancer
Cigall Kadoch, PhD
Dana-Farber Cancer Institute
Harvard Medical School
Broad Institute of MIT and Harvard
Recorded: July 22, 2021
Three Possible Paths to Targeting Undruggable Transcripton Factors
William G. Kaelin Jr., MD
Harvard Medical School, Dana-Farber Cancer Institute
Recorded: July 22, 2021
Transcriptional Networks in Tumor-Infliltrating T-cells
Anjana Rao, PhD
LaJolla Institute for Immunology
Recorded: July 22, 2021
Personalization of Transcriptional Therapy with Drugs Targeting Nuclear Receptors
Mitchell A. Lazar, MD, PhD
University of Pennsylvania
Recorded: July 22, 2021
Rationalizing Anti-cancer Drug Responses Using Proteomics and Machine Learning: Towards Next Generation Precision Medicine
Pedro R. Cutillas, PhD
Barts Cancer Institute
Recorded: July 23, 2021
Predictors of response to cancer immunotherapy: Beyond Tumour Mutational Burden
Francesca Ciccarelli, PhD
King's College, London
Recorded July 23, 2021
Using Response Surface Models to Analyze Drug Combinations
Anang A. Shelat, PhD
St. Jude Children's Research Hospital
Recorded: July 23, 2021
Prediction of a Protein's Free Energy Surface with Validation Using Hydrogen/Deuterium Exchange
Tobin R. Sosnick, PhD
University of Chicago
Recorded: July 23, 2021
Computational Enzymology: The Structure, Function and Evolution of Enzymes
Professor Dame Janet Thornton
European Molecular Biology Laboratory
Recorded: July 23, 2021
Variation in GPCR Signaling: Implications for Drug Discovery
M. Madan Babu, PhD, FRSC
St. Jude Children's Research Hospital
Recorded: July 23, 2021
Chemical Control of Gene Expression
James E. Bradner MD
Novartis Institutes for Biomedical Research
Recorded: July 22, 2021
Discovery and Development of GPCR Allosteric Ligands: From Concept to Clinic
Craig W. Lindsley, PhD
Vanderbilt University
Recorded: July 23, 2021
Design, Syntheses and Studies of New Antibiotics
Marvin J. Miller, PhD
University of Notre Dame
Recorded: July 23, 2021 -
Chromatin Remodeler Mutations in Cancer: Mechanisms and Therapeutic Vulnerabilities
Charles Roberts, MD, PhD
St. Jude Children's Research Hospital
Recorded Sept. 24, 2020
Allosteric Antagonists of Methyl-lysine Reader Domain Interactions with DNA/RNA
Stephen Frye, PhD
University of North Carolina, Chapel Hill
Recorded Sept. 24, 2020
Painting Chromatin with Synthetic Protein Chemistry
Tom Muir, PhD
Princeton University
Recorded Sept. 24, 2020
Transcriptional Enhancers and Emergence of Form and Function During Development and Evolution
Joanna Wysocka, PhD
Stanford University
Recorded Sept. 24, 2020
Chemical Control of Gene Expression
Aseem Ansari, PhD
St. Jude Children's Research Hospital
Recorded Sept. 24, 2020
Writing the Rules for Targeting Dynamic Transcriptional Coactivators
Anna Mapp, PhD
University of Michigan
Recorded Sept. 24, 2020
Systematic Targeting of Transcription Factor-Coactivator Protein-Protein Interactions
Dr. Paramjit (Bobby) Arora
New York University
Recorded Sept. 24, 2020
Targeted Protein Degradation - A New Therapeutic Strategy
Nathanael Gray, PhD
Stanford University
Recorded Sept. 24, 2020
Attenuating Oncogenic Transcription with Small Molecules
Angela Koehler, PhD
Massachusetts Institute of Technology
Recorded Sept. 25, 2020
Chemical Transcription Modulators of Promiscuous Xenobiotic Receptors
Taosheng Chen, PhD, PMP
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Targeted Protein Degradation Platform
Zoran Rankovic, PhD
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Nuclear Condensates in Gene Regulation, Disease Pathology and Drug Partitioning
Rick Young, PhD
Massachusetts Institute of Technology
Recorded Sept. 24, 2020
Bromodomain-Selective BETi as Pediatric Anticancer Agents
Anang Shelat, PhD
Philip Potter, PhD
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Bridge Over Troubled Water Networks – Binding and Garfunkel
Marcus Fischer, PhD
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Network Models in Biology: From Molecular Machinery to Chromosomal Dynamics, to Systems Pharmacology
Ivet Bahar, PhD
University of Pittsburgh
Recorded Sept. 25, 2020
History and Future of Thalidomide Analogs in Human Health
Phil Chamberlain, PhD
Neomorph, Inc.
