About the Zhou Lab

Innovations in next generation sequencing and ‘big data’ acquisition have created a robust set of genomic data ripe for interrogation and analysis. The complexities and noisiness of this data present unique challenges to users at the bench or in the clinic. Our lab is interested in pioneering data visualization platforms that facilitate access to genomic information and support analysis by a broad audience of users. Ultimately, the tools we create bolster research efforts and reveal clues to understanding the etiology, progression, and treatment of catastrophic childhood diseases.

Science Team

Our research summary

Working in close collaboration with investigators and clinicians, our team creates interactive software solutions to facilitate access and support analysis of complex genomic information. Our innovations allow a user to call up a gene or locus of interest and field the information for that target with respect to all other annotations and details. We work primarily with the Departments of Oncology and Epidemiology & Cancer Control to build platforms using patient cohort and survivor cohort data. In addition to genetic information, our platforms embed data related to molecular signature, histopathology, clinical outcomes, and patient demographics.

  • ProteinPaint: A web service for simultaneously visualizing genetic lesions and RNA expression in pediatric cancers
  • GenomePaint: A web service to visualize somatic coding and noncoding alterations in pediatric cancers, along with multi-omics information to reveal noncoding alterations, enhancer hijacking, splicing aberrations, mutational signatures, and survival analysis
  • Survivorship Portal: Developed in collaboration with investigators from Epidemiology and Cancer Control, the portal shares high quality genomic, clinical and patient-reported data from survivors of pediatric cancer from SJLIFE and CCSS studies.

Our hybrid team of PhD scientists and web developers is uniquely suited to address and optimize the impactful questions of basic and clinical investigators. We conduct extensive architecture analysis and data interrogation to ensure our inputs and algorithms are accurate and robust. In addition to our current solutions, we are exploring new opportunities with collaborators in Neuro-Oncology and Hematology – creating resources to better understand, and treat, brain tumors and sickle cell disease.

We are looking to build our development team and are particularly interested in candidates with a background in the biological sciences and a passion for creating software to lower the data access barrier and promote cancer and biomedical research.

Selected Publications

About Xin Zhou

Dr. Xin Zhou is an accomplished leader in the design and development of state-of-the-art software solutions to advance biomedical research. He received his PhD from the China Agricultural University in Beijing and went on to train as a postdoctoral fellow in human genomics at Washington University in St. Louis. Dr. Zhou contributed to the Roadmap Epigenetics Consortium as an NIH/NIDA Fellow and has spearheaded the development of several transformative web-based platforms. He currently serves as the Director of Data Visualization at St. Jude. Dr. Zhou values the collaborative spirit of the institution, leading an interdisciplinary team with expertise in biology, genetics, and computational science.

Esther Obeng, MD

The team

Interdisciplinary team of scientists and developers bridging the communication gaps between experimental biology, bioinformatics, and clinical implementation

Contact us

Xin Zhou, PhD
Assistant Member, Computational Biology

Department of Computational Biology
MS 1135, Room IA6034
St. Jude Children Research Hospital

262 Danny Thomas Place
Memphis, TN, 38105-3678 USA
(901) 595-7070 xin.zhou@stjude.org
262 Danny Thomas Place
Memphis, TN, 38105-3678 USA
GET DIRECTIONS