About the lab

Bone marrow failure syndromes are rare diseases that occur when the bone marrow fails to produce blood cells (white cells, red cells and platelets). This causes a myriad of health complications for children affected by these syndromes, including an increased risk of developing blood cancers such as myelodysplastic syndrome and leukemia. We are interested in identifying the genetic components that drive bone marrow failure syndromes as well as understanding the biology behind what causes some children with these disorders to develop cancer. 

Science Team

Kennedy research summary

Some children are born with a tendency to develop bone marrow failure disorders. In many cases, these disorders progress to blood disorders such as leukemia. However, the molecular mechanisms driving this progression are not well understood. We aim to determine the molecular underpinnings of these disorders and identify additional mutations that play a role in the malignant transformation into leukemia.  

Shwachman-Diamond Syndrome

My lab focuses on a specific type of bone marrow failure disorder called Shwachman-Diamond Syndrome (SDS). SDS is a recessively inherited disorder most often caused by a mutation in the SBDS gene, located on the long arm of chromosome 7. This gene encodes a protein called SBDS protein which is instrumental in eukaryotic ribosomal maturation and, therefore, normal ribosomal function.

Patients with this disorder have defects in ribosome maturation and translation and can develop bone marrow failure with a high risk of leukemia. Certain somatic mutations are more likely to cause cancer whereas other mutations are actually beneficial to the bone marrow and improve cell survival without causing cancer. We are investigating which mutations are malignant and which are adaptive. 

We use in vitro cell culture modeling including induced pluripotent stem cells, translational assays, single-cell genomics and functional genomic approaches to determine how somatic mutations affect SDS-induced ribosomal defect and to determine whether these mutations either contribute to malignancy or act in a compensatory manner to alleviate the disorder.   

Our goal is to identify genetic biomarkers for patients with bone marrow failure that can be used to indicate an increased risk of malignancy and develop the next generation of therapeutics that can be used to treat these children before they develop cancer. 


About Alyssa Kennedy

Dr. Kennedy is a pediatric oncologist who received both her MD and PhD from Drexel University College of Medicine in Pennsylvania. She then completed a residency in pediatrics at the Boston Combined Residency program, followed by a pediatric hematology/oncology fellowship at the Dana-Farber Cancer Institute/Boston Children’s Hospital. Dr. Kennedy is interested in understanding the mechanisms of leukemogenesis in bone marrow failure syndromes in order to better prognosticate for patients and develop novel therapies. In addition to her research, Dr. Kennedy actively sees both bone marrow failure and hematologic malignancy patients as a member of the Department of Hematology.  

photo of Alyssa Kennedy

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We are always looking for highly self-motivated scientists/engineers with passion and talent to join us! People with experimental background are also encouraged to apply.

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Alyssa Kennedy, MD, PhD
Assistant Member, Department of Hematology
St. Jude Children's Research Hospital

262 Danny Thomas Place
Memphis, TN, 38105-3678 USA

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262 Danny Thomas Place
Memphis, TN, 38105-3678 USA