Our Research Mission

The engine of discovery at St. Jude is powered by some of the most reputable minds in science and medicine, equipped with world-class resources and driven by the shared mission of advancing cures. We understand that fundamental science builds the foundation for clinical impact. We are committed to supporting hypothesis-driven and exploratory research that asks daring questions to drive innovation.

The mission of St. Jude Children's Research Hospital is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. Consistent with the vision of our founder Danny Thomas, no child is denied treatment based on race, religion or a family’s ability to pay.

St. Jude Scientific Milestones

More than half a century ago, entertainer Danny Thomas envisioned a hospital that would care for children regardless of race, color, creed, or their family’s ability to pay. He recognized that scientific research and discovery would create the foundation to help treat children facing catastrophic diseases. Since St. Jude opened its doors on February 4, 1962, it has become one of the world’s premier pediatric research institutions. Explore the scientific milestones that have marked our progress from that day to now.

ARC buildings looking up to the sky

Extraordinary Collaboration

The culture and campus of St. Jude fosters free exchange of ideas among scientists and clinicians for creative, comprehensive science. Connections between faculty laboratories and massive collaborative initiatives position St. Jude as a leader in interdisciplinary basic and translational research. Science is not a singular enterprise, but a social endeavor defined by compassion and creativity. The relationships built, internal and external, expand the scope of the work and the reach of St. Jude’s impact. To further advance cures, St. Jude freely shares data and analytical tools with the global scientific community.

Three scientists

Innovative Facilities

St. Jude supports scientific research by investing in resources, technologies, and infrastructure that represent a robust discovery and development pipeline that is unusual among academic institutions. From expanding computing and informatics capabilities, to building the world’s premier center for structural analysis and imaging of biomolecules, St. Jude fosters the growth of a physical environment to drive success. The Advanced Research Center accommodates 90 strategically positioned, cross-collaborative, research teams in their pursuit of understanding in RNA biology, epigenetics, and metabolomics. The campus and facilities of St. Jude bring expert faculty together with extraordinary, shared resources and financial support mechanisms to power transformative research. 

Innovative Facilities

Unique Funding Model

While St. Jude investigators and trainees are well-equipped and incredibly successful at securing competitive external funding, dedicated institutional support ensures that our researchers have the security and confidence to pursue transformative and daring questions. St. Jude  is supported by ALSAC, one of the world’s leading nonprofit charitable organizations. ALSAC is solely dedicated to raising the funds necessary to operate and maintain St. Jude. This unique model affords researchers access to exceptional resources and a remarkable degree of investigative freedom.

Secure funding

Unparalleled Shared Resources

St. Jude has over 20 core facilities and research resources that provide expertise and cutting-edge technologies to support collaborative work across the institution. The scientists and technologists who staff the facilities can serve as expert hands, consultants, in-depth trainers, or full collaborators in the development of new approaches. In addition to sample processing, each center supports investigators in the design, performance, and analysis of experiments. These shared resources expand capabilities, accelerate research and foster innovation. Additional support centers provide publication assistance, data storage and analytics, grants management, and technology licensing.

Shared resources

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