Tumors can harness healthy white blood cells to enhance their own growth and suppress attacks by the immune system.
St. Jude researchers have discovered that the immune suppression is primarily the work of cells called monocytes.
St. Jude-led study, researchers found new genetic changes that drive the development of a high-risk leukemia subtype known as Ph-like ALL, and showed that patients may benefit from treatment with drugs called tyrosine kinase inhibitors.
Just as accessories like boots and gloves help humans adapt to their environment,
St. Jude Children’s Research Hospital scientists have discovered a mechanism that serves as an “on” switch for the machinery that helps proteins accessorize.
St. Jude scientists have just determined that after birth, the enzyme RIPK1 functions like an umpire in cells, making the tough calls necessary to balance competing signals that determine if cells live or die.
DNA may be the cornerstone of life, but the molecule breaks all the time. To read DNA’s code or make more DNA, cells routinely nick and unwind the famous double helix using specialized enzymes. Free radicals and other stresses can also break DNA.
We depend on the disease-fighting immune system to protect us from flu infections or to help us recover if we catch the virus. Now there is evidence the immune system can also help to predict which flu patients will develop severe symptoms and wind up in the hospital.