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CHANGE-seq-BE finds off-target changes in the genome from base editors
01/02/2026
Find how Circularization for High-throughput Analysis of Nuclease Genome-wide Effects by Sequencing Base Editors (CHANGE-seq-BE) improves finding off-targets.
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Structural findings reveal how distinct GPCR ligands create different levels of activation
12/22/2025
Find how GPCR G-protein activation differs between ligands, with partial agonists stuck longer in “kinetic traps” of intermediate states during the process.
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Revealing an invisible kinase state that accounts for vital biological function
12/18/2025
Learn how St. Jude scientists uncovered a hidden Src kinase state crucial for T-cell activation and cell migration, opening new paths for therapies.
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Combination therapy shows potential to treat pediatric brain cancer ATRT
12/16/2025
See how a combo therapy of idasantulin and Selinexor stimulate the p53 pathway through MDM2 and XPO1 to treat atypical teratoid rhabdoid tumors (ATRT)
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Accelerating drug combination discovery with machine learning
12/15/2025
Explore ComboCat, a St. Jude scientist-created system that combines machine learning and advanced liquid handling to speed up combination drug discovery.
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Membrane ‘neighborhood’ helps transporter protein regulate cell signaling
12/05/2025
See how protein kinase A, SCRIB, and other proteins help keep ABCC4 transporter levels steady in the membrane to regulate cyclic AMP signaling
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Research reveals how disordered protein regions contribute to cancer-causing condensates
12/03/2025
See how scientists use IDR-Puncta ML to predict which fusion oncoproteins form condensates, revealing new insights into cancer and RNA biology.
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Spatial Touchstone brings quality control to spatial transcriptomics
12/03/2025
Explore Spatial Touchstone’s open-source tools and data for standardized spatial transcriptomics, enabling reliable, cross-institutional gene expression analysis.
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Research reveals structural mechanism behind anti-epilepsy therapies
12/01/2025
Learn how epilepsy drugs reshape SV2A and how new modulators boost potency, paving the way for more effective epilepsy treatments.
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Inflammation and metabolic stress combine to drive a new cell death pathway: mitoxyperilysis
11/28/2025
Discover how St. Jude research uncovered an unknown cell death pathway triggered by innate immune activation and nutrient scarcity that may help treat cancer.
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