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Inspiration4 and St. Jude

A journey to space. A cause for humanity.

Inspiration4 is the world's first all-civilian mission to orbit the Earth. St. Jude is the charitable beneficiary of Inspiration4. Our goal is to raise $200 million for kids with cancer and other life-threatening diseases in honor of this mission.

Donate to St. Jude Other Ways to Get Involved


Watch the Inspiration4 crew in space! And check back Sept. 18 to watch the splashdown LIVE.


From cancer patient to astronaut

As a kid, Hayley Arceneaux was treated at St. Jude for osteosarcoma. Now she's a St. Jude physician assistant with a seat to space on Inspiration4.

Read About Hayley's Journey


See the Inspiration4 payload auction items

Take a look at some of the items that are in orbit right now, as well as one-of-a-kind experiences that could be yours — all to benefit St. Jude kids here on Earth. 

Check Out the Auction


Watch the Inspiration4 splashdown

Currently scheduled for Saturday, Sept. 18

Splashdown will be livestreamed on this page. Check back for more information about the exact time.

See a Replay of the Launch


Staying here on Earth?

We invite you to be part of our effort to make a better world for the future. Contribute to our $200 million goal, and learn more about this historic spaceflight.

Jacket with Inspiration4 artwork.

Items are launching into space aboard Inspiration4, and they could be yours when they return to Earth. Proceeds benefit St. Jude.

Check out our auction.

Puggle and Huckleberry sit with the plush toys they inspired.

St. Jude facility dogs Puggle and Huckleberry inspired the official zero-gravity indicator the crew has on board. Get yours at the St. Jude Gift Shop.

More are on the way Sept. 27! Shop more of our space collection.

Black and white photo of Kings of Leon.

It’s your chance to own history! Bid on the St. Jude NFT featuring Kings of Leon — the first NFT song to be played in space. Proceeds benefit St. Jude.

Bid on Kings of Leon.

Netflix poster.

Countdown: Inspiration4 Mission to Space is a documentary series that will cover the events in near real-time, airing in five parts leading up to and after the mission.

Watch the documentary on Netflix.

Inspiration4 jacket, hat, and coffee mug.

Show your support for this remarkable milestone with a flight jacket, coffee mug and more. Proceeds benefit St. Jude.

Explore Inspiration4 gear.

Socks and T-shirt with art inspired by St. Jude patient Colton.

Shop our space collection inspired by the artwork of St. Jude patient Colton, or browse through our whole selection. Proceeds benefit St. Jude.

Shop the St. Jude Gift Shop.

A piece of art by Dr. Proctor depicting two women in space.

NFTs, Inspiration4 digital patches and more, all from the Prosperity seat winner. Proceeds benefit St. Jude.

See Dr. Proctor's art.

St. Jude Mission of a Lifetime podcast logo.

Hear the story of Hayley Arceneaux and the other crew members of Inspiration4 in "St. Jude Mission of a Lifetime."

Listen to our podcast.

St. Jude patient Zahaan playing in his hospital room.

Want to make an immediate impact? Help us meet our fundraising goal by donating to help St. Jude kids.

Donate to Inspiration4.


Meet the Inspiration4 crew

Named for its four-person crew and its mission to inspire support for the lifesaving work of St. Jude, Inspiration4 is commanded by Jared Isaacman. The four crew members represent the mission’s pillars of Leadership, Hope, Prosperity and Generosity.

Headshot of Jared Isaacman.

Jared Isaacman

Commander and benefactor

Leadership seat

Headshot of Hayley Arceneaux.

Hayley Arceneaux

St. Jude cancer survivor

Hope seat

Headshot of Dr. Sian Proctor.

Dr. Sian Proctor

Shift4Shop owner

Prosperity seat

Headshot of Chris Sembroski.

Christopher Sembroski

St. Jude donor

Generosity seat


Sign up for email updates to learn more about how you can help St. Jude continue to save lives.

The Earth from space.
Patient Abraham with his mom.

St. Jude patient Abraham, with his mom.


About St. Jude

St. Jude Children's Research Hospital is leading the way the world understands, treats and defeats childhood cancer and other life-threatening diseases. And families never receive a bill from St. Jude for anything.

St. Jude freely shares its groundbreaking discoveries, and every child saved at St. Jude means doctors and scientists can use that knowledge to save thousands more children around the world. Learn more.