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The Science of Childhood Cancer

A 15-week virtual lecture series

 
 

The Science of Childhood Cancer is an interactive, weekly lecture series designed to engage the scientific community on key questions in pediatric cancer research. Invited speakers are leading experts across the spectrum of basic, translational, clinical and population science.

A new 15-week season will launch in fall 2022, hosted by the St. Jude Comprehensive Cancer Center. Register to receive updates and an announcement when the new speaker lineup is released, and browse archive lectures from previous speakers.

View archived lectures

 
 

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Hosts

 
 

Prior Lectures

  1. photo of Charalampos Kalodimos
     

    The Conformational Landscape of Protein Kinases in Physiology and Disease

    Charalampos Kalodimos, PhD
    Member, St. Jude Faculty
    Chair, Structural Biology Department
    Joseph Simone Endowed Chair in Basic Research
    St. Jude Children's Research Hospital

    Watch the Lecture

     
     

    photo of Lindsay Morton
     

    Genetic Susceptibility to Subsequent Neoplasms Following Childhood Cancer

    Lindsay M. Morton, PhD
    Senior Investigator & Deputy Branch Chief, Radiation Epidemiology Branch
    Head, Cancer Survivorship Research Unit
    Division of Cancer Epidemiology and Genetics, National Cancer Institute 

    Watch the Lecture

     
     

    photo of Jun J. Yang
     

    Unraveling the Heterogeneity of Acute Lymphoblastic Leukemia Through the Lens of Pharmacogenomics

    Jun J. Yang, PhD
    Member and Vice Chair, Division of Pharmaceutical Sciences
    Department of Pharmacy and Pharmaceutical Sciences
    St. Jude Children's Research Hospital

    Watch the Lecture

     
     

    photo of David Chen
     

    Identify Novel Therapeutic Opportunities in Pediatric Cancers Using High-Resolution CRISPR Tiling Scans

    David Chen, PhD
    Associate Professor, Systems Biology , City of Hope Cancer Center

    Watch the Lecture

     
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    photo of Liling Wan
     

    Reading Epigenetic Landscape: New Mechanisms and Therapeutic Opportunities

    Liling Wan, PhD
    Assistant Professor, Department of Cancer Biology
    Penn Epigenetics Institute
    Perelman School of Medicine, University of Pennsylvania

    Lecture not recorded

     
     

    photo of Suzanne Baker
     

    Disrupted Development in Pediatric High-Grade Glioma

    Suzanne J. Baker, PhD
    St. Jude Children's Research Hospital

    Lecture not recorded

     
     

    photo of Yutaka Yasui
     

    What Can We Learn From GWAS Data?  Genetic Heterogeneity and Rare Variant Hypothesis of Cancer Risk

    Yutaka Yasui, PhD
    Member, Epidemiology and Cancer Control
    St. Jude Children's Research Hospital

    Watch the Lecture

     
     

    photo of Alejandro Gutierrez
     

    Pathobiology of asparaginase resistance

    Alejandro Gutierrez, MD
    Associate Professor of Pediatrics, Boston Children’s Hospital
    Dana-Farber Cancer Institute.

    Lecture not recorded

     
     

    photo of Katherine Janeway
     

    Learning From Children: Designing Better Clinical Trials with Their Data

    Katherine A. Janeway, MD, MMSc
    Associate Professor of Pediatrics, Harvard Medical School
    Senior Physician, Dana-Farber / Boston Children's Cancer and Blood Disorders Center
    Director, Clinical Genomics, Dana-Farber Cancer Institute

     
     

    photo of Jiyang Yu
     

    Targeting Hidden Drivers Toward Precision Oncology

    Jiyang Yu, PhD
    Associate Member
    Department of Computational Biology
    St. Jude Children's Research Hospital

     
     

    photo of Stefan Pfister
     

    Mapping Childhood Brain Tumor Profiles Onto Normal Development Identifies Novel Therapeutic Vulnerabilities

