Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

Death-defying mechanism drives premature aging in blood stem cells after transplant

Alex Generous, PhD

Discover how mitochondria help stem cells re-establish the blood system at the cost of accelerated aging.

AI-driven μPharma platform accurately predicts leukemia drug sensitivity

Brian O'Flynn, PhD

See how an artificial intelligence single-cell microfluidics pharmacotyping tool helps identify drugs for T-cell acute lymphoblastic leukemia

Center for Infectious Diseases Research takes aim at pediatric pathogens

Ashley DuMont, PhD

Learn how the Center for Infectious Diseases Research is facilitating collaborations across departments at St. Jude.

Browsing tumor library sparks understanding of drug resistance in childhood kidney cancer

Brian O'Flynn, PhD

See how a patient-derived xenograft library is shaping Wilms tumor treatments.

Peripheral blood tests aid leukemia surveillance for bone marrow failure

Alex Generous, PhD

Learn how a simple test could detect leukemia at an earlier stage and improve outcomes.

Parallel analysis method cracks scalable single-molecule imaging

Alex Generous, PhD

Clever engineering widens researchers’ view of the single-molecule scale.

Biostatisticians make clinical trial data more dynamic to gain deeper insights

Alex Generous, PhD

Find how a new statistical package is getting more out of trial analysis.

Technology advances unlock the mystery of mitochondrial DNA — our “other” genome

Brian O'Flynn, PhD

See how tools like mitoedit and NETBID reveal mitochondrial DNA (mtDNA) ties to diseases such as acute lymphoblastic leukemia

Collaborative science fuels innovation in immunotherapy effort to treat brain tumors

Alex Generous, PhD

Learn about how an award-winning scientific collaboration is pushing forward novel cancer therapies.

Solving the mysterious case of DICER1 cancer predisposition for pediatric rhabdomyosarcoma

Alex Generous, PhD

Investigate the decades-long cold case that St. Jude researchers finally cracked.