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The Science of Childhood Cancer

A 15-week virtual lecture series

 
 

The Science of Childhood Cancer is an interactive, weekly lecture series designed to engage the scientific community on key questions in pediatric cancer research. Invited speakers are leading experts across the spectrum of basic, translational, clinical and population science. 

A new 15-week season will launch in fall 2021, hosted by the St. Jude Comprehensive Cancer Center. Register to receive updates and an announcement when the new speaker lineup is released, and browse archived lectures from previous speakers.

 
 

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Hosts

  • Charles W. M. Roberts, MD, PhD

    Charles W. M. Roberts, MD, PhD

    Roberts

    Member, St. Jude Faculty

    • Executive Vice President
    • Director, Comprehensive Cancer Center
    • Director, Molecular Oncology Division
  • Charles G. Mullighan, MBBS (Hons), MSc, MD

    Charles G. Mullighan, MBBS (Hons), MSc, MD

    Mullighan

    Member, St. Jude Faculty

    • Deputy Director, Comprehensive Cancer Center
    • Co-Leader, Hematological Malignancies Program
    • Medical Director, St. Jude Biorepository

Prior Lectures

  1. Jinghui Zhang portrait
     

    Genomic Variants in Pediatric Cancer: Landscape, Precision Oncology, and Data Sharing Ecosystem

    Jinghui Zhang, PhD
    Chair, Department of Computational Biology
    St. Jude Endowed Chair in Bioinformatics
    St. Jude Children’s Research Hospital
    Original lecture date: January 28

    Watch lecture

     
     
    Richard Gilbertson portrait
     

    Will We Ever Cure Cancer?

    Richard Gilbertson, MD, PhD
    Li Ka Shing Chair of Oncology
    Head, Department of Oncology
    Director, Cancer Research UK Major Centre 
    University of Cambridge, England
    Original lecture date: February 4

    Watch lecture

     
     
    Scott Armstrong portrait
     

    Chromatin Complexes as Therapeutic Opportunities in Cancer

    Scott Armstrong, MD, PhD
    President, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center
    Chair, Department of Pediatric Oncology
    Dana-Farber Cancer Institute
    David G. Nathan Professor of Pediatrics
    Harvard Medical School
    Original lecture date: February 11

    Watch lecture

     
     
    Robin Yabroff portrait
     

    Financial Hardship After Childhood Cancer

    Robin Yabroff, PhD, MBA
    Scientific Vice President, Health Services Research
    American Cancer Society
    Original lecture date: February 18

    Watch lecture

     
     
    John Crispino portrait
     

    Mechanisms of Leukemogenesis in Children with Down Syndrome

    John Crispino, PhD, MBA
    Director, Division of Experimental Hematology
    The Wall Street Committee Endowed Chair
    Department of Hematology
    St. Jude Children’s Research Hospital
    Original lecture date: February 25

    Watch lecture

     
     
    Sheila Singh portrait
     

    Therapeutic Targeting of Self-Renewal of Medulloblastoma Stem Cells: Strategies for Blocking Recurrence

    Sheila Singh, MD, PhD, FRCS(C)
    Pediatric Neurosurgeon, McMaster Children's Hospital
    Professor of Surgery, McMaster University
    Principal Investigator, Stem Cell and Cancer Research Institute, McMaster University
    Senior Canada Research Chair in Human Cancer Stem Cell Biology
    University Scholar, Chair, McMaster College of Health Inventors
    Original lecture date: March 4

    Watch lecture

     
     
    Jinghui Zhang portrait
     

    Single Cell Atlases as Roadmaps in Pediatric Cancer

    Aviv Regev, PhD
    Head of Research and Early Development
    Genentech
    Original lecture date: March 11

    Watch lecture

     
     
    Douglas Hawkins portrait
     

    Successes and Challenges in Pediatric Cancer: The COG Perspective

    Douglas S. Hawkins, MD
    Chair of Children's Oncology Group
    Professor of Pediatrics
    University of Washington School of Medicine
    Seattle Children’s Hospital
    Original lecture date: March 18

    Watch lecture

     
     
    David T.W. Jones portrait
     

    Pediatric High-grade Glioma – Novel Drivers Define a Spectrum of New Tumor Subgroups

    David T.W. Jones, PhD
    Group Leader, 'Pediatric Glioma Research'
    Hopp Children’s Cancer Center (KiTZ)
    German Cancer Research Center (DKFZ)
    Original lecture date: March 25