    Prof. Dr. Stefan M. Pfister
    Director Preclinical Program, Hopp Children's Cancer Center Heidelberg (KiTZ)
    Head, Division of Pediatric Neurooncology, DKFZ
    Deputy Head, KiTZ Clinical Trial Unit (ZIPO) and Pediatric Brain Tumors, Heidelberg University Hospital

     
     

    photo of Hongbo Chi
     

    Functional Genomics of T-Cell Metabolism and Immuno-oncology

    Hongbo Chi, PhD
    Member and Robert G. Webster Endowed Chair in Immunology, St. Jude Children's Research Hospital

    Watch the Lecture

     
     

    photo of Yaël Mossé, MD
     

    Discovering and Targeting Neuroblastoma Vulnerabilities: ALK Inhibition as a Paradigm

    Yaël Mossé, MD
    Children's Hospital of Philadelphia

     
     

    photo of Ralph DeBerardninis
     

    Human Metabolic Outliers

    Ralph J. DeBerardinis, MD, PhD
    HHMI Investigator and Professor
    Children’s Medical Center Research Institute at UT Southwestern

    Lecture not archived

     
     

    photo of Akiko Shimamura
     

    Clonal Evolution and Somatic Reversion in Genetic Predisposition to TP53-Mutated MDS

    Akiko Shimamura, MD, PhD
    Professor of Pediatrics, Harvard Medical School
    Samuel E. Lux IV Chair in Hematology Oncology
    Director, Bone Marrow Failure and MDS Program
    Dana Farber/Boston Children’s Cancer and Blood Disorders Center

     
     

    image of Kevfin Oeffinger
     

    Secondary Breast Cancer: A Paradigm for Survivorship Research

    Kevin Oeffinger, MD
    Director
    DCI Center for Onco-Primary Care
    Duke University

     
     
  2. Charles Mullighan portrait
     

    Deconvoluting the Origins of Acute Leukemia

    Charles G. Mullighan, MBBS (Hons), MSc, MD
    Member, Pathology
    Deputy Director, Comprehensive Cancer Center
    St. Jude Children’s Research Hospital

    Watch the lecture

     
     

    Meredith Irwin portrait
     

    Identification of Biomarkers, Models and Targets to Improve Outcomes and Precision Approaches for Neuroblastoma

    Meredith Irwin, MD
    Paediatrician-in-Chief
    The Hospital for Sick Children
    Chair, Department of Paediatrics; Professor, Departments of Paediatrics; Medical Biophysics; Laboratory Medicine & Pathobiology
    University of Toronto

    Watch the lecture

     
     

    Olivier Delattre portrait
     

    Modulation of the Activity of the Dominant Oncogene EWS-FLI1 by Germline Polymorphisms and Cohesin Mutations

    Olivier Delattre, MD, PhD
    Inserm Research Director
    Head of Cancer, Heterogeneity, Instability and Plasticity Department
    Head of the Pediatric Oncology Center
    Institut Curie, Paris, France

    Watch the lecture

     
     

    Melissa Hudson  portrait
     

    The Role of Survivorship Research in Advancing Childhood Cancer Care and Quality of Survival

    Melissa M. Hudson, MD
    Director, Cancer Survivorship Division
    St. Jude Children’s Research Hospital

    Watch the lecture

     
     

    Dan Landau portrait
     

    Deciphering Somatic Evolution with Single-Cell Multi-Omics

    Dan A. Landau, MD, PhD
    Associate Professor of Medicine, Division of Hematology and Medical Oncology
    Associate Professor of Physiology and Biophysics
    Weill Cornell Medical College
    Core Member
    New York Genome Center

    Lecture not archived.

