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The Science of Childhood Cancer

Spring 2022 virtual lecture series


The Science of Childhood Cancer is an interactive, weekly lecture series designed to engage the scientific community on key questions in pediatric cancer research. The Spring 2022 season of this series, hosted by the St. Jude Comprehensive Cancer Center, will be announced soon.

Invited speakers are leading experts across the spectrum of basic, translational, clinical and population science. Two Rising Stars of Cancer Research lectures in the 15-week series will feature thematically related talks by early- to mid-career investigators conducting exciting and innovative work in the field.

Seminars will occur each Thursday from 12 pm – 1 pm Central time / 1 pm – 2 pm Eastern time. Available recordings will be posted here in the week following the live event.


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  • Charles W. M. Roberts, MD, PhD

    Charles W. M. Roberts, MD, PhD


    Member, St. Jude Faculty

    • Executive Vice President
    • Director, Comprehensive Cancer Center
    • Director, Molecular Oncology Division
  • Charles G. Mullighan, MBBS (Hons), MSc, MD

    Charles G. Mullighan, MBBS (Hons), MSc, MD


    Member, St. Jude Faculty

    • Deputy Director, Comprehensive Cancer Center
    • Co-Leader, Hematological Malignancies Program
    • Medical Director, St. Jude Biorepository

Upcoming Lectures

Lectures for the Spring 2022 lecture series will be announced soon. Please sign up for updates to receive notifications about the speaker line up.


Prior Lectures

  1. Charles Mullighan portrait

    Deconvoluting the Origins of Acute Leukemia

    Charles G. Mullighan, MBBS (Hons), MSc, MD
    Member, Pathology
    Deputy Director, Comprehensive Cancer Center
    St. Jude Children’s Research Hospital

    Watch the lecture


    Meredith Irwin portrait

    Identification of Biomarkers, Models and Targets to Improve Outcomes and Precision Approaches for Neuroblastoma

    Meredith Irwin, MD
    The Hospital for Sick Children
    Chair, Department of Paediatrics; Professor, Departments of Paediatrics; Medical Biophysics; Laboratory Medicine & Pathobiology
    University of Toronto

    Watch the lecture


    Olivier Delattre portrait

    Modulation of the Activity of the Dominant Oncogene EWS-FLI1 by Germline Polymorphisms and Cohesin Mutations

    Olivier Delattre, MD, PhD
    Inserm Research Director
    Head of Cancer, Heterogeneity, Instability and Plasticity Department
    Head of the Pediatric Oncology Center
    Institut Curie, Paris, France

    Watch the lecture


    Melissa Hudson  portrait

    The Role of Survivorship Research in Advancing Childhood Cancer Care and Quality of Survival

    Melissa M. Hudson, MD
    Director, Cancer Survivorship Division
    St. Jude Children’s Research Hospital

    Watch the lecture


    Dan Landau portrait

    Deciphering Somatic Evolution with Single-Cell Multi-Omics

    Dan A. Landau, MD, PhD
    Associate Professor of Medicine, Division of Hematology and Medical Oncology
    Associate Professor of Physiology and Biophysics
    Weill Cornell Medical College
    Core Member
    New York Genome Center

    Lecture not archived.


    David Teachey  portrait

    The Biology, Diagnosis, and Management of T-Cell Acute Lymphoblastic Leukemia and Lymphoma

    David T. Teachey, MD
    Associate Professor of Pediatrics
    Division of Oncology
    The Children’s Hospital of Philadelphia
    University of Pennsylvania
    Perelman School of Medicine

    Watch the lecture


    David Fisher portrait

    Sunlight and Skin: Lessons for Melanoma Therapeutics From Its Unique Pathogenesis

    David E. Fisher, MD, PhD
    Professor of Dermatology and Pediatrics
    Chair, Dept of Dermatology
    Mass General Hospital & Harvard Medical School

    Watch the lecture


    Matt Vander Heiden portrait

    Influence of Metabolism on Cancer Progression

    Matt Vander Heiden, MD, PhD
    Director, Koch Institute
    Lester Wolfe Professor in Molecular Biology
    Koch Institute for Integrative Cancer Research at MIT

    Watch the lecture


    photo of Bradley Bernstein

    Epigenetic Mechanisms of Tumorigenesis

    Bradley Bernstein, MD, PhD
    Chair, Department of Cancer Biology
    Dana-Farber Cancer Institute
    Institute Member
    Broad Institute of Harvard and MIT

    Watch the lecture


    Rising Stars of Cancer Research

    Photo of Saar Gill

    Chimeric Antigen Receptor-Redirected Macrophages for the Treatment of Solid Tumors

    Saar Gill, MBBS, PhD, FRACP
    Associate Professor of Medicine
    Scientific Co-Director, Cell Therapy and Transplantation
    University of Pennsylvania Perelman School of Medicine

    Watch the lecture


    Rising Stars of Cancer Research

    photo of Yvonne Chen

    Engineering Next-Generation CAR-T Cells for Cancer Immunotherapy

    Yvonne Y. Chen, PhD
    Associate Professor of Microbiology, Immunology & Molecular Genetics
    University of California, Los Angeles

    Lecture not archived.


