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October 11, 2021
Koon-Kiu Yan contributed to the study on miR-424/503 regulating Wnt signaling in mammary epithelium in collaboration with Drs. Jose Silva and David Llobet-Navas, published in EMBO Reports!

October 5, 2021
Jiyang chaired the Session 2, Qingfei Pan (oral) and Jingjing Liu (poster) presented in this exciting Cell-NCI Symposium: Beyond Cancer Genomics Toward Precision Oncology!

October 4, 2021
Congrats Xu Yang for being promoted to Bioinformatics Research Scientist!

September 15, 2021
Yu Lab, together with the laboratory of Dr. Jun J. Yang, are thrilled to receive the U01 award, entitled “Clonal Therapy for Pediatric T-cell Acute Lymphoblastic Leukemia”, funded by NCI Cancer Systems Biology Consortium! It’s exciting to extend our previous work on dasatinib/venetoclax in T-ALL to identifying novel clonal therapies for kids with T-ALL!

September 6, 2021
Welcome Lei Yan joining the Yu Lab as a Sr. Bioinformatics Software Engineer!

August 19, 2021
Koon-Kiu Yan contributed to the study on SLFN11 published in Molecular Cancer Therapeutics!

August 2, 2021
Welcome Jiyuan Yang joining the Yu Lab as a Postdoc Fellow!

July 26, 2021
Welcome Yogesh Dhungana officially joining the Yu Lab as a PhD student!

July 12, 2021
Welcome Ram Pandey joining the Yu Lab as a Bioinformatics Research Scientist!

July 7, 2021
Tracy Qian, Yogesh Dhungana, and Hao Shi contributed to this beautiful Nature paper by Dr. Hongbo Chi on metabolic control TFH cells! Another terrific application of in vivo CRISPR screening!

April 27, 2021
Congrats to Koon-Kiu for contributing to this study on miR-424/503 in immunology in collaboration with Drs. Jose Silva and Herbert Strobl, published in Cell Reports!

March 25, 2021
Jiyang is promoted to Associate Member. What an achievement within 4.5 years! Big congrats!!

March 24, 2021
Our T-ALL study was highlighted and nicely summarized by a News & Views article at Nature Cancer!

March 4, 2021
Hao Shi, Yogesh Dhungana, and Tracy Qian contributed to this beautiful Cell paper by Dr. Hongbo Chi on novel metabolic regulators of CD8 T cell fate decisions! Another terrific application of in vivo CRISPR screening!

January 21, 2021
The dasatinib in T-ALL story is out today in Nature Cancer! It’s a wonderful collaboration between our lab and Dr. Jun J. Yang’s Lab. It’s yet another successful application of NetBID. Congratulations to Jingjing (co-first author) who led the NetBID analysis. NetBID identified LCK as the hidden driver and target that drives dasatinib sensitivity in >40% of children with T-ALL. More importantly, this discovery is being translated into multiple clinical trials.

January 19, 2021
Congratulations to Xu and Jiyang who contributed to the new Blood paper to identify putative drivers of erythroleukemia. It is a collaboration with Dr. Charles G. Mullighan’s lab.

January 12, 2021
Congratulation to Jiyang for delivering his promotion talk! Job well done!

October 6, 2020
Welcome Sheetal Bhatara to join our group as a Research Technologist! She will be working on single-cell profiling for the iTARGETS blue-sky project.

September 15, 2020
Congratulation to Jiyang (co-I) and Dr. Junmin Peng for their newly funded R01 grant, entitled “Dissecting neuron-microglia-astrocyte interaction in AD pathogenesis.

September 1, 2020
Congratulations to Jiyang and Dr. Jun J. Yang for their newly funded R03! We will apply systems biology approaches to identify gene deregulations driving the pathogenesis of acute lymphoblastic leukemia in children with Down syndrome.

August 21, 2020
Congratulations to Hao Shi and Koon-Kiu Yan for the review paper on “Network Approaches for Dissecting the Immune System!“

July 30, 2020
Congratulations to Jingjing who contributed to Leukemia paper which studied crosstalk between GLI and FOXC1 transcription factors in T-ALL.

July 1, 2020
The iTARGETS Blue-skey Initiative is kicked off today! It aims to identify novel immunotherapy targets for pediatric cancers using systems immunology approaches. It is co-led by Dr. Hongbo Chi (Immunology) and Jiyang, in collaboration with Dr. Terry Geiger (pathology) and Dr. Stephen Gottschalk (Bone Marrow Transplantation & Cellular Therapy).