     
     

    David Teachey  portrait
     

    The Biology, Diagnosis, and Management of T-Cell Acute Lymphoblastic Leukemia and Lymphoma

    David T. Teachey, MD
    Associate Professor of Pediatrics
    Division of Oncology
    The Children’s Hospital of Philadelphia
    University of Pennsylvania
    Perelman School of Medicine

    Watch the lecture

     
     

    David Fisher portrait
     

    Sunlight and Skin: Lessons for Melanoma Therapeutics From Its Unique Pathogenesis

    David E. Fisher, MD, PhD
    Professor of Dermatology and Pediatrics
    Chair, Dept of Dermatology
    Mass General Hospital & Harvard Medical School

    Watch the lecture

     
     

    Matt Vander Heiden portrait
     

    Influence of Metabolism on Cancer Progression

    Matt Vander Heiden, MD, PhD
    Director, Koch Institute
    Lester Wolfe Professor in Molecular Biology
    Koch Institute for Integrative Cancer Research at MIT

    Watch the lecture

     
     

    photo of Bradley Bernstein
     

    Epigenetic Mechanisms of Tumorigenesis

    Bradley Bernstein, MD, PhD
    Chair, Department of Cancer Biology
    Dana-Farber Cancer Institute
    Institute Member
    Broad Institute of Harvard and MIT

    Watch the lecture

     
     

    Rising Stars of Cancer Research

     
    Photo of Saar Gill
     

    Chimeric Antigen Receptor-Redirected Macrophages for the Treatment of Solid Tumors

    Saar Gill, MBBS, PhD, FRACP
    Associate Professor of Medicine
    Scientific Co-Director, Cell Therapy and Transplantation
    University of Pennsylvania Perelman School of Medicine

    Watch the lecture

     
     

    Rising Stars of Cancer Research

     
    photo of Yvonne Chen
     

    Engineering Next-Generation CAR-T Cells for Cancer Immunotherapy

    Yvonne Y. Chen, PhD
    Associate Professor of Microbiology, Immunology & Molecular Genetics
    University of California, Los Angeles

    Lecture not archived.

     
     

    Mignon Loh portrait
     

    What Will it Take To Cure Every Child with Acute Lymphoblastic Leukemia?

    Mignon Loh, MD
    Professor of Pediatrics
    Benioff Chair of Children’s Health
    Deborah and Arthur Ablin Endowed Professor of Pediatric Molecular Oncology
    Chair, ALL Committee, Children’s Oncology Group
    Benioff Children’s Hospital, UCSF, San Francisco, CA

    Watch the lecture

     
     

    Martin Pule Heiden portrait
     

    CAR T Cell Therapies for Childhood Cancer, the University College London Experience

    Martin Pule, MB, FRCPath
    Senior Lecturer in Haematology
    University College London

    Watch the lecture

     
     

    Kirsten Ness portrait
     

    Interventions to Prevent or Remediate Frailty in Childhood Cancer Survivors

    Kirsten K. Ness, PT, PhD, FAPTA
    Member, Epidemiology and Cancer Control
    St. Jude Children’s Research Hospital

    Watch the lecture

     
     

    Rising Stars of Cancer Research

     
    Giles Robinson portrait
     

    Tailoring Medulloblastoma Therapy to Fit the Evolving Molecular Landscape

    Giles Robinson, MD
    Associate Member, Oncology Department
    St. Jude Children’s Research Hospital

    Watch the lecture

     
     

    Rising Stars of Cancer Research

     
    Mariella Filbin portrait
     

    Developmental Pathways, Plasticity and Novel Treatment Opportunities in Pediatric High-Grade Brain Tumors

    Mariella Filbin, MD, PhD
    Attending Physician in Pediatric Hematology/Oncology
    Assistant Professor of Pediatrics, Harvard Medical School
    Co-Director for Research, Pediatric Neuro-Oncology Program
    Dana-Farber Cancer Institute
    Boston Children’s Cancer and Blood Disorder Center

    Lecture not archived.

     
     

    Doug Green portrait
     

    Persister Act: Near-Death Experiences in Cancer Cells

    Douglas R. Green, PhD
    Chair, Immunology Department
    Co-Leader, Cancer Biology Program
    Peter C. Doherty Endowed Chair of Immunology
    St. Jude Children's Research Hospital

    Lecture not yet archived.

