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Computational tool helps to illuminate hidden mutations
07/06/2020
St. Jude researchers developed a powerful tool that can identify cancer-causing mutations in genomes.
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CHANGE-Seq tool helps target genome editing
06/15/2020
St. Jude scientists create more scalable tools to study genome-editing methods.
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Combination therapy holds promise for rare immune disorder
06/12/2020
Recent research shows how an overactive immune system produces too many cytokines in HLH.
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Predicting secondary cancer risk in childhood cancer survivors
06/04/2020
St. Jude scientists are studying the effect of cancer treatments and inherited mutations in DNA-repair genes.
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Caspase-8 triggers inflammatory signaling in multiple ways
05/18/2020
Beyond its role in cell death, St. Jude scientists have uncovered how caspase-8 contributes to inflammation.
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Scientists study how bacteria evolve to resist antibiotics
05/11/2020
Researchers at St. Jude contribute to a study of bacteria and its evolving resistance to antibiotics.
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Research reveals complexity of phase separation
05/06/2020
St. Jude researchers contribute to studying the nucleolus to learn more about phase separation.
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Fine tuning phase separation
04/16/2020
Studying the interactions between proteins and RNA which define phase separation, St. Jude researchers were able to determine how each protein contributes.
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Unraveling the mysteries of caspase-6
04/15/2020
St. Jude researchers discovered possible new ways to fight viruses and inflammatory illnesses.
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Expanding ways to tame a global childhood killer
04/07/2020
A new anti-malarial drug offers hope for children suffering from Malaria.
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Inherited mutation can drive SHH medulloblastoma
04/01/2020
Researchers find connections to inherited genetic mutations to a type of brain tumor. The study suggests certain genes should be included in routine testing.
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The role of oxygen in wiring the brain
03/16/2020
Scientists at St. Jude are studying the role oxygen plays in the maturation and migration of neurons and have identified a new mechanism that helps control these processes.
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Push to restore leukemia treatment effectiveness gains ground
03/09/2020
St. Jude Children’s Research Hospital scientists developed a way to discover the genes responsible for resistance to steroids in leukemia patients.
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Obesity linked to severity and longer duration of flu
03/03/2020
New research suggests that obesity may be linked to increased severity and longer duration of the flu as well as higher amounts of flu in the body.
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Predicting protein phase separation
02/06/2020
St. Jude has developed a way to predict how proteins phase separate. The answer will help scientists studying how these proteins contribute to disease.
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How MAGE-A11 gene drives cancer revealed
01/21/2020
Results show a gene that drives cancer by promoting alternative polyadenylation
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Chinese collaboration yields results
01/16/2020
St. Jude is working with the Chinese Children’s Cancer Group to lead the first Phase III clinical trial comparing targeted therapies for a high-risk type of leukemia.
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Models for Wilms tumor research
12/20/2019
Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor.
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Like a crystal ball, a blood test can predict when serious infections will strike
12/19/2019
Researchers at St. Jude showed that a new test predicted bloodstream infections up to three days before symptoms appeared.
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ALL risk genes give new understanding of leukemia biology
11/25/2019
Researchers find variant common in leukemia that afflicts children and a different leukemia that afflicts adults.
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Transporter activity depends on its cargo
11/13/2019
Scientists at St. Jude, Weill Cornell Medicine and Columbia University applied single-molecule imaging technologies to explain the activity of specific transporter proteins.
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Clinical trial lowers ALL relapse rate
10/28/2019
Results are in from a ten-year long clinical trial aimed at preventing relapse in pediatric patients with acute lymphoblastic leukemia.
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Understanding the control system for regulatory T cells
10/24/2019
MTORC1 may be more than just a molecular pathway. This enzyme may open up new avenues for treating autoimmune diseases and can boost cancer immunotherapy.
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Exercise may give the brain a boost
10/21/2019
A St. Jude study reveals more about the link between cancer survivors’ physical fitness and their thinking and learning skills.