Recorded Sept. 25, 2020
Videos by Topic
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Histone Mutations and Disrupted Development in Pediatric High-Grade Glioma
Suzanne J. Baker, PhD
St. Jude Children's Research Hospital
Recorded: July 22, 2021
Recent Insights into Chromatin Transcription
Patrick Cramer, PhD
Max Planck Institute for Biophysical Chemistry
Recorded: July 22, 2021
NSD2 in Lymphoid Malignancy
Jonathan D. Licht, MD
University of Florida Cancer Center
Recorded: July 22, 2021
Structure and Function of Mammilian SWI/SNF Chromatin Remodeling Complexes in Human Cancer
Cigall Kadoch, PhD
Dana-Farber Cancer Institute
Harvard Medical School
Broad Institute of MIT and Harvard
Recorded: July 22, 2021
Chromatin Remodeler Mutations in Cancer: Mechanisms and Therapeutic Vulnerabilities
Charles Roberts, MD, PhD
St. Jude Children's Research Hospital
Recorded Sept. 24, 2020
Allosteric Antagonists of Methyl-lysine Reader Domain Interactions with DNA/RNA
Stephen Frye, PhD
University of North Carolina, Chapel Hill
Recorded Sept. 24, 2020
Painting Chromatin with Synthetic Protein Chemistry
Tom Muir, PhD
Princeton University
Recorded Sept. 24, 2020
Transcriptional Enhancers and Emergence of Form and Function During Development and Evolution
Joanna Wysocka, PhD
Stanford University
Recorded Sept. 24, 2020 -
Three Possible Paths to Targeting Undruggable Transcripton Factors
William G. Kaelin Jr., MD
Harvard Medical School, Dana-Farber Cancer Institute
Recorded: July 22, 2021
Transcriptional Networks in Tumor-Infliltrating T-cells
Anjana Rao, PhD
LaJolla Institute for Immunology
Recorded: July 22, 2021
Personalization of Transcriptional Therapy with Drugs Targeting Nuclear Receptors
Mitchell A. Lazar, MD, PhD
University of Pennsylvania
Recorded: July 22, 2021
Chemical Control of Gene Expression
Aseem Ansari, PhD
St. Jude Children's Research Hospital
Recorded Sept. 24, 2020
Writing the Rules for Targeting Dynamic Transcriptional Coactivators
Anna Mapp, PhD
University of Michigan
Recorded Sept. 24, 2020
Systematic Targeting of Transcription Factor-Coactivator Protein-Protein Interactions
Dr. Paramjit (Bobby) Arora
New York University
Recorded Sept. 24, 2020
Targeted Protein Degradation - A New Therapeutic Strategy
Nathanael Gray, PhD
Stanford University
Recorded Sept. 24, 2020
Attenuating Oncogenic Transcription with Small Molecules
Angela Koehler, PhD
Massachusetts Institute of Technology
Recorded Sept. 25, 2020
Chemical Transcription Modulators of Promiscuous Xenobiotic Receptors
Taosheng Chen, PhD, PMP
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Targeted Protein Degradation Platform
Zoran Rankovic, PhD
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Nuclear Condensates in Gene Regulation, Disease Pathology and Drug Partitioning
Rick Young, PhD
Massachusetts Institute of Technology
Recorded Sept. 24, 2020 -
Rationalizing Anti-cancer Drug Responses Using Proteomics and Machine Learning: Towards Next Generation Precision Medicine
Pedro R. Cutillas, PhD
Barts Cancer Institute
Recorded: July 23, 2021
Predictors of response to cancer immunotherapy: Beyond Tumour Mutational Burden
Francesca Ciccarelli, PhD
King's College, London
Recorded July 23, 2021
Using Response Surface Models to Analyze Drug Combinations
Anang A. Shelat, PhD
St. Jude Children's Research Hospital
Recorded: July 23, 2021
Prediction of a Protein's Free Energy Surface with Validation Using Hydrogen/Deuterium Exchange
Tobin R. Sosnick, PhD
University of Chicago
Recorded: July 23, 2021
Computational Enzymology: The Structure, Function and Evolution of Enzymes
Professor Dame Janet Thornton
European Molecular Biology Laboratory
Recorded: July 23, 2021
Variation in GPCR Signaling: Implications for Drug Discovery
M. Madan Babu, PhD, FRSC
St. Jude Children's Research Hospital
Recorded: July 23, 2021
Bromodomain-Selective BETi as Pediatric Anticancer Agents
Anang Shelat, PhD
Philip Potter, PhD
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020 -
Chemical Control of Gene Expression
James E. Bradner MD
Novartis Institutes for Biomedical Research
Recorded: July 22, 2021
Discovery and Development of GPCR Allosteric Ligands: From Concept to Clinic
Craig W. Lindsley, PhD
Vanderbilt University
Recorded: July 23, 2021
Design, Syntheses and Studies of New Antibiotics
Marvin J. Miller, PhD
University of Notre Dame
Recorded: July 23, 2021
Bridge Over Troubled Water Networks – Binding and Garfunkel
Marcus Fischer, PhD
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Network Models in Biology: From Molecular Machinery to Chromosomal Dynamics, to Systems Pharmacology
Ivet Bahar, PhD
University of Pittsburgh
Recorded Sept. 25, 2020
History and Future of Thalidomide Analogs in Human Health
Phil Chamberlain, PhD
Neomorph, Inc.
Recorded Sept. 25, 2020
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