     
     
  3. Jinghui Zhang portrait
     

    Genomic Variants in Pediatric Cancer: Landscape, Precision Oncology, and Data Sharing Ecosystem

    Jinghui Zhang, PhD
    Chair, Department of Computational Biology
    St. Jude Endowed Chair in Bioinformatics
    St. Jude Children’s Research Hospital
    Original lecture date: January 28

    Watch lecture

     
     

    Richard Gilbertson portrait
     

    Will We Ever Cure Cancer?

    Richard Gilbertson, MD, PhD
    Li Ka Shing Chair of Oncology
    Head, Department of Oncology
    Director, Cancer Research UK Major Centre 
    University of Cambridge, England
    Original lecture date: February 4

    Watch lecture

     
     

    Scott Armstrong portrait
     

    Chromatin Complexes as Therapeutic Opportunities in Cancer

    Scott Armstrong, MD, PhD
    President, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center
    Chair, Department of Pediatric Oncology
    Dana-Farber Cancer Institute
    David G. Nathan Professor of Pediatrics
    Harvard Medical School
    Original lecture date: February 11

    Watch lecture

     
     

    Robin Yabroff portrait
     

    Financial Hardship After Childhood Cancer

    Robin Yabroff, PhD, MBA
    Scientific Vice President, Health Services Research
    American Cancer Society
    Original lecture date: February 18

    Watch lecture

     
     

    John Crispino portrait
     

    Mechanisms of Leukemogenesis in Children with Down Syndrome

    John Crispino, PhD, MBA
    Director, Division of Experimental Hematology
    The Wall Street Committee Endowed Chair
    Department of Hematology
    St. Jude Children’s Research Hospital
    Original lecture date: February 25

    Watch lecture

     
     

    Sheila Singh portrait
     

    Therapeutic Targeting of Self-Renewal of Medulloblastoma Stem Cells: Strategies for Blocking Recurrence

    Sheila Singh, MD, PhD, FRCS(C)
    Pediatric Neurosurgeon, McMaster Children's Hospital
    Professor of Surgery, McMaster University
    Principal Investigator, Stem Cell and Cancer Research Institute, McMaster University
    Senior Canada Research Chair in Human Cancer Stem Cell Biology
    University Scholar, Chair, McMaster College of Health Inventors
    Original lecture date: March 4

    Watch lecture

     
     

    Jinghui Zhang portrait
     

    Single Cell Atlases as Roadmaps in Pediatric Cancer

    Aviv Regev, PhD
    Head of Research and Early Development
    Genentech
    Original lecture date: March 11

    Watch lecture

     
     

    Douglas Hawkins portrait
     

    Successes and Challenges in Pediatric Cancer: The COG Perspective

    Douglas S. Hawkins, MD
    Chair of Children's Oncology Group
    Professor of Pediatrics
    University of Washington School of Medicine
    Seattle Children’s Hospital
    Original lecture date: March 18

    Watch lecture

     
     

    David T.W. Jones portrait
     

    Pediatric High-grade Glioma – Novel Drivers Define a Spectrum of New Tumor Subgroups

    David T.W. Jones, PhD
    Group Leader, 'Pediatric Glioma Research'
    Hopp Children’s Cancer Center (KiTZ)
    German Cancer Research Center (DKFZ)
    Original lecture date: March 25

    Watch lecture

     
     

    Karen Vousden portrait
     

    A Role for Metabolism in Cancer Development and Progression

    Karen Vousden, PhD
    Senior Group Leader
    The Francis Crick Institute
    Original lecture date: April 1

    Lecture not archived

     
     

    Anne Kirchhoff portrait
     

    Identifying Strategies to Improve HPV Vaccination Among Childhood Cancer Survivors

    Anne Kirchhoff, PhD, MPH
    Associate Professor, Pediatrics
    Investigator
    University of Utah/Huntsman Cancer Institute
    Original lecture date: April 8

