The Chemical Biology and Therapeutics (CBT) Department formulates innovative chemical and chemoinformatic solutions to resolve salient problems in biology and medicine. Fundamental research programs to uncover underlying biological processes are complemented by translational centers that house chemical synthesis, screening, and computational capabilities that mirror cutting-edge biotech/pharma operations, resources rarely accessible at academic institutions.
The expertise and resources of CBT are leveraged across the institution, making it a highly dynamic and diverse collaborative hub at St. Jude. The scientific research arm of CBT is in an exciting growth phase; individuals with bold vision and demonstrated excellence in research at the interface of Chemistry, Biology, and Medicine are encouraged to join the team.
Designing synthetic gene switches for transcription therapy
Understanding structure-function relationships in complex biochemical systems at the single-molecule scale
Deciphering transcriptional regulation of therapeutic responses
Understanding the chemical biology of essential protein machines
Exploring the protein conformational landscape for ligand discovery
Discovering new antibiotics and other therapeutics using medicinal chemistry and chemical biology
Investigating programmed cell death in cancer biology
Exploring novel treatment approaches for metastatic disease and elucidating the mechanisms that drive drug activation
Identifying and translating druggable liabilities in pediatric cancers
Leading state-of-the-art chemistry technologies, the CBT Centers focus on collaborative research with St. Jude’s investigators to further our understanding of the biological mechanisms in childhood diseases, with the goal of translating this knowledge into new therapeutic opportunities.
St. Jude investigators have the freedom to focus on making big discoveries, backed by extraordinary resources and support teams. We are always looking for highly motivated scientists and engineers with passion and talent to join us!