    Mignon Loh portrait

    What Will it Take To Cure Every Child with Acute Lymphoblastic Leukemia?

    Mignon Loh, MD
    Professor of Pediatrics
    Benioff Chair of Children’s Health
    Deborah and Arthur Ablin Endowed Professor of Pediatric Molecular Oncology
    Chair, ALL Committee, Children’s Oncology Group
    Benioff Children’s Hospital, UCSF, San Francisco, CA

    Watch the lecture


    Martin Pule Heiden portrait

    CAR T Cell Therapies for Childhood Cancer, the University College London Experience

    Martin Pule, MB, FRCPath
    Senior Lecturer in Haematology
    University College London

    Watch the lecture


    Kirsten Ness portrait

    Interventions to Prevent or Remediate Frailty in Childhood Cancer Survivors

    Kirsten K. Ness, PT, PhD, FAPTA
    Member, Epidemiology and Cancer Control
    St. Jude Children’s Research Hospital

    Watch the lecture


    Rising Stars of Cancer Research

    Giles Robinson portrait

    Tailoring Medulloblastoma Therapy to Fit the Evolving Molecular Landscape

    Giles Robinson, MD
    Associate Member, Oncology Department
    St. Jude Children’s Research Hospital

    Watch the lecture


    Rising Stars of Cancer Research

    Mariella Filbin portrait

    Developmental Pathways, Plasticity and Novel Treatment Opportunities in Pediatric High-Grade Brain Tumors

    Mariella Filbin, MD, PhD
    Attending Physician in Pediatric Hematology/Oncology
    Assistant Professor of Pediatrics, Harvard Medical School
    Co-Director for Research, Pediatric Neuro-Oncology Program
    Dana-Farber Cancer Institute
    Boston Children’s Cancer and Blood Disorder Center

    Lecture not archived.


    Doug Green portrait

    Persister Act: Near-Death Experiences in Cancer Cells

    Douglas R. Green, PhD
    Chair, Immunology Department
    Co-Leader, Cancer Biology Program
    Peter C. Doherty Endowed Chair of Immunology
    St. Jude Children's Research Hospital

    Lecture not yet archived.

  2. Jinghui Zhang portrait

    Genomic Variants in Pediatric Cancer: Landscape, Precision Oncology, and Data Sharing Ecosystem

    Jinghui Zhang, PhD
    Chair, Department of Computational Biology
    St. Jude Endowed Chair in Bioinformatics
    St. Jude Children’s Research Hospital
    Original lecture date: January 28

    Watch lecture


    Richard Gilbertson portrait

    Will We Ever Cure Cancer?

    Richard Gilbertson, MD, PhD
    Li Ka Shing Chair of Oncology
    Head, Department of Oncology
    Director, Cancer Research UK Major Centre 
    University of Cambridge, England
    Original lecture date: February 4

    Watch lecture


    Scott Armstrong portrait

    Chromatin Complexes as Therapeutic Opportunities in Cancer

    Scott Armstrong, MD, PhD
    President, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center
    Chair, Department of Pediatric Oncology
    Dana-Farber Cancer Institute
    David G. Nathan Professor of Pediatrics
    Harvard Medical School
    Original lecture date: February 11

    Watch lecture


    Robin Yabroff portrait

    Financial Hardship After Childhood Cancer

    Robin Yabroff, PhD, MBA
    Scientific Vice President, Health Services Research
    American Cancer Society
    Original lecture date: February 18

    Watch lecture


    John Crispino portrait

    Mechanisms of Leukemogenesis in Children with Down Syndrome

    John Crispino, PhD, MBA
    Director, Division of Experimental Hematology
    The Wall Street Committee Endowed Chair
    Department of Hematology
    St. Jude Children’s Research Hospital
    Original lecture date: February 25

    Watch lecture


    Sheila Singh portrait

    Therapeutic Targeting of Self-Renewal of Medulloblastoma Stem Cells: Strategies for Blocking Recurrence

    Sheila Singh, MD, PhD, FRCS(C)
    Pediatric Neurosurgeon, McMaster Children's Hospital
    Professor of Surgery, McMaster University
    Principal Investigator, Stem Cell and Cancer Research Institute, McMaster University
    Senior Canada Research Chair in Human Cancer Stem Cell Biology
    University Scholar, Chair, McMaster College of Health Inventors
    Original lecture date: March 4

