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St. Jude and Inspiration4

A journey to space. A cause for humanity. Join us for a first-of-its-kind spaceflight and an ambitious goal for the kids here on Earth.

St. Jude/Inspiration4 logo lockup.

Inspiration4, launching later this year, is the world's first all-civilian space expedition, named for its four-person crew and its mission to inspire support for the lifesaving work of St. Jude.

In honor of this historic flight, we're raising $200 million to help find cures for childhood cancer and other life-threatening diseases. We invite you to be part of our effort to make a better world for the future.

Meet the crew


Jared Isaacman

Commander and benefactor


Hayley Arceneaux

St. Jude cancer survivor


Dr. Sian Proctor

Shift4Shop owner


Christopher Sembroski

St. Jude donor


As much as we’d like to conquer and drive progress in space, you can’t ignore the problems of the world we live in today. One of the things we hope to accomplish is ... to inspire people what's possible that can still be done here on Earth.

- Jared Isaacman, commander and benefactor of Inspiration4

Join our mission crew.

Be part of space — and St. Jude — history

St. Jude Mission: Inspired is a fundraising campaign that aspires to a brighter tomorrow. Join our quest to raise $200 million, and know that you'll have done your part to help us save children’s lives here on Earth.

Join the Adventure


What you'll get along the way:

SpaceX launch.

Once-in-a-lifetime experiences

From messages from the crew to behind-the-scenes footage, you'll have the chance to gain access to exclusive Inspiration4 experiences.

Flight jacket.

Space-themed rewards

Reach a fundraising milestone and earn something cool. It's as simple as that.

SpaceX launch.

Inspiration4 launch experience

When Inspiration4 lifts off, we want you to be there. A lucky fundraiser will get to watch the launch (stay tuned for details). 

The fundraising journey of St. Jude Mission: Inspired.

The more you fundraise, the more you'll uncover

Your fundraising mission aligns with the ideals of the Inspiration4 flight. You'll start earning gear with your very first donation and get an exclusive enamel pin with each new mission pillar. See the details.

Mission: Hope enamel pin.




$500 could help provide one hour of physical therapy for a St. Jude patient.*

Arc shape

$100 - Limited edition T-shirt

$250 - Fisher Space Pen Bullet

$500 - 3D moon-shaped night light

Mission: Leadership enamel pin.



RAISE UP TO $1,500

$1,500 could help cover the cost of four chest X-rays.*

Arc shape

$750 - Water-repellant microfiber picnic blanket

$1,000 - Urban Peak cooler

$1,500 - North Face backpack


Mission: Prosperity enamel pin.



RAISE UP TO $5,000

$5,000 could help cover the cost of the daily room rate of the ICU.*

Arc shape

$3,000 - Nylon flight jacket

$5,000 - Telescope


Mission: Generosity enamel pin.



RAISE UP TO $15,000

$15,000 could help run the St. Jude Blood Donor Center for one week.*

Arc shape

$7,500 - JBL bluetooth speaker

$10,000 - Camping package

$15,000 - DJI Mavic air drone



* When you make a donation using this information, your donation will be used to provide breakthrough research, treatment and cures.  Items listed here are representative of services and supplies that are part of the treatment and care of children at St. Jude.  The cost of each item or service is an approximation, and will vary based on actual costs incurred and individual patient needs.  Your donation will be used for the general operating needs of St. Jude, where no family ever receives a bill for treatment, travel, housing or food.

The Earth from space.

Educators and parents: Know a little learner with big ideas? Check out the Inspiration4 St. Jude Science Fair to engage students with this historic mission.

Patient Abraham with his mom.

St. Jude patient Abraham, with his mom.

About St. Jude

St. Jude Children's Research Hospital is leading the way the world understands, treats and defeats childhood cancer and other life-threatening diseases. And families never receive a bill from St. Jude for anything.

St. Jude freely shares its groundbreaking discoveries, and every child saved at St. Jude means doctors and scientists can use that knowledge to save thousands more children around the world. Learn more.

Inspiration4 commemorative patch

Inspiration4 commemorative patch.

About Inspiration4 and Jared Isaacman

Inspiration4, named for its four-person crew, will be an all-civilian space expedition commanded by Jared Isaacman, renowned pilot, adventurer and founder and CEO of Shift4 Payments. The crew of Inspiration4 will symbolize the best of humanity: Leadership, Hope, Prosperity and Generosity. The flight will raise awareness and funds for St. Jude. Learn more.


Staying here on Earth?

There are no more empty seats on Inspiration4, but there are still plenty of ways to get involved. As we count down to this historic mission, be part of the excitement, and help us meet our fundraising goal.

Enter to win.

Sign up to fundraise and help St. Jude accelerate research advancements and save more children worldwide. You'll unlock rewards as you go.

Donate to St. Jude icon.

Prefer not to fundraise? You can still help us meet our goal by donating to help St. Jude kids.

Sign up for email updates.

Stay up-to-date on how St. Jude will be celebrating the launch, and learn more about how you can help St. Jude continue to save lives.

Explore Inspiration4.

Show your support for this remarkable milestone with a flight jacket, coffee mug and more. Proceeds benefit St. Jude.

Patient Abraham.

St. Jude patient Abraham, with his copilot.