During the first 2 to 4 years of life, humans learn much more efficiently than they do during adulthood. This ability to learn depends on plastic changes in the cortices of the brain. In adults, this plasticity is lost and the ability to learn is diminished. Researchers at St. Jude discovered that inhibiting adenosine production or signaling in the auditory thalamus, which processes auditory information, can convert adult-like plasticity to juvenile-like plasticity. Thus, by inhibiting the expression or function of Nt5e or A1R, learning abilities in adults can be rejuvenated.
This invention provides a method for improving learning and memory and treating neurological disease associated with auditory, visual, somatosensory or motor abnormalities. The invention involves administration of an inhibitor of ecto-5’-nucleotidase (Nt5e, aka CD73) or A1 adenosine receptor (A1R, aka Adora1). Various molecules and compounds capable of inhibiting these two genes are disclosed.
Cortical plasticity, adenosine regulation, improved learning, neurological disease
Granted Patents or Published Applications
PCT/US16/18377 is the published PCT application claiming this invention.
Related Scientific References
J.A. Blundon el al., "Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling," Science (2017). science.sciencemag.org/cgi/doi … 1126/science.aaf4612
Read more details and description of the Science publication at: https://medicalxpress.com/news/2017-06-brain-chemical-window-language-music.html#jCp
Thalamocortical long-term potentiation becomes gated after the early critical period in the auditory cortex; J Neurosci. 2013 Apr 24;33(17):7345-57. doi: 10.1523/JNEUROSCI.4500-12.2013.
Presynaptic gating of postsynaptic synaptic plasticity: a plasticity filter in the adult auditory cortex; Neuroscientist. 2013 Oct;19(5):465-78. doi: 10.1177/1073858413482983. Epub 2013 Apr 4.
Presynaptic gating of postsynaptically expressed plasticity at mature thalamocortical synapses; J Neurosci. 2011 Nov 2;31(44):16012-25. doi: 10.1523/JNEUROSCI.3281-11.2011.
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