    Watch lecture


    Jinghui Zhang portrait

    Single Cell Atlases as Roadmaps in Pediatric Cancer

    Aviv Regev, PhD
    Head of Research and Early Development
    Original lecture date: March 11

    Watch lecture


    Douglas Hawkins portrait

    Successes and Challenges in Pediatric Cancer: The COG Perspective

    Douglas S. Hawkins, MD
    Chair of Children's Oncology Group
    Professor of Pediatrics
    University of Washington School of Medicine
    Seattle Children’s Hospital
    Original lecture date: March 18

    Watch lecture


    David T.W. Jones portrait

    Pediatric High-grade Glioma – Novel Drivers Define a Spectrum of New Tumor Subgroups

    David T.W. Jones, PhD
    Group Leader, 'Pediatric Glioma Research'
    Hopp Children’s Cancer Center (KiTZ)
    German Cancer Research Center (DKFZ)
    Original lecture date: March 25

    Watch lecture


    Karen Vousden portrait

    A Role for Metabolism in Cancer Development and Progression

    Karen Vousden, PhD
    Senior Group Leader
    The Francis Crick Institute
    Original lecture date: April 1

    Lecture not archived


    Anne Kirchhoff portrait

    Identifying Strategies to Improve HPV Vaccination Among Childhood Cancer Survivors

    Anne Kirchhoff, PhD, MPH
    Associate Professor, Pediatrics
    University of Utah/Huntsman Cancer Institute
    Original lecture date: April 8

    Watch lecture


    Madan Babu portrait

    Data Science Approaches to GPCR Signaling and Personalized Medicine

    Madan Babu, PhD, FRSC
    Endowed Chair in Biological Data Science
    Director, Center of Excellence for Data Driven Discovery
    Department of Structural Biology
    St. Jude Children’s Research Hospital
    Original lecture date: April 15

    Watch lecture


    Zhaoming Wang portrait

    Genetic and Epigenetic Approaches Towards Understanding Risk of Chronic Health Conditions Among Survivors of Childhood Cancer

    Zhaoming Wang, PhD
    Department of Epidemiology and Cancer Control
    Department of Computational Biology
    St. Jude Children’s Research Hospital
    Original lecture date: April 22

    Watch lecture


    Kimberly Stegmaier portrait

    A First-generation Pediatric Cancer Dependency Map

    Kimberly Stegmaier, MD
    Professor of Pediatrics, Harvard Medical School
    Ted Williams Chair and Vice Chair of Pediatric Oncology Research, Dana-Farber Cancer Institute
    Institute Member, Broad Institute of Harvard and MIT
    Original lecture date: April 29, 2021

    Watch lecture


    Cigall Kadoch portrait

    Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Cancer

    Cigall Kadoch, PhD
    Associate Professor, Department of Pediatric Oncology
    Dana-Farber Cancer Institute and Harvard Medical School
    Institute Member and Epigenomics Program Co-Director, Broad Institute
    Original lecture date: May 6, 2021

    Watch lecture

  3. Michel Sadelain portrait

    CAR T Cells: On the Road to Synthetic Immunity

    Michel Sadelain, MD, PhD
    Director, Center for Cell Engineering
    Stephen and Barbara Friedman Chair
    Member, Immunology Program
    Member, Departments of Medicine and Pediatrics
    Memorial Sloan-Kettering Cancer Center
    Original lecture date: August 13

    Watch lecture


    Charles W.M. Roberts portrait

    Chromatin Remodeler Mutations in Cancer: Mechanisms and Therapeutic Vulnerabilities

    Charles W.M. Roberts, MD, PhD
    Member, St. Jude Faculty
    Executive Vice President
    Director, Comprehensive Cancer Center
    Director, Division of Molecular Oncology
    Department of Oncology
    St. Jude Children's Research Hospital
    Original lecture date: August 20

    Watch lecture


    Terry Fry portrait

    The Future of CAR T Cells for Hematologic Malignancies: Beyond Antigen Targeting

    Terry J. Fry, MD
    Professor of Pediatrics, Hematology and Immunology
    Co-Director, Human Immunology and Immunotherapy Initiative and Director of Cancer Immunotherapy
    University of Colorado School of Medicine
    Robert and Kathleen Clark Endowed Chair in Pediatric Cancer Therapeutics
    Children’s Hospital Colorado, Center for Cancer and Blood Disorders
    Original lecture date: August 27

    Watch lecture


    Richard Kriwacki portrait

    Phase Separation in Gene Transcription: From the Nucleolus to Aberrant Transcription in Leukemia

