Description
Researchers at St. Jude developed an anti-CD7 chimeric antigen receptor (CD7 CAR) to use for treating hematologic cancers expressing the CD7 gene, which include lymphoblastic T-cell leukemia and lymphomas. The majority of T-cells, approximately 90%, express CD7 and are removed before transduction. The CD7 CAR is introduced into the remaining subset of T cells that do not naturally express CD7.
Keywords
chimeric antigen receptor, gene therapy vector, anti-CD7-CAR, T-cell malignancies
Granted Patents or Published Applications
International application published as WO 2017 213979 A1, US Pending
Related Scientific References
Licensing Opportunities
Please contact us if you are interested in licensing this technology. Contact: chad.riggs@stjude.org.
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Technologies
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- Development and Optimization of a Serotype-Independent Method of Adeno-Associated Virus (AAV) Harvest and Purification (SJ-16-0036)
- DNA Methylation Profile and Biomarkers for identifying functional T-cells (SJ-17-0002)
- DNMT3a knockout CAR T cells with Antigen Specificity (for solid tumors) (SJ-19-0024)
- Efficient generation of T-Cell Receptor (TCR) sequences in response to a variety of immune responses (SJ-19-0017)
- Erythroid Specific Promoter for Hematopoietic Disorders (SJ-16-0040)
- HMGA2 in Gene Therapy Vectors (SJ-16-0014)
- Hybrid Compounds to treat Gastrointestinal Infections (SJ-14-0019/UTA 14-01)
- Immune Cells with DNMT3A Gene Modifications (SJ-16-0009)
- Improved Method to Produce Proteins to Treat Lysosomal Storage Disorders (SJ-01-0020)
- iNKT Cell Expansion Protocol (SJ-12-0033)
- Method for Enhancing Recombinant Antibody Production (SJ-08-0032)
- Method for predicting T-cell development stage (and therapy success) (SJ-19-0033)
- Minimized Liver Specific Promoter for Improved Gene Expression in Gene Therapy Vectors (SJ-04-0024)
- New Method for Differentiating T-cells (SJ-18-0019)
- p53 Inhibitory Oligonucloeotides (SJ-09-0015)
- Rapid Cloning of T Cell Receptors (SJ-16-0001)
- Regulating p53 Translation and Function (SJ-05-0002)
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- Safety Test for Gene Therapy Vectors (SJ-15-0027)
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.