    Watch lecture

     
     

    Madan Babu portrait
     

    Data Science Approaches to GPCR Signaling and Personalized Medicine

    Madan Babu, PhD, FRSC
    Endowed Chair in Biological Data Science
    Director, Center of Excellence for Data Driven Discovery
    Department of Structural Biology
    St. Jude Children’s Research Hospital
    Original lecture date: April 15

    Watch lecture

     
     

    Zhaoming Wang portrait
     

    Genetic and Epigenetic Approaches Towards Understanding Risk of Chronic Health Conditions Among Survivors of Childhood Cancer

    Zhaoming Wang, PhD
    Department of Epidemiology and Cancer Control
    Department of Computational Biology
    St. Jude Children’s Research Hospital
    Original lecture date: April 22

    Watch lecture

     
     

    Kimberly Stegmaier portrait
     

    A First-generation Pediatric Cancer Dependency Map

    Kimberly Stegmaier, MD
    Professor of Pediatrics, Harvard Medical School
    Ted Williams Chair and Vice Chair of Pediatric Oncology Research, Dana-Farber Cancer Institute
    Institute Member, Broad Institute of Harvard and MIT
    Original lecture date: April 29, 2021

    Watch lecture

     
     

    Cigall Kadoch portrait
     

    Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Cancer

    Cigall Kadoch, PhD
    Associate Professor, Department of Pediatric Oncology
    Dana-Farber Cancer Institute and Harvard Medical School
    Institute Member and Epigenomics Program Co-Director, Broad Institute
    Original lecture date: May 6, 2021

    Watch lecture

     
     
  4. Michel Sadelain portrait
     

    CAR T Cells: On the Road to Synthetic Immunity

    Michel Sadelain, MD, PhD
    Director, Center for Cell Engineering
    Stephen and Barbara Friedman Chair
    Member, Immunology Program
    Member, Departments of Medicine and Pediatrics
    Memorial Sloan-Kettering Cancer Center
    Original lecture date: August 13

    Watch lecture

     
     

    Charles W.M. Roberts portrait
     

    Chromatin Remodeler Mutations in Cancer: Mechanisms and Therapeutic Vulnerabilities

    Charles W.M. Roberts, MD, PhD
    Member, St. Jude Faculty
    Executive Vice President
    Director, Comprehensive Cancer Center
    Director, Division of Molecular Oncology
    Department of Oncology
    St. Jude Children's Research Hospital
    Original lecture date: August 20

    Watch lecture

     
     

    Terry Fry portrait
     

    The Future of CAR T Cells for Hematologic Malignancies: Beyond Antigen Targeting

    Terry J. Fry, MD
    Professor of Pediatrics, Hematology and Immunology
    Co-Director, Human Immunology and Immunotherapy Initiative and Director of Cancer Immunotherapy
    University of Colorado School of Medicine
    Robert and Kathleen Clark Endowed Chair in Pediatric Cancer Therapeutics
    Children’s Hospital Colorado, Center for Cancer and Blood Disorders
    Original lecture date: August 27

    Watch lecture

     
     

    Richard Kriwacki portrait
     

    Phase Separation in Gene Transcription: From the Nucleolus to Aberrant Transcription in Leukemia

    Richard W. Kriwacki, PhD
    Co-Leader, Cancer Biology Program
    Department of Structural Biology
    St. Jude Children's Research Hospital
    Original lecture date: September 3

    Watch lecture

     
     

    Smita Bhatia portrait
     

    Late Effects Among Survivors of Blood or Marrow Transplantation

    Smita Bhatia, MD, MPH
    Director, Institute for Cancer Outcomes and Survivorship
    Gay and Bew White Endowed Chair in Pediatric Oncology
    Professor and Vice Chair, Dept. of Pediatrics
    School of Medicine, University of Alabama at Birmingham
    Original lecture date: September 10

    Watch lecture

     
     

    Christine Brown portrait
     

    Advancing CAR T Cells for the Treatment of Glioblastoma: Progress and Challenges

    Christine Brown, PhD
    Heritage Provider Network Professor of Immunotherapy
    Deputy Director, T Cell Therapeutics Research Laboratory
    City of Hope
    Original lecture date: September 17

    Lecture not archived.

