St. Jude Research

Clinical

Find out how research at St. Jude underlies clinical progress in the care and treatment of cancer, blood disorders, neurological disease and more. 

Man and woman talking while standing next to a table.
Man and woman talking while standing next to a table.

Clinical trial disentangles immune issues and boosts anti-cancer effect of bone marrow transplantation

Brian O'Flynn, PhD

Phase II clinical trial results show promise in reducing graft-versus-host disease

Artistic rendering showing calendar months going by from left to right, with three versions of a person with sickle cell disease experiencing worse outcomes the longer they take to transition to adult care.
Artistic rendering showing calendar months going by from left to right, with three versions of a person with sickle cell disease experiencing worse outcomes the longer they take to transition to adult care.

Shortening the gap between pediatric and adult care improves sickle cell outcomes

Alex Generous, PhD

Closing the time gap between pediatric and adult care could have significant benefits for patients.

A man and a woman sitting on a hospital bed and talking to each other
A man and a woman sitting on a hospital bed and talking to each other

Bone marrow transplantation for sickle cell disease improves myocardial fibrosis

Erin Podolak, MA

St. Jude scientists have found for the first time that myocardial fibrosis caused by sickle cell disease can actually be improved by bone marrow transplantation.

Abstract image of a brain in a cave
Abstract image of a brain in a cave

Uncovering the source of a “silent” syndrome

Brian O'Flynn, PhD

Discover the neuronal interactions at the center of posterior fossa syndrome

Doctor talking to patient in hospital room
Doctor talking to patient in hospital room

Boot camp trains sickle cell disease ‘pain crises champions’ to improve patient care

 Alex Generous, PhD

St. Jude and UTHSC are training nurses worldwide how to better care for people with sickle cell disease.

Long-acting injectable HIV drugs safe for treating adolescents

Alex Generous, PhD

Learn how long-lasting drugs offer hope for adolescent with HIV.

Preventing sepsis during treatment for pediatric cancer might prevent neurocognitive problems decades later in survivors

 Alex Generous, PhD

Childhood sepsis during cancer treatment appears to have a lasting impact on only one organ.

‘It was the right time’: A bench-to-bedside journey for the targeted treatment of pediatric low-grade gliomas

Kathryn J. McCullough, MA

Over a decade of research brings a treatment to the forefront for children with low-grade gliomas. For Olivia Thatcher, that treatment came at the right time.

St. Jude investigator led multi-center effort to define Diamond Blackfan anemia syndromes’ guidelines

 Alex Generous, PhD

Explore the newly published guidelines for Diamond Blackfan anemia syndromes.

Shared Resources Spotlight: Experimental Cellular Therapy Laboratory (ECTL)

Emilia Asante, PhD

Experimental Cellular Therapy advances GMP compliant processes for cellular products developed by St. Jude investigators