Cryo-Electron Microscopy and Tomography Center

The St. Jude Department of Structural Biology is constructing a world-class Center for Cryo-Electron Microscopy (Cryo-EM) slated to open in spring 2018. This facility will allow St. Jude researchers to visualize intricate biological structures, such as large macromolecular complexes, with atomic resolution. The Cryo-EM Center will also allow visualization of nanometer-scale 3D biological structures in their native cellular context.

The first instruments to be installed in the center will include a Titan Krios electron microscope and a Talos Arctica transmission electron microscope. These instruments incorporate several recent advances in technology that permit a very fine level of image detail to be observed. These improvements provide image quality that was not previously possible. A shared resource open to all St. Jude investigators, the St. Jude Cryo-EM Center will enable molecular-level examination of the differences between healthy and diseased cells with unprecedented detail and clarity.