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Pharmacogenetics of thiopurine and NUDT15 mutations presented at ASHG
10/18/2019
Researchers have uncovered a relationship between the gene NUDT15 and how thiopurine drugs function. These findings support the use of NUDT15 to guide thiopurine dose to limit treatment related toxicity.
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Study of telomere length and chronic health conditions presented at ASHG
10/16/2019
St. Jude researchers compared telomere length and age-dependent telomere attrition between childhood cancer survivors and adult control subjects.
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Do vitamins A and D help the flu vaccine work better? It depends.
10/08/2019
Vitamins A and D can impact how well some children respond to the flu vaccine.
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St. Jude will help lead national push to create more effective flu vaccines
09/30/2019
Flu is particularly dangerous for some people, including young cancer patients. Here’s the latest on how St. Jude scientists are working to protect them.
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Childhood cancer treatment can alter Leydig cell function
09/26/2019
Data from the St. Jude Lifetime Cohort Study reveals that current treatment for childhood cancer can affect testosterone production in men.
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Research reveals structural details of chaperones, critical molecules of the cell
09/20/2019
St. Jude scientists have uncovered a new discovery that reveals how chaperones manage protein folding – which could lead to finding ways to fight disease.
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Molecule offers focus for taming inflammation
09/12/2019
Chronic inflammation can be deadly. St. Jude researchers have identified a molecule that might lead to new ways to shut it down.
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How sweet it is: PeCanPIE serves up cancer variants
09/05/2019
Powerful cancer data portal gets an upgrade to identify the genetic culprit for inherited cancer and possibly other genetic diseases.
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Step aside Marie Kondo, the genome is the real organizational expert
09/04/2019
St. Jude researchers have uncovered the secrets of genome packaging revealed in the 3D genome.
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Monitoring infection in patients with compromised immune systems
09/03/2019
Digital polymarese chain reaction testing can correlate the amount of virus present in a sample with clinical systems.
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Taking a wider view reveals potential targets for rhabdoid tumors
08/27/2019
New study finds new rhabdoid tumor targets by identifying which targets these tumors need to survive.
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Reimagining β-thalassemia and its treatment
08/21/2019
Read the latest on a possible role for rapamycin treatment for b-thalassemia.
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Image captures ‘streamlined essence of what life entails’
08/19/2019
A St. Jude researcher may have found a possible answer to "one of the most interesting questions in science."
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Evaluating pediatric cancer through the lens of time
07/29/2019
New study accounts for years of life lost due to cancer. It’s the first time this metric has been used to analyze the childhood cancer burden globally.
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BRCA2 gene linked to risk of non-Hodgkin lymphoma
07/25/2019
A St. Jude study linked inherited mutations in the BRCA2 gene with a higher risk of non-Hodgkin lymphoma.
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Studying single cells to understand a type of pediatric brain tumor
07/24/2019
Scientists completed the most in-depth study of medulloblastoma subtypes by studying single cells to help shed light on how cells become cancerous.
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Learning from rare disorders
07/17/2019
Science Advances highlights St. Jude research into rare inherited Lysosomal disorders caused by mutations in the NEU1 gene.
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Too little or too much DUX4 is just right
07/11/2019
St. Jude researchers discover protein that may improve treatment for B-ALL in some patients. Learn more about how this gene’s expression impacts development.
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Scientists follow the data to a surprise
06/27/2019
Researchers surveyed the accumulation of toxic proteins in Alzheimer’s models, and discovered that a pathway nicknamed LANDO can limit the protein buildup.
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Leukemia mutations: sometimes less is more
06/26/2019
It’s true that adult tumors often have more mutations. Young ALL patients have fewer mutations, but the T cells identify more than two-thirds of them.
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Researchers discover key genetic trigger that compromises cancer immunotherapy
06/17/2019
T cell exhaustion has proven to be an obstacle for immunotherapy, and investigators hope their basic findings will result in techniques to prevent exhaustion.
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Study reveals function of cancer-linked MAGE genes
05/29/2019
The research shows that MAGE genes evolved to protect inherited DNA in men from stress, focusing on a subtype of MAGE genes called MAGE-A.