    Watch lecture

     
     
    Karen Vousden portrait
     

    A Role for Metabolism in Cancer Development and Progression

    Karen Vousden, PhD
    Senior Group Leader
    The Francis Crick Institute
    Original lecture date: April 1

    Lecture not archived

     
     
    Anne Kirchhoff portrait
     

    Identifying Strategies to Improve HPV Vaccination Among Childhood Cancer Survivors

    Anne Kirchhoff, PhD, MPH
    Associate Professor, Pediatrics
    Investigator
    University of Utah/Huntsman Cancer Institute
    Original lecture date: April 8

    Watch lecture

     
     
    Madan Babu portrait
     

    Data Science Approaches to GPCR Signaling and Personalized Medicine

    Madan Babu, PhD, FRSC
    Endowed Chair in Biological Data Science
    Director, Center of Excellence for Data Driven Discovery
    Department of Structural Biology
    St. Jude Children’s Research Hospital
    Original lecture date: April 15

    Watch lecture

     
     
    Zhaoming Wang portrait
     

    Genetic and Epigenetic Approaches Towards Understanding Risk of Chronic Health Conditions Among Survivors of Childhood Cancer

    Zhaoming Wang, PhD
    Department of Epidemiology and Cancer Control
    Department of Computational Biology
    St. Jude Children’s Research Hospital
    Original lecture date: April 22

    Watch lecture

     
     
    Kimberly Stegmaier portrait
     

    A First-generation Pediatric Cancer Dependency Map

    Kimberly Stegmaier, MD
    Professor of Pediatrics, Harvard Medical School
    Ted Williams Chair and Vice Chair of Pediatric Oncology Research, Dana-Farber Cancer Institute
    Institute Member, Broad Institute of Harvard and MIT

    Watch lecture

     
     
    Cigall Kadoch portrait
     

    Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Cancer

    Cigall Kadoch, PhD
    Associate Professor, Department of Pediatric Oncology
    Dana-Farber Cancer Institute and Harvard Medical School
    Institute Member and Epigenomics Program Co-Director, Broad Institute

    Archived lecture coming soon.

     
     
  2. Michel Sadelain portrait
     

    CAR T Cells: On the Road to Synthetic Immunity

    Michel Sadelain, MD, PhD
    Director, Center for Cell Engineering
    Stephen and Barbara Friedman Chair
    Member, Immunology Program
    Member, Departments of Medicine and Pediatrics
    Memorial Sloan-Kettering Cancer Center
    Original lecture date: August 13

    Watch lecture

     
     
    Charles W.M. Roberts portrait
     

    Chromatin Remodeler Mutations in Cancer: Mechanisms and Therapeutic Vulnerabilities

    Charles W.M. Roberts, MD, PhD
    Member, St. Jude Faculty
    Executive Vice President
    Director, Comprehensive Cancer Center
    Director, Division of Molecular Oncology
    Department of Oncology
    St. Jude Children's Research Hospital
    Original lecture date: August 20

    Watch lecture

     
     
    Terry Fry portrait
     

    The Future of CAR T Cells for Hematologic Malignancies: Beyond Antigen Targeting

    Terry J. Fry, MD
    Professor of Pediatrics, Hematology and Immunology
    Co-Director, Human Immunology and Immunotherapy Initiative and Director of Cancer Immunotherapy
    University of Colorado School of Medicine
    Robert and Kathleen Clark Endowed Chair in Pediatric Cancer Therapeutics
    Children’s Hospital Colorado, Center for Cancer and Blood Disorders
    Original lecture date: August 27

    Watch lecture

     
     
    Richard Kriwacki portrait
     

    Phase Separation in Gene Transcription: From the Nucleolus to Aberrant Transcription in Leukemia

    Richard W. Kriwacki, PhD
    Co-Leader, Cancer Biology Program
    Department of Structural Biology
    St. Jude Children's Research Hospital
    Original lecture date: September 3

    Watch lecture

     
     
    Smita Bhatia portrait
     

    Late Effects Among Survivors of Blood or Marrow Transplantation

    Smita Bhatia, MD, MPH
    Director, Institute for Cancer Outcomes and Survivorship
    Gay and Bew White Endowed Chair in Pediatric Oncology
    Professor and Vice Chair, Dept. of Pediatrics
    School of Medicine, University of Alabama at Birmingham
    Original lecture date: September 10

    Watch lecture

     
     
    Christine Brown portrait
     

    Advancing CAR T Cells for the Treatment of Glioblastoma: Progress and Challenges

    Christine Brown, PhD
    Heritage Provider Network Professor of Immunotherapy
    Deputy Director, T Cell Therapeutics Research Laboratory
    City of Hope
    Original lecture date: September 17

    Lecture not archived.