    Richard W. Kriwacki, PhD
    Co-Leader, Cancer Biology Program
    Department of Structural Biology
    St. Jude Children's Research Hospital
    Original lecture date: September 3

    Watch lecture


    Smita Bhatia portrait

    Late Effects Among Survivors of Blood or Marrow Transplantation

    Smita Bhatia, MD, MPH
    Director, Institute for Cancer Outcomes and Survivorship
    Gay and Bew White Endowed Chair in Pediatric Oncology
    Professor and Vice Chair, Dept. of Pediatrics
    School of Medicine, University of Alabama at Birmingham
    Original lecture date: September 10

    Watch lecture


    Christine Brown portrait

    Advancing CAR T Cells for the Treatment of Glioblastoma: Progress and Challenges

    Christine Brown, PhD
    Heritage Provider Network Professor of Immunotherapy
    Deputy Director, T Cell Therapeutics Research Laboratory
    City of Hope
    Original lecture date: September 17

    Lecture not archived.


    Kevin Krull portrait

    Cognitive Outcomes of Childhood Cancer: Neurophysiology, Biomarkers and Interventions

    Kevin R. Krull, PhD
    Endowed Chair, Cancer Survivorship
    Faculty Member, Departments of Epidemiology and Cancer Control, and Psychology
    St. Jude Children's Research Hospital
    Original lecture date: September 24

    Watch lecture


    Ioannis Aifantis portrait

    3D Chromosomal Organization in Pediatric Leukemia: Impact for Drug Response and Disease Progression

    Iannis Aifantis, PhD
    Professor and Chair
    Department of Pathology and Perlmutter Cancer Center
    NYU Grossman School of Medicine
    Original lecture date: October 1

    Watch lecture


    Paul Northcott portrait

    Medulloblastomics 2020: Biological & Clinical Insights From 1,000s of Patients

    Paul A. Northcott, PhD
    Associate Faculty Member, Department of Developmental Neurobiology
    Division of Brain Tumor Research
    St. Jude Children's Research Hospital
    Original lecture date: October 8

    Watch lecture


    Crystal Mackall portrait

    CAR T Cells for Pediatric Cancers: Progress and Challenges

    Crystal Mackall, MD
    Ernest and Amelia Gallo Family Professor of Pediatrics and Internal Medicine
    Founding Director, Stanford Center for Cancer Cell Therapy
    Director, Parker Institute for Cancer Immunotherapy at Stanford
    Associate Director, Stanford Cancer Institute
    Leader, Cancer Immunology and Immunotherapy Program
    Director, Cancer Immunotherapy Program
    Department of Pediatrics - Hematology & Oncology
    Department of Medicine - Blood & Marrow Transplantation
    Stanford University
    Original lecture date: October 15

    Watch lecture


    Richard Young portrait
    Isaac Klein portrait

    Partitioning of Cancer Therapeutics in Nuclear Condensates

    Richard A. Young, PhD
    Professor, Department of Biology
    Member, Whitehead Institute
    Massachusetts Institute of Technology (MIT)

    Isaac A. Klein, MD, PhD
    Dana-Farber Cancer Institute
    Whitehead Institute
    Original lecture date: October 22

    Watch lecture


    Rani George portrait

    Harnessing Lineage Plasticity for the Treatment of Neuroblastoma

    Rani George, MD, PhD
    Associate Professor of Pediatrics, Harvard Medical School
    Dept. of Pediatric Hematology/Oncology
    Dana-Farber Cancer Institute/Boston Children's Hospital
    Original lecture date: October 29

    Watch lecture


    Paul Thomas portrait

    Organized Destruction and Destructive Organization: The Diversity of Immune Responses Towards Tumors and Pathogens

    Paul G. Thomas, PhD
    Faculty Member, Department of Immunology
    St. Jude Children's Research Hospital
    Original lecture date: November 5

    Watch lecture


    Michelle Monje portrait

    Targeting Neuron-Glial Interactions in Childhood Brain Cancer

    Michelle Monje, MD, PhD
    Associate Professor, Neurology & Neurological Sciences
    Stanford University
    Original lecture date: November 12

    Watch lecture


    Eric Chow portrait

    Emerging Late Effects of Targeted Molecular Therapies

    Eric Chow, MD, MPH
    Associate Professor, Clinical Research Division
    Associate Professor, Public Health Sciences Division
    Director, Prevention Center Shared Resource
    Fred Hutchinson Cancer Research Center
    Medical Director, Cancer Survivorship Program
    Seattle Children's Hospital
    Associate Professor, Pediatrics
    University of Washington
    Original lecture date: November 19

    Watch lecture


Comprehensive Cancer Center

St. Jude is the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children.