     
     

    Kevin Krull portrait
     

    Cognitive Outcomes of Childhood Cancer: Neurophysiology, Biomarkers and Interventions

    Kevin R. Krull, PhD
    Endowed Chair, Cancer Survivorship
    Faculty Member, Departments of Epidemiology and Cancer Control, and Psychology
    St. Jude Children's Research Hospital
    Original lecture date: September 24

    Watch lecture

     
     

    Ioannis Aifantis portrait
     

    3D Chromosomal Organization in Pediatric Leukemia: Impact for Drug Response and Disease Progression

    Iannis Aifantis, PhD
    Professor and Chair
    Department of Pathology and Perlmutter Cancer Center
    NYU Grossman School of Medicine
    Original lecture date: October 1

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    Paul Northcott portrait
     

    Medulloblastomics 2020: Biological & Clinical Insights From 1,000s of Patients

    Paul A. Northcott, PhD
    Associate Faculty Member, Department of Developmental Neurobiology
    Division of Brain Tumor Research
    St. Jude Children's Research Hospital
    Original lecture date: October 8

    Watch lecture

     
     

    Crystal Mackall portrait
     

    CAR T Cells for Pediatric Cancers: Progress and Challenges

    Crystal Mackall, MD
    Ernest and Amelia Gallo Family Professor of Pediatrics and Internal Medicine
    Founding Director, Stanford Center for Cancer Cell Therapy
    Director, Parker Institute for Cancer Immunotherapy at Stanford
    Associate Director, Stanford Cancer Institute
    Leader, Cancer Immunology and Immunotherapy Program
    Director, Cancer Immunotherapy Program
    Department of Pediatrics - Hematology & Oncology
    Department of Medicine - Blood & Marrow Transplantation
    Stanford University
    Original lecture date: October 15

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    Richard Young portrait
    Isaac Klein portrait
     

    Partitioning of Cancer Therapeutics in Nuclear Condensates

    Richard A. Young, PhD
    Professor, Department of Biology
    Member, Whitehead Institute
    Massachusetts Institute of Technology (MIT)

    Isaac A. Klein, MD, PhD
    Dana-Farber Cancer Institute
    Whitehead Institute
    Original lecture date: October 22

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    Rani George portrait
     

    Harnessing Lineage Plasticity for the Treatment of Neuroblastoma

    Rani George, MD, PhD
    Associate Professor of Pediatrics, Harvard Medical School
    Dept. of Pediatric Hematology/Oncology
    Dana-Farber Cancer Institute/Boston Children's Hospital
    Original lecture date: October 29

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    Paul Thomas portrait
     

    Organized Destruction and Destructive Organization: The Diversity of Immune Responses Towards Tumors and Pathogens

    Paul G. Thomas, PhD
    Faculty Member, Department of Immunology
    St. Jude Children's Research Hospital
    Original lecture date: November 5

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    Michelle Monje portrait
     

    Targeting Neuron-Glial Interactions in Childhood Brain Cancer

    Michelle Monje, MD, PhD
    Associate Professor, Neurology & Neurological Sciences
    Stanford University
    Original lecture date: November 12

    Watch lecture

     
     

    Eric Chow portrait
     

    Emerging Late Effects of Targeted Molecular Therapies

    Eric Chow, MD, MPH
    Associate Professor, Clinical Research Division
    Associate Professor, Public Health Sciences Division
    Director, Prevention Center Shared Resource
    Fred Hutchinson Cancer Research Center
    Medical Director, Cancer Survivorship Program
    Seattle Children's Hospital
    Associate Professor, Pediatrics
    University of Washington
    Original lecture date: November 19

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Comprehensive Cancer Center

St. Jude is the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children.

 
 


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