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Exploring how to get more out of vaccine protection
05/21/2019
Cell Host & Microbe study reveals the nearly 70 proteins the bacteria need to spread and set up shop (colonize) on someone new.
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Schedule changes improve treatment for acute lymphoblastic leukemia
05/20/2019
Scheduling delivery of the drug asparaginase with a discontinuous schedule of dexamethasone helps reduce bone damage when the two drugs were given together.
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Flu and strep team up to cause respiratory woes
05/20/2019
Researchers report for the first time that flu sticks to the surface of common respiratory bacteria.
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First St. Jude director and CEO honored as Giant of Cancer Care
05/10/2019
The Giants of Cancer Care recognition program honors those who advance the field of oncology through research or clinical care.
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Clues to help cancer survivors with hearing loss ace reading
05/02/2019
Research reveals that survivors with treatment-related severe hearing loss can benefit from personalized reading interventions to focus on reading skills.
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Researchers reveal key process that regulates cell division
04/30/2019
Read how fluctuations in the intrinsically disordered protein p27 play a key role in regulating cell division.
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Different immune cell implicated in lupus-related kidney disease
04/29/2019
This work shows for the first time that a type of immune cell called a patrolling monocyte plays a critical role in glomerulonephritis, inflammation of the kidneys
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Biological machinery of cell’s “executioner” yields secrets of its control
04/25/2019
Discovery of control signals for cell-killing necroptosis promises new treatment pathway for cancers and a broad array of other disorders.
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St. Jude gene therapy holds promise for treating several diseases, including SCID
04/17/2019
Out of the bubble: Newborns with SCID-X1, also known as "bubble boy" disease, have fully functional immune system for the first time after gene therapy. Learn more about the study.
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Mechanism revealed that dooms patients with Lou Gehrig’s disease
04/10/2019
Read about how the most common genetic cause of ALS disrupts cell function and how that might lead to new ways to diagnose and treat the disease
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Inherited gene variation may increase leukemia risk
04/01/2019
The scientists linked inherited variants of the gene USP7 with an increased risk of T-ALL. Changes in this gene are more common in individuals who are African American.
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Tracking the source of bone cancer mutations
04/01/2019
Read about efforts to improve cure rates for the bone cancer osteosarcoma by tracking how the chemo drug cisplatin may contribute to mutations.
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Genetic secrets yield treatment clues
03/29/2019
Genomic analysis reveals age-related subsets of acute erythroid leukemia.
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Finding a 'needle' in a 'haystack' just got easier
03/13/2019
Software helps to reduce error rates in next-generation sequencing data, expanding the clinical potential for the information.
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How one patient revealed a new route to melanoma
03/04/2019
Read latest on a mutation that drives the most common childhood melanoma plus evidence that patients who carry the alteration may respond to precision medicine.
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Radiation triples survival for a rare brain tumor
03/01/2019
Treatment success shown in ependymoma clinic trial open at more than 100 locations and with nearly 400 patients.
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Unraveling the connection between ancestry and cancer
02/21/2019
Scientists found variations in a fourth gene that is linked to a 50% increased ALL risk in Hispanic children. The risk was much lower for non-Hispanic children with the variation.
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Reducing alert fatigue
02/13/2019
A time-consuming issue for clinicians is assessing drug alerts in EHR systems. Researchers evaluated alerts and found ways to safely reduce alert overrides by 40 percent.
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Reprogramming immune cells to fight tumors from within
10/19/2018
Scientists have a new strategy to enhance the anti-cancer immune response and slow tumor growth. The goal is to reprogram macrophages to eliminate tumor cells.
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Rhabdomyosarcoma discoveries move from lab to clinic
08/23/2018
St. Jude scientists have completed the most complete analysis yet of the muscle and soft tissue tumor rhabdomyosarcoma.
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NCI awards ‘exceptional’ rating to St. Jude Comprehensive Cancer Center
08/22/2018
For the second time in a row, the National Cancer Institute (NCI) has awarded St. Jude the highest possible rank of “exceptional” during renewal of the hospital’s Comprehensive Cancer Center grant.
