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NPM1 Exhibits Structural and Dynamic Heterogeneity upon Phase Separation with the p14ARF Tumor Suppressor. Journal of Magnetic Resonance. (2019)
Authors and Affiliations:
Eric Gibbs
Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place Memphis, Tennessee 38105, USA; Memphis, Tennessee 38112, USA; Email: eric.gibbs@stjude.org
Richard W. Kriwacki
Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place Memphis, Tennessee 38105, USA; Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Sciences Center, 910 Madison Avenue, Memphis, Tennessee 38163, USA; Email: richard.kriwacki@stjude.org
Barbara Perrone
Bruker Switzerland AG, Industriestrasse 26, CH-8117 Fällanden, Switzerland
Alia Hassan
Bruker Switzerland AG, Industriestrasse 26, CH-8117 Fällanden, Switzerland
Rainer Kümmerle
Bruker Switzerland AG, Industriestrasse 26, CH-8117 Fällanden, Switzerland
| Filename | Size | Description |
|---|---|---|
| NPM1_2PERCENT_DMSO_TROSY-HSQC.ucsf | 4.19 MB | TROSY-HSQC of [2H,15N]-NPM1, collected in the presence of 2% DMSO |
| NPM1_TROSY-HSQC.ucsf | 4.19 MB | TROSY-HSQC of [2H,15N]-NPM1 |
| p14ARF_NPM1_DP_CC-DARR.ucsf | 33.54 MB | CC-DARR spectrum of [U13C,U15N]-NPM1-p14ARF condensed phase |
| p14ARF_NPM1_DP_INEPT-TOBSY.ucsf | 8.39 MB | INEPT-TOBSY spectrum of [U13C,U15N]-NPM1-p14ARF condensed phase |
| p14ARF_NPM1_DP_NCA.ucsf | 33.55 MB | NCA spectrum of [U13C,U15N]-NPM1-p14ARF condensed phase |
| p14ARF_NPM1_DP_NCACX2D.ucsf | 2.09 MB | 2D NCACX spectrum of [U13C,U15N]-NPM1-p14ARF condensed phase |
| p14ARF_NPM1_DP_NCACX3D.ucsf | 268.44 MB | 3D NCACX spectrum of [U13C,U15N]-NPM1-p14ARF condensed phase |
| p14ARF_NPM1_DP_NCO.ucsf | 8.39 MB | NCO spectrum of [U13C,U15N]-NPM1-p14ARF condensed phase |
| p14ARF_NPM1_DP_NCOCX3D.ucsf | 1.07 GB | 3D NCOCX spectrum of [U13C,U15N]-NPM1-p14ARF condensed phase |
Exploring Relationships between the Density of Charged Tracts within Disordered Regions and Phase Separation
Ramiz Somjee
Department of Structural Biology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place Memphis, Tennessee 38105, USA;
Department of Chemistry, Rhodes College, 2000 North Parkway
Memphis, Tennessee 38112, USA;
Email: ramiz.somjee@stjude.org
Diana M. Mitrea
Department of Structural Biology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place Memphis, Tennessee 38105, USA
Email: diana.mitrea@stjude.org
Richard W. Kriwacki
Department of Structural Biology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place Memphis, Tennessee 38105, USA;
Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Sciences Center, 910 Madison Avenue, Memphis, Tennessee 38163, USA;
Email: richard.kriwacki@stjude.org
- Supplemental Figures and Tables.pdf: Contains Supplemental Figures 1 & 2 and Supplemental Table 1
- Supplemental Data 1.xlsx: Proteins in each Group with ABTdensity and ABTscore values. Lists of proteins in each cluster for the interaction network analysis.
- Supplemental Data 2.xlsx: Full results of Gene Ontology Enrichment analysis described in Figure 3 and Supplemental Figure 1
- Supplemental Data 3.xlsx: Full results of Gene Ontology Enrichment analysis for clusters described in Table 3 and Supplemental Table 1