June 20, 2020
Welcome Xu Yang to join our group as a postdoc research associate!

April 16, 2020
Congratulations to Yuxin and Qingfei who contributed to a Cell paper in collaboration with Dr. J. Paul Taylor! We applied network biology approach to prioritize proteins in the stress granule interactome, highlighting G3BP1 as a tunable switch that triggers phase separation to assemble stress granules.

March 31, 2020
Congratulations to Jingjing and Jiyang who contribute to a paper recently accepted by Cancer Research in collaborator with Dr. Schuetz’s group. NetBID2 analysis identified a novel function of ABC transporter in medulloblastoma by regulating sonic hedgehog signaling.

March 9, 2020
Congratulations to Jingjing and Jiyang who contribute to a paper recently accepted by Nature Cancer in collaboration with Dr. Evan’s group. They integrated datasets from multiple platforms to identify genomic features associated with glucocorticoid resistance in B-ALL. CELSR2 was discovered by NetBID2 analysis.

December 11, 2019
Congratulations to Tracy and Jiyang who contributed to the new Nature paper on improving the therapeutic efficacy of REGNASE-1-deficient CD8+ T cells in collaboration with Dr. Hongbo Chi’s lab.

October 10, 2019
Congratulations to Isabel Risch for winning POE 2019 best paper award!

September 9, 2019
Our first R01 got funded!!! It's entitled "Intracellular and Intercellular Network Rewiring and Hidden Driver Inference from Single-Cell Data." We are looking for new postdocs to work on this existing area of single-cell systems biology! Please contact us if you are interested.

July 30, 2019
POE students Raghunandan Avula and Isabel Risch reported on their research projects at the Pediatric Oncology Education (POE) Lunch.

July 15, 2019
Welcome Hao Shi to join our group! Hao is a joint member between Dr. Hongbo Chi lab and Yu lab, and he will be working as a Systems Immunology Specialist.

June 1, 2019
Welcome Raghurandan Avula , Isabel Risch, Joao Veloso, Xinge Wang, Jonathan Zhang, Mingyue Zhang to join our lab as summer interns.

May 1, 2019
Welcome Xin Huang to join our lab as a postdoc fellow! Xin was the recipient of the Garwood Postdoctoral Fellowship through the St. Jude Comprehensive Cancer Center Developmental Biology and Solid Tumor Program. Xin will be working on pediatric solid tumors.

March 25, 2019
Congratulations to Tracy and Jiyang who contributed to the new Cell Research paper on novel functions of LKB1 in dendritic cells by our collaborator Dr. Hongbo Chi’s lab: https://www.nature.com/articles/s41422-019-0157-4.

March 6, 2019
Congratulations to Jiyang and Drs. Junmin Peng and Hongbo Chi for their review manuscript accepted at Current Opinion in Systems Biology. The review is titled “Systems immunology: Integrating multi-omics data to infer regulatory networks and hidden drivers of immunity”.

February 12, 2019
Jiyang presented “Hidden Drivers and Precision Medicine” at UTHSC Cancer Center!

Research highlighted in St.Jude Progress: Computational algorithm fix restores power to research.
Read more

January 28, 2019
Welcome Yuxin Li to co-join our group! Yuxin will be a joint member between Junmin Peng Lab and Yu Lab.

January 18, 2019
Jiyang presented together with Dr. Hongbo Chi at Cancer Biology Seminar January 18. Their talk is entitled “Systems immunology at the intersection of cancer and inflammation: applications and algorithms!

January 11, 2019
Congrtulations to Jingjing and Qingfei whose posters were selected to present at St. Jude Cancer Center’s Postdoctoral Symposium on Feburary 8!

December 17, 2018
Welcome Liang (Adam) Ding to the lab as a senior software engineer.

Noverber 16, 2018
Jiyang presented Qingfei’s work on single-cell studies of cancer metastasis in the 5th Annual Metastatic Breast Cancer Conference: https://www.mbcalliance.org/event/5th-annual-metastatic-breast-cancer-conference.

Noverber 13, 2018
Jiyang presented in Developmental Biology and Solid Tumor Program Seminar on November 13. His talk title is “Hidden Drivers and Precision Medicine”.

May 30, 2018
‘Hidden’ driver discovered with an interdisciplinary approach helps prime the anti-tumor immune response. Read more

Octorber 8, 2018
Welcome Xinran Sherry Dong to the Lab! Sherry is a visiting scientist from Fudan University Children’s Hospital.