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Discovery may help some children avoid bone marrow transplantation
07/26/2018
Researchers have solved a decades-old mystery about which mutations cause a rare, inherited bone marrow disorder. The answer may allow some children to avoid bone marrow transplantation.
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St. Jude partners with University of Washington to improve knowledge worldwide
07/18/2018
St. Jude and the Institute for Health Metrics and Evaluation at the University of Washington are partnering to advance knowledge and understanding of childhood cancer around the world.
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Scientists identify a protein complex that shapes T cells’ destiny
07/06/2018
Like a mentor helping medical students choose between specialties, a protein complex helps shape the destiny of developing T cells, according to St. Jude scientists.
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Genetic counseling suggested for all childhood cancer survivors
06/19/2018
St. Jude has completed the first genome sequencing of cancer survivors and found that 12 percent of childhood cancer survivors may have a higher risk of cancer.
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Brain tumor subtype discovered that responds to less-aggressive treatment
05/17/2018
St. Jude researchers have discovered that a quarter of medulloblastoma patients have the infant SHH-II subtype. These patients may respond to less aggressive forms of chemotherapy, sparing them a lifetime of side-effects from treatment.
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WHO expands partnership with St. Jude
05/16/2018
St. Jude is the first WHO Collaborating Centre for Childhood Cancer. Read more about our exciting efforts to increase survival rates of children with pediatric cancer worldwide.
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A protein ‘gone rogue’ may lead to new cancer treatments
05/16/2018
A protein has been identified that may help researchers target and kill cancer cells more effectively. Learn more about this exciting discovery.
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Research pinpoints crucial flu mutation
04/24/2018
A mutation has been identified that may help scientists determine how to manufacture drugs to better fight the influenza virus. Learn more about the advances of treating drug resistant viruses.
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Fourth ALL predisposition gene discovered
04/19/2018
Scientists have discovered a new gene mutation that may help predetermine a child’s risk for developing ALL. Explore the latest breakthroughs.
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Injured cells and genetic variation may highlight a risk of neurocognitive problems
03/29/2018
St. Jude researchers recently discovered neurocognitive side-effects in patients may stem from leukemia itself, rather than solely from treatment-related causes. Read the latest.
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Molecule identified that serves as a sentinel for the immune system
03/22/2018
One specific molecule might be the key to preventing infections in pediatric patients. Learn more about this new discovery.
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How socially connected are cancer survivors? The answer might surprise you.
03/08/2018
As cancer survivorship increases, so do efforts to understand and strengthen social support and advice. Read the latest.
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A new avenue to prevent hearing loss
03/07/2018
The chemotherapy drug cisplatin may help save a child’s life. But that same medication can also damage a child’s hearing.
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At the deepest level, children are not just small adults when it comes to cancer
02/28/2018
A comprehensive analysis of the genes and mutations driving childhood cancer reveals just how different the disease is in children and adults.
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St. Jude Announces Plans for State-of-the-Art Advanced Research Center
02/19/2018
St. Jude announces plans for a new, state-of-the-art advanced research center that will reinforce the scientific efforts of our faculty members. Learn more about this new addition to the St. Jude community.
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Bringing hope and effective treatment to young refugees with cancer
02/18/2018
The Lebanese refugee crisis offers lessons in how to provide effective treatment for cancer and chronic diseases during emergencies.
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The chance to earn modest rewards may help get kids moving
02/12/2018
Want young cancer survivors to stay active? Pilot study finds the chance to earn stickers, T-shirts and other rewards helps keep survivors moving.
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DNA in 3-D reveals a ‘hijacking’ that drives neuroblastoma
01/23/2018
The oncogene c-MYC drives high-risk neuroblastoma in some young cancer patients. The findings lay the groundwork for much needed precision medicines.
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Improving vaccination rates in hospitals
01/10/2018
A St. Jude quality improvement initiative that greatly increased the employee vaccination rate for pertussis, or whooping cough, offers a model for other health care institutions nationwide.
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A double whammy for leukemia patients
01/04/2018
St. Jude scientists have discovered new germline variations in a tumor suppressor gene called TP53. Children with these variants are at risk of developing leukemia.