     
     
    Kevin Krull portrait
     

    Cognitive Outcomes of Childhood Cancer: Neurophysiology, Biomarkers and Interventions

    Kevin R. Krull, PhD
    Endowed Chair, Cancer Survivorship
    Faculty Member, Departments of Epidemiology and Cancer Control, and Psychology
    St. Jude Children's Research Hospital
    Original lecture date: September 24

    Watch lecture

     
     
    Ioannis Aifantis portrait
     

    3D Chromosomal Organization in Pediatric Leukemia: Impact for Drug Response and Disease Progression

    Iannis Aifantis, PhD
    Professor and Chair
    Department of Pathology and Perlmutter Cancer Center
    NYU Grossman School of Medicine
    Original lecture date: October 1

    Watch lecture

     
     
    Paul Northcott portrait
     

    Medulloblastomics 2020: Biological & Clinical Insights From 1,000s of Patients

    Paul A. Northcott, PhD
    Associate Faculty Member, Department of Developmental Neurobiology
    Division of Brain Tumor Research
    St. Jude Children's Research Hospital
    Original lecture date: October 8

    Watch lecture

     
     
    Crystal Mackall portrait
     

    CAR T Cells for Pediatric Cancers: Progress and Challenges

    Crystal Mackall, MD
    Ernest and Amelia Gallo Family Professor of Pediatrics and Internal Medicine
    Founding Director, Stanford Center for Cancer Cell Therapy
    Director, Parker Institute for Cancer Immunotherapy at Stanford
    Associate Director, Stanford Cancer Institute
    Leader, Cancer Immunology and Immunotherapy Program
    Director, Cancer Immunotherapy Program
    Department of Pediatrics - Hematology & Oncology
    Department of Medicine - Blood & Marrow Transplantation
    Stanford University
    Original lecture date: October 15

    Watch lecture

     
     
    Richard Young portrait
    Isaac Klein portrait
     

    Partitioning of Cancer Therapeutics in Nuclear Condensates

    Richard A. Young, PhD
    Professor, Department of Biology
    Member, Whitehead Institute
    Massachusetts Institute of Technology (MIT)

    Isaac A. Klein, MD, PhD
    Dana-Farber Cancer Institute
    Whitehead Institute
    Original lecture date: October 22

    Watch lecture

     
     
    Rani George portrait
     

    Harnessing Lineage Plasticity for the Treatment of Neuroblastoma

    Rani George, MD, PhD
    Associate Professor of Pediatrics, Harvard Medical School
    Dept. of Pediatric Hematology/Oncology
    Dana-Farber Cancer Institute/Boston Children's Hospital
    Original lecture date: October 29

    Watch lecture

     
     
    Paul Thomas portrait
     

    Organized Destruction and Destructive Organization: The Diversity of Immune Responses Towards Tumors and Pathogens

    Paul G. Thomas, PhD
    Faculty Member, Department of Immunology
    St. Jude Children's Research Hospital
    Original lecture date: November 5

    Watch lecture

     
     
    Michelle Monje portrait
     

    Targeting Neuron-Glial Interactions in Childhood Brain Cancer

    Michelle Monje, MD, PhD
    Associate Professor, Neurology & Neurological Sciences
    Stanford University
    Original lecture date: November 12

    Watch lecture

     
     
    Eric Chow portrait
     

    Emerging Late Effects of Targeted Molecular Therapies

    Eric Chow, MD, MPH
    Associate Professor, Clinical Research Division
    Associate Professor, Public Health Sciences Division
    Director, Prevention Center Shared Resource
    Fred Hutchinson Cancer Research Center
    Medical Director, Cancer Survivorship Program
    Seattle Children's Hospital
    Associate Professor, Pediatrics
    University of Washington
    Original lecture date: November 19

    Watch lecture

     
     

Comprehensive Cancer Center

St. Jude is the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children.